Min Zhou's research while affiliated with Shanghai Jiao Tong University and other places

Publications (28)

Article
Full-text available
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) turn out to be a promising source of cell-free therapy. Here, we investigated the biodistribution and effect of nebulized human adipose-derived MSC-EVs (haMSC-EVs) in the preclinical lung injury model and explored the safety of nebulized haMSC-EVs in healthy volunteers. DiR-labelled...
Article
Full-text available
Hedgehog (Hh) signaling is involved in early embryogenesis and maintains quiescence in the adult lungs. The interruption of Hh signaling may lead to the development of chronic obstructive pulmonary disease (COPD). The current study aimed to assess whether the Hh pathway affects cigarette-induced emphysema and airway inflammation by regulating infla...
Article
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Lymphangioleiomyomatosis (LAM) is a rare disease characterized by diffuse cystic lesions of the lung. The present study was designed to evaluate the right ventricular (RV) function in LAM patients via single-beat real-time three-dimensional echocardiography (RT-3DE) and to investigate the factors affecting RV function in LAM patients. According to...
Article
Obstructive pulmonary diseases (OPDs) are the leading causes of mortality and disability worldwide. The International Classification of Functioning, Disability and Health (ICF) provides a framework for systematically assessing functioning and disability in patients with chronic diseases. To date, the ICF core sets for OPDs have not been validated b...
Article
Full-text available
Purpose: Frequent exacerbators are a specific phenotype of chronic obstructive pulmonary disease (COPD), whose clinical characteristics and prognostic biomarkers during severe acute exacerbation (AECOPD) have not yet been fully elucidated. The aim of this study was to investigate the clinical features of severe AECOPD in frequent exacerbators and...
Preprint
Full-text available
Purpose: Persistent negative results (at least 3 times) of reverse transcription–polymerase chain reaction (RT-PCR) from pharyngeal swabs are not rare in coronavirus disease 2019 (COVID-19) patients, but their characteristics have not yet been well studied. Methods: PCR confirmed, serum antibody confirmed with persistent negative PCR results, and c...
Article
Herein we develop a unique differentiated-uptake strategy capable of efficient and high-purity isolation of genuine drug-resistant (DR) cells from three types of drug-surviving cancer cells, which include paclitaxel-surviving human ovarian OVCAR-3 cancer cells and human lung carcinoma A549/Taxol cells, and doxorubicin-surviving human immortalized m...
Article
Background: Radiological manifestations of coronavirus disease 2019 (COVID-19) featured ground-glass opacities (GGOs), especially in the early stage, which might create confusion in differential diagnosis with early lung cancer. We aimed to specify the radiological characteristics of COVID-19 and early lung cancer and to unveil the discrepancy bet...
Article
Background: Glucose management is of great significance. Infection and hyperglycemia are a vicious circle. This study was conducted to describe distribution and antimicrobial resistance of bacteria isolated from patients with normoglycemia, hyperglycemia, or diabetes on admission. Methods: A retrospective study was conducted in a teaching hospit...
Article
Full-text available
Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19). In this study, 10 severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL of convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was tra...
Article
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease pro...
Preprint
Full-text available
Background: Chest CT had high sensitivity in diagnosing novel coronavirus pneumonia (NCP) at early stage, giving it an advantage over nucleic acid detection in time of crisis. Deep learning was reported to discover intricate structures from clinical images and achieve expert-level performance in medical image analysis. To develop and validate an in...
Preprint
Full-text available
Currently, there are no approved specific antiviral agents for 2019 novel coronavirus disease (COVID-19). In this study, ten severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was trans...
Article
Objective To evaluate the feasibility of new retrievable covered metallic segmented Y airway stents modified with three-dimensional (3D) printing for gastro-respiratory fistula involving carina or main bronchi. Methods We designed a new retrievable covered metallic segmented Y airway stent to fit the anatomical characteristics of the carina region...
Article
Background: In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. Methods: In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospit...
Article
We report a case of community-acquired pneumonia in a patient in China. We verified Legionella pneumophila infection through next-generation sequencing of blood, sputum, and pleural effusion samples. Our results show the usefulness of next-generation sequencing and of testing different samples early in the course of illness to identify this bacteri...
Article
Full-text available
Objective The aim of this study was to further clarify clinical characteristics and predict mortality risk among patients with viral pneumonia.MethodsA total of 528 patients with viral pneumonia at RuiJin hospital in Shanghai from May 2015 to May 2019 were recruited. Multiplex real-time RT-PCR was used to detect respiratory viruses. Demographic inf...
Article
Next‐generation sequencing of cell‐free circulating DNA (cfDNA) has emerged as promising technique for identifying minimally invasive genomic profiling of tumor cells recently. However, it remains relatively unknown in LAM disease. In this study, paired cfDNA and genomic DNA (gDNA) in blood samples were obtained from 23 LAM patients and 7 healthy c...
Article
Full-text available
Purpose: To investigate antimicrobial resistance and risk factors for mortality of Klebsiella pneumoniae (KP) pneumonia in diabetics and nondiabetics. Patients and methods: A retrospective study was conducted among inpatients of KP pneumonia via electronic medical records in a territory hospital between January 2016 and June 2018. Antimicrobial res...
Article
Background: Pulmonary lymphoma arises primarily from the lung, which is extremely rare, or be secondarily involved by lymphoma. The clinical features, management, and prognostic factors have not been clearly identified. Methods: Sixty-three patients with primary pulmonary lymphoma (PPL) and 117 patients with secondary pulmonary lymphoma (SPL) tr...
Article
Full-text available
In order to determine the validity of the International Classification of Functioning, Disability, and Health brief Core Set for Obstructive Pulmonary Disease (ICF-OPD) for the assessment of functioning and environmental factors in Chinese chronic OPD (COPD) patients, we conducted a cross-sectional study with a convenience sample of 100 COPD patien...
Article
Full-text available
Background: The glucagon-like peptide-1 receptor (GLP-1R) agonist - liraglutide (LIR) - is an insulin secretagogue for the treatment of diabetes and has been proven to have therapeutic potential in the treatment of COPD. Evidence suggested that activating GLP-1R signaling might have immunomodulating and anti-inflammatory effects. COPD is character...
Article
The functional role of respiratory microbiota has attracted an accumulating attention recently. However, the role of respiratory microbiome in lung carcinogenesis is mostly unknown. This study aimed to characterize and compare bilateral lower airway microbiome of lung cancer patients with unilateral lobar masses and control subjects. Protected bron...

