Miriam Palacios's research while affiliated with Pontificia Universidad Católica de Chile and other places

Publications (4)

Article
Full-text available
Xenopus laevis are able to regenerate the spinal cord during larvae stages through the activation of neural stem progenitor cells (NSPCs). Here we use high-resolution expression profiling to characterize the early transcriptome changes induced after spinal cord injury, aiming to identify the signals that trigger NSPC proliferation. The analysis del...
Article
Xenopus has been widely used as a model organism to study wound healing and regeneration. During early development and at tadpole stages, Xenopus is a quick healer and is able to regenerate multiple complex organs-abilities that decrease with the progression of metamorphosis. This unique capacity leads us to question which mechanisms allow and dire...
Article
Full-text available
Xenopus laevis frogs are a widely used organism to study aspects of modern biology (Harland and Grainger, 2011). Its central nervous system is particularly interesting, because in certain stages of metamorphosis the spinal cord can regenerate after injury and recover swimming. With this in mind, automatic gait analysis could help evaluate the regen...
Article
Spinal cord injury (SCI) is a tremendously devastating disorder with no effective therapy. Neuroprotective strategies have been applied aiming to prevent secondary cell death but no successful and robust effects have been observed. Recently, combinatorial approaches using biomaterials with cells and/or growth factors have demonstrated promising the...

Citations

... However, the antioxidant effects of single polymer biomaterials are relatively limited. To compensate for this, various therapies combining drugs with biomolecular materials have emerged, including minocycline, glutathione, vitamins, and melatonin wrapped in scaffolds to protect against oxidative stress (Courtine and Sofroniew, 2019;Morgado et al., 2019;Zimmermann et al., 2021). Based on the polysialic acid (PSA) sustained-release delivery system, minocycline can be loaded and administered continuously for up to 75 h. ...