Mohammad Farhan Ali's research while affiliated with Jamia Millia Islamia and other places

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Publications (3)

Contrasting conformational dynamics of β-sheet A and helix F with implications in neuroserpin inhibition and aggregation
Article
  • Jan 2021
Neuroserpin (NS) is an inhibitory protein of serpin super family, its shutter region variants have high propensity to aggregate leading to pathological disorders like familial encephalopathy with NS inclusion bodies (FENIB). Helix F and β-sheet A of NS participate in the tissue plasminogen activator (tPA) inhibition but the mechanism is not yet com...
Changes in strand 6B and helix B during neuroserpin inhibition: Implication in severity of clinical phenotype
Article
  • Jan 2020
Neuroserpin (NS) is predominantly expressed in brain and inhibits tissue-type plasminogen activator (tPA) with implications in brain development and memory. Nature of conformational change in pathological variants in strand 6B and helix B of NS that cause a relatively mild to severe epilepsy (and/or dementia) remains largely elusive. MD simulation...
Role of heparin and non heparin binding serpins in coagulation and angiogenesis: A complex interplay
Article
  • Jun 2016
Pro-coagulant, anti-coagulant and fibrinolytic pathways are responsible for maintaining haemostatic balance under physiological conditions. Any deviation from these pathways would result in hypercoagulability leading to life threatening diseases like myocardial infarction, stroke, portal vein thrombosis, deep vein thrombosis (DVT) and pulmonary emb...

Citations

... Undigested non-methylated daughter plasmid DNA was used for transformation in DH5α strains of E. coli for plasmid amplification [44]. ...
Reference: Strand 1A variant in neuroserpin shows increased aggregation and no loss of inhibition: Implication in ameliorating polymerization to retain activity
... Helix F has been predicted to unfold at both N and C terminal end during RCL transition, but another hypothesis predicted helix F to be displaced and rearranged after RCL transition [12,[31][32]. Variants in the helix F, strand 6B, helix B and strand 2A in the shutter regions show appreciable increase in the polymerization, however in these variants inhibitory activity against tPA is largely maintained [13,44,45]. Strand 1A is away from the RCL insertion site however it is connected to the helix F through a loop and its N-terminal end connects to s2A ...
Reference: Strand 1A variant in neuroserpin shows increased aggregation and no loss of inhibition: Implication in ameliorating polymerization to retain activity
... Heparin is a well-known regulator of the coagulation cascade that is also a potent inhibitor of angiogenesis [708] (see Figure 12). Heparin, therefore, directly modulates the coagulation cascade and is an excellent anticoagulant in diseases where hypercoagulation is prevalent. ...
Reference: The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications