Mojtaba Moosavian's research while affiliated with Ahvaz Jundishapur University of Medical Sciences and other places

Publications (40)

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This study investigated the prevalence of Clostridioides difficile by culture, multiplex polymerase chain reaction (M-PCR), and loop mediated isothermal amplification (LAMP) in patients with suspected C. difficile infections (CDIs). Also, the results of three methods were compared. All stool specimens collected from CDI suspected patients were cult...
Preprint
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The oral cavity can act as an extra gastric reservoir for H pylori, and also the presence of the bacteria in the oral cavity is associated with a higher risk of dental caries development. The aim of this study was to determine the genotype and evaluate the association of the presence of H. pylori in dental plaque and gastric biopsy specimens in dys...
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Antibiotic resistance mechanisms in Enterobacteriaceae are causative agents of global health problems. Bacterial infections due to multidrug resistance (MDR) may be mediated by the overexpression of efflux pumps. In this study, we investigated the prevalence of oqxA and oqxB genes as two encoding agents of efflux pumps and the determination of anti...
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Background This study aimed to investigate the occurrence of Legionella species in the respiratory samples of patients with pneumonia symptoms from Ahvaz, Iran by culture and the real-time PCR of 23S-5S rRNA gene spacer region.Methods and resultsA total of 123 clinical respiratory samples including 63 pleural aspirates, 57 bronchoalveolar lavage (B...
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Background: Early-onset neonatal sepsis (ENOS) is one of the most common causes of mortality in neonates. The bacteria causing ENOS are generally transferred from the mother to the infant before or during labor. Objectives: This study aimed to determine the prevalence rate of nasopharyngeal colonization with common bacterial agents causing ENOS and...
Preprint
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Background Early-onset sepsis is one of the most common causes of mortality in neonates. This studyaimed to determine the prevalence rate of nasopharyngeal colonization with commonbacterial agents causing early-onset neonatal sepsis and their relationship with blood cultureoutcomes in neonates.Method All neonates transferred to the neonatal intensi...
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Acinetobacter baumannii is one of the most important organisms in nosocomial infections. Antibiotic resistance in this bacterium causes many problems in treating patients. This study aimed to investigate antibiotic resistance patterns and resistance-related, genes in clinical isolates of Acinetobacter baumannii. This descriptive study was conducted...
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The emergence of multidrug-resistant Escherichia coli has become a great challenge in treating nosocomial infections. The polymyxin antibiotic colistin is used as a ‘last-line’ therapy for such strains, but resistance to colistin is increasingly emerging all over the world. In this study, we investigated lipopolysaccharides (LPS) of colistin-resist...
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Introduction The cinnamon is one of the most popular and the oldest spices used as a traditional herbal medicine. The aim of this study was to determine the antibacterial properties of Cinnamomum zeylanicum bark essential oil (EO) against some extensively drug-resistant (XDR) clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA),...
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Background: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most pathogens associated with health care. Molecular typing methods are vital for outbreak investigations of MRSA. The aim of this study was characterization of SCCmec, spa types and multidrug resistant of methicillin-resistant Staphylococcus aureus isolates in Ahvaz, Ir...
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Legionellosis is the generic term used to describe infections caused by different varieties of Legionella spp., including Legionnaires’ disease (LD), a severe and potentially fatal form of pneumonia, and Pontiac fever, a self-limited flu-like illness. Legionellosis is usually acquired through inhalation or aspiration of aerosols containing Legionel...
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Legionella species are widespread in natural water sources and man-made aqueous environments, as well as fresh-water. The present study was conducted owing to the lack of research regarding the prevalence of Legionella spp in the water sources of Ahvaz city in southwest Iran. In this study the macrophage infectivity potentiator (mip) gene sequencin...
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Background:SPATE (serine protease autotransporters of enterobacteriaceae) genes are considered as a group of the main virulence factors of Shigella species This study aimed to investigate for the first time the distribution of SPATE genes among Shigella spp. isolated from children with diarrhea infection in Ahvaz, Iran. Methodology: In this study,...