Citations

... Shi et al. performed complex research to evaluate the preclinical efficacy and safety of clinical-grade aerosolized allograft ADMSC-sEVs. On the one hand, the aerosol inhalation of ADMSC-sEVs protects mice against severe pneumonia; on the other hand, it is safe for healthy volunteers and has no severe adverse ADMSCs [76] effects (NCT04313647) [78]. However, the authors used human platelet lysate for sEVs preparation and PEG methods to isolate sEVs which is controversy. ...
... For example, Oxy133, a 20(S)-tertiary alcohol, is an Hh pathway stimulator with robust osteoinductive properties and displays an extended conformation in the crystalline state ( Figure 5B) and in silico, when docked to the Smo binding pocket (unpublished observations). By contrast, Oxy186 and Oxy210, two semi-synthetic oxysterols with strong Hh pathway inhibitory properties, are 20(R)-tertiary alcohols and rigidly held in a bent conformation, the result of steric compression between the angular methyl group at C-18 and the substituents at C-20 [35,36] As Hh signaling can potentially affect inflammatory processes in different tissues [61][62][63][64][65][66], we decided to examine the relationship, if any, between the Hh inhibitory properties and the anti-inflammatory effects displayed by Oxy210. For that purpose, we studied two close analogs of Oxy210, Oxy43, and Oxy234 ( Figure 5B). ...
... NLR>6.90 can be regarded as a relevant and reliable marker in the prediction of in-hospital mortality in AECOPD patients, according to the findings of this study. (54) (55) At a tertiary education hospital, retrospective cross-sectional research was done. The research included previously diagnosed COPD patients who were hospitalized to the hospital with an acute COPD exacerbation (AECOPD). ...
... Manual tracing of LV endocardial borders is time-consuming and dependent on the operator's experience, whereas visual assessment is inherently subjective. Recently, technological advances have led to the availability of some new echocardiographic techniques for more accurate and rapid quantification of volumes, function, and myocardial mechanics [8,9]. Automated function imaging (AFI, GE Healthcare), a novel algorithm of two-dimensional speckle-tracking echocardiography (2D-STE) combined with AI technology, has been introduced to measure LV function [10]. ...
... Taken together, the imaging characteristics of COVID-19 are similar but partially different from early-stage lung cancer presenting as GGOs, which can be recognized by thorough and meticulous examination of CT scan on the first diagnosis in clinics. However, to achieve a reliable diagnosis of early lung cancer and to differentiate it from COVID-19, imaging profiles of suspected patients should be sufficiently understood and comprehensively analyzed combined with clinical manifestations, epidemiological history especially contact history with infectious sources, laboratory tests, pathogen screening, CT re-examination, and pathological analysis acquired from surgical treatment (28). ...
... Nanoparticle concentration per milliliter was 3.74 × 10 11 . Nanoparticle size is an important parameter for biological applications, since it can determine the stability of the delivery system by affecting sedimentation or aggregation rates, as well as cellular internalization and toxicity (Baranowska-Wójcik et al. 2020;Wang et al. 2020). ...
... The assessment of glucose blood levels on hospital admission is of great importance, since infection and hyperglycemia are commonly interconnected. Yi et al. [148] reported the frequency of isolation of nosocomialrelated pathogens in patients on admission to the hospital. The authors found that Enterobacter spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterococcus faecium were likely to be found in both normoglycemic and hyperglycemic individuals or DM patients. ...
... Like for other virus infections, the therapeutic value of convalescent sera that contain neutralizing antibodies to SARS-CoV-2 was evaluated. Although early clinical studies demonstrated improvement of symptoms and viral clearance within an average of 5-6 days in patients receiving convalescent plasma treatment (29)(30)(31)(32), results from recent large-scale trials, such as the RECOVERY Collaborative Group, report the absence of positive outcomes (33,34). With respect to the general associated risks of convalescent plasma therapy regarding blood product transfusion (e.g. ...
... In an initial uncontrolled case series, five critically sick patients with COVID-19 and acute respiratory distress syndrome underwent convalescent plasma treatment, and the result showed improvement in their clinical status (Shen et al. 2020). Later on, Duan et al. (2020) reported that a single dosage of CP (200 mL) was well tolerated and could considerably raise or sustain neutralizing antibodies at a high level, resulting in viremia disappearing in 7 days. However, clinical symptoms improved quickly over 3 days. ...
... The ALT/ AST, prothrombin time, creatinine, D-dimer, CPK, LDH, myohemoglobin and ferritin levels might be increased and elevated relating to a severe disease and thus might help in final assessment of doubtful cases and also to check for the severity. [193,194] On hospitalization, many cases having pneumonia have normal serum procalcitonin levels, but those requiring an intensive care unit (ICU) management, are more likely to display raised levels. In addition, an elevated D-dimer levels and more severe lymphopenia have been shown to be linked with fatality [195]. ...