Mohammad Moradzad's research while affiliated with Kurdistan University of Medical Sciences and other places

Publications (4)

Article
Full-text available
Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. Macrophages orchestrate the process of wound...
Article
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Background Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disorder with complicated pathophysiology. Trimethylamine-N-oxide (TMAO) has been thought to be correlated with the pathogenesis of NAFLD. The single nucleotide polymorphisms (SNPs) of hepatic flavin-containing monooxygenase 3 (FMO3) regulate the concentration of TMAO. This ca...
Article
Full-text available
By the emergence of SARS CoV-2 variants, many studies were developed to deal with it. The high transmissibility and mortality rate of some variants, in particular developing countries have caused the operation of simple diagnostic tests for genomic surveillance. In this study, we developed two assays of High Resolution Melting (HRM) and Probe-based...
Article
Objective Membrane type-matrix metalloproteinases (MT-MMPs) are known as key regulators of cancer progression/metastasis. However, their roles in the growth and progression of multiple myeloma (MM) have not been yet elucidated. Methods and materials The expression of 6 MT-MMPs in MM, B cell lines, and normal peripheral blood (PB) cells were measur...

Citations

... In the present study, infiltration of these cells was associated with high-risk scores with poor prognosis, confirming the contribution of these cells in the breast cancer progression (Chen et al. 2017;Farmaki et al. 2020;Mouchemore et al. 2018). The polarization of macrophages to the M1 or M2 phenotype often results in different cytokine secretion and function (Hassanshahi et al. 2022;Lee 2019). M1 macrophages usually produce IL-12 and tumor necrosis factor with anti-tumor effects, while M2 macrophages often produce inhibitory cytokines such as IL-10, which have the opposite effects (Jeong et al. 2019). ...
... One study used nuclear magnetic resonance spectroscopy, whereas another used early gas chromatography-mass spectrometry. Information regarding study characteristics was not available for the study of Moradzad et al. [21]. Only one study reported the odds ratio (OR) of TMAO levels with the presence of NAFLD [20]. ...
... In this study, the two-step nested PCR improved the detection limit of the HRM assay, and low-copy virus samples could be identified, such as those having Ct values of 35. Moradzad et al. (26) reported that a one-step HRM assay can detect SARS-CoV-2 mutations with relatively high sensitivity and specificity, similar to the TaqMan probe assay. However, they used high-copy number viral RNAs (10 ng RNA in a tube) for HRM analysis. ...
... Compared to other cohorts [19,31,[33][34][35][36][37], our patients were younger (median of 55 years vs. 65 years), presented more commonly with osteolytic lesions (90% vs 35%) and had more frequently higher levels of LDH (35% vs. 12%). In line with other series [33], combined abnormal cytogenetics analyses were detected in 61.3% of our patients and 22.6% had hyperdiploidy. ...