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Background: The emergence of the plasmid-mediated mcr colistin-resistance gene in bacteria poses a potential threat for treatment of patients, especially when hospitalized. The aims of this study were to search for the presence of mcr-1 and mcr-2 genes among colistin-resistant Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) iso...
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Background: Legionnaires’ disease is an important public health problem that can cause substantial mortality and morbidity. Legionnaires’ disease-risk estimation may be compromised by uncertainties in Legionella-detection methods. The aim of this study was the detection of L. pneumophila in respiratory specimens of hospitalized patients with respir...
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Introduction: Shigellosis is a significant global human health problem, and Shigella is in charge of almost 165 million cases of this disease annually, of whom 163 million cases are in developing countries and 1.5 million cases are in developed countries. The main aims of the current survey were to identify Shigella spp. isolated from diarrheal pat...
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Background: Chlamydia trachomatis, Ureaplasma urealyticum, and Mycoplasma hominis are common sexually transmitted microorganisms. Objectives: The aim of the study was to determine the prevalence of these microorganisms in infertile couples and the effect of these infections on semen parameters. Methods: In this case-control study, samples were coll...
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Objective: Nosocomial infections due to vancomycin-resistant enterococci (VRE) are known as a source of spreading these bacteria. The aim of this prospective study was molecular detection of vanA and vanB genes among VRE isolated from patients admitted to intensive care units (ICUs) in Ahvaz in southwest of Iran. Materials and methods: Overall, 243...
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Introduction: Diffusion of antibiotic resistance genes by horizontal gene transfer has led to the fast emergence of multidrug resistance (MDR) among bacteria. Multiple classes of integrons are effective genetic elements which play a significant role in the acquisition and nosocomial dissemination of resistance factors in strains of Gram-negative ba...
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Shigella spp. are a major cause of bacillary dysentery, particularly among children in developing countries such as Iran. This study aimed to investigate the presence of two important Shigella enterotoxins (ShET-1 and ShET-2), encoded by the set and sen genes, respectively, by polymerase chain reaction (PCR) assay among Shigella species isolated fr...
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NDM-1 producing bacteria are highly resistant to beta-lactams, including carbapenems. So the emergence of these microorganisms becomes a problem for the health system. The aim of this study was to investigate the presence of NDM-1 by PCR in clinical isolates of Carbapenem-resistant Enterobacteriaceae (CRE) in the university-associated hospitals i...
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Background: Acinetobacter baumannii has appeared as an important opportunistic pathogen responsible for nosocomial infections. The rising trend of antibiotic resistance amongst A. baumannii isolates has become a global concern. The most prevalent procedure of resistance is beta-lactamase and carbapenemases production with genes on mobile elements....
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Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen. We sought to determine the frequency of the different types of SCCmec in MRSA isolates by performing a cross-sectional study. A total of 72 S. aureus isolates were collected from Imam Khomeini and Golestan hospitals and analysed for MRSA and SCCmec typing by multiple...
Article
Background: Legionnaires’ disease (LD) is a common form of severe pneumonia, caused by Legionella spp. Legionella pneumophila is an important agent of severe pneumonia including 15 serogroups, which are all human pathogens. However, L. pneumophila serogroup 1 is the most prevalent agent of LD. Fatality rates among elderly and immunocompromised pati...
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Background: Carbapenem-resistant Acinetobacter baumannii has emerged as an important cause of infection in burn patients. This study aimed to characterize the antimicrobial susceptibility pattern, determine the prevalence of oxacillinase and metallo-beta-lactamase (MBL) genes, and type the A. baumannii isolates obtained from burn patients. Method...
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Background: A common mechanism of resistance to beta-lactam antibiotics is the production of beta-lactamase by Gram-negative bacteria. Recently, nonderivative extended-spectrum beta-lactamases (ESBLs) from the TEM and SHV enzymes, such as CTX-M, that were related to different geographical regions have been recognized. Objectives: The aim of this...
