Min Zhou's research while affiliated with Shanghai Jiao Tong University and other places

... Shi et al. performed complex research to evaluate the preclinical efficacy and safety of clinical-grade aerosolized allograft ADMSC-sEVs. On the one hand, the aerosol inhalation of ADMSC-sEVs protects mice against severe pneumonia; on the other hand, it is safe for healthy volunteers and has no severe adverse ADMSCs [76] effects (NCT04313647) [78]. However, the authors used human platelet lysate for sEVs preparation and PEG methods to isolate sEVs which is controversy. ...

... For example, Oxy133, a 20(S)-tertiary alcohol, is an Hh pathway stimulator with robust osteoinductive properties and displays an extended conformation in the crystalline state ( Figure 5B) and in silico, when docked to the Smo binding pocket (unpublished observations). By contrast, Oxy186 and Oxy210, two semi-synthetic oxysterols with strong Hh pathway inhibitory properties, are 20(R)-tertiary alcohols and rigidly held in a bent conformation, the result of steric compression between the angular methyl group at C-18 and the substituents at C-20 [35,36] As Hh signaling can potentially affect inflammatory processes in different tissues [61][62][63][64][65][66], we decided to examine the relationship, if any, between the Hh inhibitory properties and the anti-inflammatory effects displayed by Oxy210. For that purpose, we studied two close analogs of Oxy210, Oxy43, and Oxy234 ( Figure 5B). ...

... NLR>6.90 can be regarded as a relevant and reliable marker in the prediction of in-hospital mortality in AECOPD patients, according to the findings of this study. (54) (55) At a tertiary education hospital, retrospective cross-sectional research was done. The research included previously diagnosed COPD patients who were hospitalized to the hospital with an acute COPD exacerbation (AECOPD). ...

... Manual tracing of LV endocardial borders is time-consuming and dependent on the operator's experience, whereas visual assessment is inherently subjective. Recently, technological advances have led to the availability of some new echocardiographic techniques for more accurate and rapid quantification of volumes, function, and myocardial mechanics [8,9]. Automated function imaging (AFI, GE Healthcare), a novel algorithm of two-dimensional speckle-tracking echocardiography (2D-STE) combined with AI technology, has been introduced to measure LV function [10]. ...

... Taken together, the imaging characteristics of COVID-19 are similar but partially different from early-stage lung cancer presenting as GGOs, which can be recognized by thorough and meticulous examination of CT scan on the first diagnosis in clinics. However, to achieve a reliable diagnosis of early lung cancer and to differentiate it from COVID-19, imaging profiles of suspected patients should be sufficiently understood and comprehensively analyzed combined with clinical manifestations, epidemiological history especially contact history with infectious sources, laboratory tests, pathogen screening, CT re-examination, and pathological analysis acquired from surgical treatment (28). ...

... Nanoparticle concentration per milliliter was 3.74 × 10 11 . Nanoparticle size is an important parameter for biological applications, since it can determine the stability of the delivery system by affecting sedimentation or aggregation rates, as well as cellular internalization and toxicity (Baranowska-Wójcik et al. 2020;Wang et al. 2020). ...

... The assessment of glucose blood levels on hospital admission is of great importance, since infection and hyperglycemia are commonly interconnected. Yi et al. [148] reported the frequency of isolation of nosocomialrelated pathogens in patients on admission to the hospital. The authors found that Enterobacter spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterococcus faecium were likely to be found in both normoglycemic and hyperglycemic individuals or DM patients. ...

... Like for other virus infections, the therapeutic value of convalescent sera that contain neutralizing antibodies to SARS-CoV-2 was evaluated. Although early clinical studies demonstrated improvement of symptoms and viral clearance within an average of 5-6 days in patients receiving convalescent plasma treatment (29)(30)(31)(32), results from recent large-scale trials, such as the RECOVERY Collaborative Group, report the absence of positive outcomes (33,34). With respect to the general associated risks of convalescent plasma therapy regarding blood product transfusion (e.g. ...

... In an initial uncontrolled case series, five critically sick patients with COVID-19 and acute respiratory distress syndrome underwent convalescent plasma treatment, and the result showed improvement in their clinical status (Shen et al. 2020). Later on, Duan et al. (2020) reported that a single dosage of CP (200 mL) was well tolerated and could considerably raise or sustain neutralizing antibodies at a high level, resulting in viremia disappearing in 7 days. However, clinical symptoms improved quickly over 3 days. ...

... The ALT/ AST, prothrombin time, creatinine, D-dimer, CPK, LDH, myohemoglobin and ferritin levels might be increased and elevated relating to a severe disease and thus might help in final assessment of doubtful cases and also to check for the severity. [193,194] On hospitalization, many cases having pneumonia have normal serum procalcitonin levels, but those requiring an intensive care unit (ICU) management, are more likely to display raised levels. In addition, an elevated D-dimer levels and more severe lymphopenia have been shown to be linked with fatality [195]. ...