Mingming Liang's research while affiliated with Anhui Medical University and other places

... It is associated with a higher risk of coronary artery disease, myocardial infarction, stroke, falls, fracture, road accidents and death. [5][6][7][8] A sustained reduction in systolic BP on standing is an independent risk factor for death with a 45% 5-year mortality. 9 Furthermore, the diagnosis can be overlooked when patients with delayed OH are unaware of their reduced cerebral perfusion, reporting falls rather than dizziness or syncope. ...

... The results showed that in hypertensives without diabetes, intensive BP lowering resulted in lower rates of new LVH in those without LVH at baseline, and higher rates of LVH regression in those with existing LVH. In a meta-analysis of 9 RCT, Zhang et al. [34] explored the question further, assessing the effect of intensive BP lowering in incident heart failure. The pooled analysis of nine prospective, randomized controlled trials indicated that intensive SBP decrease the risk of HF in patients without diabetes and in those aged ≥65 years. ...

... Second, since an increased prevalence of obstructive sleep apnea has been observed in women with PCOS(42), xanthine oxidase, an enzyme that plays a key role in uric acid synthesis, could be activated under hypoxic conditions in those patients (43). Third, increasing evidence has shown that more than 60% of free fatty acids (FFAs) are released from upper-body subcutaneous adipose tissue (44). ...

... (11) Later, a multicenter randomized clinical trial with 284 patients with Covid-19 demonstrated that the addition of Lianhua Qingwen Capsule to usual treatment led to a higher symptom recovery rate (fever, coughing and fatigue), a higher chest computed tomography (CT) manifestation improvement rate and a higher clinical cure rate. (12) In addition, meta-analyses of randomized trials (13) and experimental studies (14) of patients with Covid-19 also showed that Lianhua Qingwen Capsule could improve symptoms and pulmonary imaging manifestation, shorten disease course and generate a higher clinical cure rate. Jinhua Qinggan Granule, also a marketed drug for influenza in China, significantly alleviated fever, cough, fatigue and sputum in a small randomized clinical trial with 129 Covid-19 outpatients. ...

... Although the pace of life aggregate did not significantly correlate with the health status of students, it was found that the item regarding less sleep is indeed related to worse health. This comes as no surprise as sleep was found to impact health in previous literature (e.g., Shi et al., 2020). Furthermore, eating slower was related to better health. ...

... If a susceptible individual wears a mask, α is reduced by 85% (Fig. 1A). Our assumption that wearing masks is more effective to reduce transmission than to prevent getting infected is supported by experimental data 25 . However, if both infectious and susceptible individuals wear masks the probability of transmission is the product of these probabilities (0.0075) and, thus, sufficiently low such that transmission is effectively null. ...

... Furthermore, newly instituted regional trauma centers with standardized, optimized managing protocol and dedicated task forces are also playing key roles [8,16]. Yet no reductions in the number of RTCR chest injury deaths have been observed throughout the study period, which underlines the importance of keep strengthening strategies to mitigate key risk factors and to improve road safety [17][18][19][20][21]. ...

... Blood pressure (BP) as one of the modifiable vascular factors was observed to be associated with dementia outcomes in various forms, such as mean measure [3], prehypertension [4], orthostatic hypotension [5], and pulse pressure (PP) [6]. Recently, accumulated evidence indicates that BP variability, which contributes to cerebrovascular damage as an independent factor of mean BP [7], is positively associated with the risk of dementia [2,[8][9][10][11]. ...

... This combination of repurposed drugs is based on the labeled MOA of famotidine and celecoxib as antiin ammatory agents. To distinguish from suboptimal treatment protocols which typically employ inadequate doses of famotidine (Malone, 2021;Shoaibi et al., 2021;Sun et al., 2021), this binary drug combination is referred to as High Dose (HD) famotidine + celecoxib or famcox. ...

... Based on statistics data available from the Global Burden of Diseases, in 2018, ~18,100,000 new cancer cases were diagnosed globally, and nearly a quarter of new cancer cases in women worldwide are breast cancer (3). Furthermore, breast cancer has become the most common malignancy in Chinese women, with an estimated 272,000 women diagnosed and ~70,000 cancer-associated deaths per year (4,5). Alcohol abuse, obesity, a lack of exercise, a later pregnancy or infertility and artificial feeding have been reported to have a marked effect on breast cancer incidence (5). ...