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Background: In recent decades, multidrug-resistant non-fermenting Gram-negative pathogens, particularly Acinetobacter baumannii and Pseudomonas aeruginosa, have been recognized as a major cause of healthcare-associated and nosocomial infections and outbreaks. Objectives: The aim of this study was to determine the prevalence and pattern of antibi...
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Background: Carbapenem resistant Acinetobacter baumannii is an important nosocomial pathogen associated with a variety of infections. Objectives: The current study aimed to characterize the antimicrobial susceptibility, analyze the prevalence of oxacillinase and metallo-β-lactamase (MBL) genes and molecular typing of clinical isolates of A. baum...
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Background and objectives: Carbapenem resistant Pseudomonas aeruginosa is a serious cause of nosocomial infections. The main purpose of the study is to determine the prevalence rate of imipenem resistant Pseudomonas aeruginosa carrying metallo-ß-lactamase (MBL) genes. Material and methods: 236 Pseudomonas aeruginosa isolates were collected from...
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Background and Objectives: Carbapenem resistant Pseudomonas aeruginosa is a serious cause of nosocomial infections. The main purpose of the study is to determine the prevalence rate of imipenem resistant Pseudomonas aeruginosa carrying metallo- beta- lactamase (MBL) genes. Material and Methods: 236 Pseudomonas aeruginosa isolates were collected fro...
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Introduction: One of the most important agents in hospital-acquired infections is Staphylococcus aureus. Treatment of methicillin-resistant S. aureus (MRSA) infections with decreased susceptibility to vancomycin has recently been more difficult. The aim of this study was to evaluate the possible presence of vancomycin intermediate S. aureus (VISA)...
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Resistance to macrolide can be mediated by erm and msrA genes in Staphylococcus aureus. There are the evidences that show erm genes may be causative agent of inducible or constitutive resistance. The aim of this study was to investigate the incidence of inducible clindamycin resistance and determine the most frequency of erm and msrA genes among S....
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Recently Acinetobacter baumannii isolates have emerged as a problematic infectious agent that causes meningitis in neurosurgical patients. Colistin has been used successfully for the treatment of A. baumannii meningitis but colistin resistant isolates have been reported worldwide. Two isolates of A. baumannii were cultured during a five-day period...
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Carbapenem resistant A. baumannii is an emerging cause of nosocomial infections. The aims of this study were identification of the most prevalent of carbapenem resistant genes, molecular typing and antimicrobial evaluation of A.baumannii in intensive care units. Two hundred and six A. baumannii were isolated from tracheal tube discharge of hospital...
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The emergence of heterogeneous populations of methicillin-resistant Staphylococcus aureus (MRSA) causes major problems in routine screening for MRSA. Cefoxitin is a potent inducer of the mecA regulatory system and can be use for detection of heterogeneous populations of MRSA. Detection of the mecA gene by PCR was considered to be the "gold standard...
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Background: Although infection with Helicobacter pylori is a global health problem, its prevalence is different among countries. Serologic tests for the diagnosis of H. pylori infection are limited by low accuracy rates and lack of validation. Recent studies indicate that the stool antigen test has an acceptable level of accuracy. Objectives: Our...
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Background and Objective: Pseudomonas aeruginosa is a causative agent of nosocomial infections. Metallo-beta-lactamases (MBLs) are considered among the most crucial resistant agents of Pseudomonas aeruginosa to carbapenem. Because of the important role of carbapenemes in the treatment of Pseudomonas infections, in this study, the Pseudomonas aerugi...

Citations

... The diameter of the bacteriostatic rings was observed and measured after culturing at 37 • C for 24 h. According to the standards of the Clinical and Laboratory Standards Institute (CLSI), the drug sensitivity of the isolated strain was evaluated [22,23]. ...
... According to the studies, the proper antibiotic selection is challenging because these bacteria are resistant to different antibiotics by using various antibiotic resistance mechanisms. All Gramnegative bacteria herein were colistin-sensitive, similar to studies by Moosavian et al. [59] and Sharifi et al. [60]. It can be used as a treatment against MDR Gram-negative isolates. ...
