December 2024
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3 Reads
Annals of Clinical Nutrition and Metabolism
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December 2024
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3 Reads
Annals of Clinical Nutrition and Metabolism
October 2024
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20 Reads
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1 Citation
Annals of Liver Transplantation
June 2023
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3 Reads
Annals of Hepato-Biliary-Pancreatic Surgery
November 2022
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6 Reads
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3 Citations
Asian Journal of Surgery
Objective Postoperative nausea and vomiting are regarded as a serious concern after thyroidectomy. Electroacupuncture shows the potential to reduce general anesthesia-related side effects. The aim of this study was to evaluate the efficacy of electroacupuncture in preventing postoperative nausea and vomiting that commonly occurs in patients after thyroidectomy. Methods This study was a prospective randomized controlled trial with a two-arm, patient blind structure. Sixty-four participants were randomly assigned to the acupuncture (n = 35) or control (n = 29) group. Patients in the acupuncture group received electroacupuncture and intradermal press needles. The primary endpoint was the incidence and severity of postoperative nausea and vomiting, and secondary endpoints were the length of hospital stay, pain severity, and postoperative in-hospital morbidity. Results The total incidence of postoperative nausea and vomiting was 40.6% (26/64). There was no difference in the incidence between the control (10/29, 34.5%) and acupuncture (16/35, 45.7%) groups (p = 0.362). The severity of postoperative nausea and vomiting was not different between the groups (p = 0.842). Length of hospitalization and postoperative complications were not different between the groups. Conclusion In this randomized controlled trial, electroacupuncture treatment after thyroidectomy is safe and comparable to conventional anti-emetic therapy. Trial registration Clinical Research Information Service, KCT0001782. Registered on 26 January 2016.
June 2022
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23 Reads
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17 Citations
Molecular and Cellular Biochemistry
TyG (triglyceride and glucose) index using triglyceride and fasting blood glucose is recommended as a useful marker for insulin resistance. To clarify whether the TyG index is a marker for predicting metabolic syndrome (MetS) and to investigate the importance of single-nucleotide polymorphisms (SNPs) in MetS diagnosis. From 2001 to 2014, a longitudinal prospective cohort study of 3580 adults aged 40–70 years was conducted. The area under the receiver operating characteristic curves (AUROC) and Youden index (YI) was calculated to assess the diagnostic value. During the 14-year follow-up, 1270 subjects developed MetS. Five SNPs in four genes (BUD13 rs10790162, ZPR1 rs2075290, APOA5 rs2266788, APOA5 rs2075291, and MKL1 rs4507196) significantly correlated with susceptibility to MetS (p < 0.00005). The areas under the curve of TyG index and HOMA-IR were 0.854 (95% confidence interval [CI], 0.841–0.867) and 0.702 (95% CI, 0.684–0.721), respectively. Despite no statistical significance, AUROC and YI were increased when MetS was diagnosed using TyG index and the five SNPs. TyG index might be useful for identifying individuals at high risk of developing MetS. The combination of TyG index and SNPs showed better diagnostic accuracy than TyG index alone, indicating the potential value of novel SNPs for MetS diagnosis.
June 2022
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13 Reads
Asian Journal of Surgery
May 2022
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99 Reads
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3 Citations
Background and Objectives: The molecular mechanisms of the development of acute kidney injury (AKI) after kidney transplantation are not yet clear. The aim of this study was to confirm the genes and mechanisms related to AKI after transplantation. Materials and Methods: To investigate potential genetic targets for AKI, an analysis of the gene expression omnibus database was used to identify key genes and pathways. After identification of differentially expressed genes, Kyoto Encyclopedia of Genes and Genome pathway enrichment analyses were performed. We identified the hub genes and established the protein–protein interaction network. Results: Finally, we identified 137 differentially expressed genes (59 upregulated genes and 16 downregulated genes). AKAP12, AMOT, C3AR1, LY96, PIK3AP1, PLCD4, PLCG2, TENM2, TLR2, and TSPAN5 were filtrated by the hub genes related to the development of post-transplant AKI from the Protein–Protein Interaction (PPI) network. Conclusions: This may provide important evidence of the diagnostic and therapeutic biomarker of AKI.
