Mohammad Alim’s research while affiliated with Invertis University and other places

Metformin HCl (MH), is an oral anti-diabetic drug with less bioavailability, and a BCS class III, short plasma half-life as well as narrow absorption window. The objective of this research work is to obtain better delivery of MH to the upper part of GIT by increasing the mean residence time (MRT) in the stomach. For this, Gastroretentive swellable and floating sustained release tablets were prepared to prolong the gastric emptying that provides maximum drug at the site of absorption. Different formulations were prepared by wet granulation with the help of hydrophilic polymers like different grades of hyroxypropyl methyl cellulose (HPMC), xanthan gum (XG), sodium alginate (SA), carbopol 940; hydrophobic polymer like ethyl cellulose (EC); swelling agent like crospovidone (CP) and gas generating agent sodium bicarbonate (SBC). The formulations were evaluated for pre and post-compression characteristics; the formulation F5 gave the optimum result along with >24 hrs floating time and an in vitro release profile very near to desire release. Release kinetic studies showed that all batches followed Super case II transport mechanism and first order kinetics. The optimized formulation F5 also subjected to 40°C and 75% relative humidity for stability test and remained stable during the period of 3 months.

Over the past 30 years, as the expense and complications involved in marketing new drug entities have increased, with concomitant recognition of the therapeutic advantages of controlled drug delivery, greater attention has been focused on development of sustained or controlled release drug delivery systems (DDS). For many disease states, a substantial number of therapeutically effective compounds already exist. The effectiveness of these drugs is often limited by side effects or necessity to administer the compound in an ethical setting. The goal in designing sustained drug delivery is to reduce the frequency of dosing or to increase the effectiveness of the drug by localization at the site of action, reducing the dose required or providing uniform drug delivery. The design of oral sustained release DDS depends on various factors such as, physicochemical properties of drug, type of delivery system, disease being treated, and patient condition, and treatment duration, presence of food, gastrointestinal motility, and co-administration of other drugs. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All Rights Reserved.

The aim of this research paper was to develop a simple, sensitive, rapid, accurate and economical Ultra Violet spectrophotometric method for the estimation of Domperidone.The study was performed in pH 6.8 phosphate buffer with 0.5 % Sodium Lauryl Sulphate (SLS) and presence of the drug was analysed using UV spectrophotometer. Various analytical parameters such as linearity, range, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ) were determined according International Conference on Harmonization (ICH) guidelines. Absorbance maximum (λmax) of drug in pH 6.8 phosphate buffer was found to be 284 nm. Beer's law was obeyed over the concentration range of 2-10 µg/ml with a correlation coefficient (R 2) value of 0.999. % RSD values below 2 at different concentration levels for Intra and inter-day precision indicated that the proposed spectrophotometric method is highly reproducible. LOD and LOQ were 0.84 and 2.54µg/ml respectively signifying that it can be adopted for routine quality testing. The results of the study demonstrated that the developed method is accurate, precise and reproducible while being simple, cheap and less time consuming and hence can be suitably applied for the analysis of Domperidone in pharmaceutical preparations for dissolution studies.