... Yang et al. (2019) investigated the mode of action of bark essential oil at their sub-inhibitory concentration (0.08% v/v) against KPC-KP cells (Klebsiella pneumoniae carrying carbapenemase gene) from a proteomic perspective and found that KPC-KP cells exposed to essential oil undergo oxidative stress. Promising antimicrobial activity of the bark extract, bark essential oil and bioactive compound cinnamaldehyde have been also studied by several researchers (Vinitha and Ballal, 2008;Khan and Ahmed, 2013;Choi et al., 2016b;Mota et al., 2019;Bouhdid et al., 2010;Unlu et al., 2010;Al-Mariri et al., 2012;Evrendilek, 2015;Saleem et al., 2015;Utchariyakiat et al., 2016;Elgendy et al., 2016;Essid et al., 2017;Ainane et al., 2019;Saki et al., 2020). ...
... Presence of LPS is characteristic to gram-negative bacteria, and its complete loss is rare. In some bacteria, loss of LPS was suggested to be partially compensated for by the production of other classes of lipids in the outer membrane [98]. Liberibacter spp. ...
... Migration of a large group of Afghan and Iraqi population to Iran, due to political unrests in these countries over the previous decades as well as illegal drug and human trafficking through the eastern borders with Pakistan and Afghanistan, has prejudiced the health system of the country [8]. Drug resistance in Iran is expected to be the most significant challenge as there is no local report or monitoring system for such resistance [9][10][11][12]. The present study was conducted to investigate the aerobic and anaerobic bacterial profile of nosocomial infections and to evaluate their antibiotic resistance in southwest Iran. ...
... Legionella spp. are gram-negative intracellular pathogenic bacteria, are ubiquitous in water and soil, and are represented by more than 66 species, some of which are potentially capable to cause a severe form of pneumonia, called Legionnaires' disease (Jomehzadeh et al., 2019;Parte et al., 2020). Legionella pneumophila (Lp) is the most common infectious agent involved in Legionnaires' disease and consists of 15 different serogroups. ...
... Also, 60.8% of positive samples from water resources belonged to serogroup 1 in our study. Based on other reports from different regions of Iran, serogroup 1 is more frequently found in water resources (Moosavian et al. 2019;Yaslianifard et al. 2019), although it varies in other countries (Den Boer et al. 2008;Harrison et al. 2007). The distribution of legionella isolates may depend on the location and geographical area, as shown in a study from Korea (Lee et al. 2010). ...
... It is known that three classes (class I, class II and class III integrons) frequently obtained from clinical sources (Gillings, 2014). Based on previous study, class 1 integrons, as the most widespread element, is linked with multidrug-resistant organisms (MDROs) and they had resistance to several types of antimicrobials (Moosavian et al., 2018;Eghbalimoghadam et al., 2017). So, the aim of this study was to evaluate the antibiotic resistance and determine the frequency of encoding genes of blaIMP, blaVIM and class I integron in clinical strains of A. baumanii obtained from burn patients in Sari, North of Iran. ...
... Several previous studies in Iran and other countries also reported genetic diversity among K. pneumoniae isolates. For instance, a study on CST-resistant K. pneumoniae isolates in the southwest of Iran reported 23 ERIC types among 26 isolates [46]. Another study reported 32 ERIC types among 35 K. pneumoniae isolates. ...
... Antibiotics, such as trimethoprim-sulfamethoxazole and ampicillin, were formerly prescribed for shigellosis; however, their restriction for administration was suggested by WHO due to widespread resistance [10]. In our study, all our S. flexneri strains were resistant to ampicillin and trimethoprim/sulfamethoxazole; however, low frequency of resistance to azithromycin and ciprofloxacin was detected that was comparable to previous reports [13,27,28]. This finding is consistent to recent recommendations for prescribing fluoroquinolones and azithromycin, as drug of choice for shigellosis in children [11,29]. ...