May 2022
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5 Reads
Asian Journal of Surgery
April 2022
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3 Reads
Annals of Hepato-Biliary-Pancreatic Surgery
April 2022
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2 Reads
Annals of Hepato-Biliary-Pancreatic Surgery
... In this context, Choi et al. [5] investigated the characteristics of different centers and regional differences in ALD-LT by analyzing data from 19 centers across Korea. The authors effectively identified the rates of ALD-LT according to center and region. ...
October 2024
Annals of Liver Transplantation
... Furthermore, the mechanisms of acupuncture also include the regulation of serotonin levels, bile acid metabolism, and gut microbiota, which can alleviate gastrointestinal discomfort caused by certain medications. 11,12 The mechanism of the combined effects of acupuncture and pharmacotherapy is a complex and synergistic process that integrates the strengths of both treatments, enhancing therapeutic efficacy and reducing side effects through interaction and complementarity. Many clinical and basic studies have confirmed that the combined use of acupuncture and medication demonstrates superior effectiveness in lowering blood glucose and alleviating medication-related side effects. ...
November 2022
Asian Journal of Surgery
... p < 0.001). Kang et al. also reported on a large Korean group for a longer duration of 14 years and showed again that the TyG index was significantly superior to HOMA-IR in predicting MetS and displayed greater sensitivity and specificity [16]. In the smaller study by D'Elia et al. that only reported on Italian males, they showed that the TyG index was similar to HOMA-IR in predicting MetS [17]. ...
June 2022
Molecular and Cellular Biochemistry
... However, while the study did include a certain number of HCC patients, it did not provide a definitive understanding of the association between sarcopenia and HCC [4]. Recently, several studies have demonstrated that sarcopenia is associated with reduced survival in patients with advanced HCC undergoing sorafenib treatment [3,[5][6][7]. In an issue of the Annals of Clinical Nutrition and Metabolism, Lee and Park [5] examined the clinical significance of sarcopenia in patients with advanced HCC undergoing sorafenib treatment. ...
December 2021
Annals of Clinical Nutrition and Metabolism
... However, Park et al. used electroacupuncture to stimulate Zusanli and Neiguan 1 hour before and 6 hours after thyroidectomy in an experiment to study electroacupuncture to prevent nausea and vomiting after thyroidectomy. The results showed that electroacupuncture did not affect the incidence of PONV within 36 hours after surgery [43]. Therefore, the timing of stimulation with electroacupuncture to prevent PONV is still unclear. ...
August 2020
... Preoperative sarcopenia was not significantly associated with LN metastasis, which may be the reason for the lack of significant association between high TNM stage on adjusted logistic regression analysis, despite a significant association on unadjusted analysis. In addition, the association between sarcopenia and LN metastasis seems to vary according to the type of cancer [28][29][30][31] . Sarcopenia has been shown to increase the risk of LN metastasis in colorectal cancer and advanced urothelial carcinoma, but not in resectable bile duct cancer or recurrent pancreas adenocarcinoma [28][29][30][31] . ...
December 2019
Surgical Metabolism and Nutrition
... Interpretation of immunostaining. p16 immunoreactivity was interpreted as block-positive when p16 expression was continuous and strong with nuclear or nuclear and cytoplasmic staining (25,26). All other p16 expression patterns described as focal nuclear staining or wispy, blob-like, puddled, or scattered cytoplasmic staining were interpreted as patchy positive. ...
September 2019
... Our study discovered that Hes-NPs had a protective effect on liver tissue injury. This is achieved by enhancing the body's ability to handle oxidative stress, suppressing inflammatory responses, and decreasing apoptosis through the deactivation of the TNF-α pathway [72,73]. ...
September 2019
Transplantation Proceedings
... Additionally, inconsistencies in how DL was used, such as differences in wavelength or technique, make it challenging to draw universal conclusions. Some studies also had relatively small sample sizes, which may introduce bias and reduce reliability (334)(335)(336)(337)(338). To overcome these issues, more extensive, welldesigned clinical trials with standardized methodologies are necessary. ...
September 2019
Transplantation Proceedings
... [10,11] Eosinophils play critical roles in the development of allergic rhinitis (AR) by release cytokines tumor necrosis factor alfa(TNF-α) has been discovered that tumor necrosis factor alfa plays a role in the inflammatory response [12]. TNF-α is controlled by the TNF-α gene [13]. ...
June 2019
Genetic Testing and Molecular Biomarkers