Min-Su Park’s research while affiliated with Kyung Hee University and other places

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Publications (67)


Triglyceride-glucose index predicts future metabolic syndrome in an adult population, Korea: a prospective cohort study
  • Article

December 2024

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3 Reads

Annals of Clinical Nutrition and Metabolism

Min-Su Park



Efficacy of electroacupuncture in preventing nausea and vomiting after thyroidectomy: A prospective randomized controlled trial

November 2022

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6 Reads

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3 Citations

Asian Journal of Surgery

Objective Postoperative nausea and vomiting are regarded as a serious concern after thyroidectomy. Electroacupuncture shows the potential to reduce general anesthesia-related side effects. The aim of this study was to evaluate the efficacy of electroacupuncture in preventing postoperative nausea and vomiting that commonly occurs in patients after thyroidectomy. Methods This study was a prospective randomized controlled trial with a two-arm, patient blind structure. Sixty-four participants were randomly assigned to the acupuncture (n = 35) or control (n = 29) group. Patients in the acupuncture group received electroacupuncture and intradermal press needles. The primary endpoint was the incidence and severity of postoperative nausea and vomiting, and secondary endpoints were the length of hospital stay, pain severity, and postoperative in-hospital morbidity. Results The total incidence of postoperative nausea and vomiting was 40.6% (26/64). There was no difference in the incidence between the control (10/29, 34.5%) and acupuncture (16/35, 45.7%) groups (p = 0.362). The severity of postoperative nausea and vomiting was not different between the groups (p = 0.842). Length of hospitalization and postoperative complications were not different between the groups. Conclusion In this randomized controlled trial, electroacupuncture treatment after thyroidectomy is safe and comparable to conventional anti-emetic therapy. Trial registration Clinical Research Information Service, KCT0001782. Registered on 26 January 2016.


Prevalence of metabolic syndrome according to HOMA-IR and TyG index quartile
a HOMA-IR has a nonlinear relationship with the fitted value of MetS. b TyG index has a linear relationship with the fitted value of MetS and area of 95% CI is narrower than HOMA-IR
Comparing the area under the receiver operating characteristic curves between the Tyg index and other indices to predict Mets
Risk prediction of the metabolic syndrome using TyG Index and SNPs: a 10-year longitudinal prospective cohort study
  • Article
  • Publisher preview available

June 2022

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23 Reads

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17 Citations

Molecular and Cellular Biochemistry

TyG (triglyceride and glucose) index using triglyceride and fasting blood glucose is recommended as a useful marker for insulin resistance. To clarify whether the TyG index is a marker for predicting metabolic syndrome (MetS) and to investigate the importance of single-nucleotide polymorphisms (SNPs) in MetS diagnosis. From 2001 to 2014, a longitudinal prospective cohort study of 3580 adults aged 40–70 years was conducted. The area under the receiver operating characteristic curves (AUROC) and Youden index (YI) was calculated to assess the diagnostic value. During the 14-year follow-up, 1270 subjects developed MetS. Five SNPs in four genes (BUD13 rs10790162, ZPR1 rs2075290, APOA5 rs2266788, APOA5 rs2075291, and MKL1 rs4507196) significantly correlated with susceptibility to MetS (p < 0.00005). The areas under the curve of TyG index and HOMA-IR were 0.854 (95% confidence interval [CI], 0.841–0.867) and 0.702 (95% CI, 0.684–0.721), respectively. Despite no statistical significance, AUROC and YI were increased when MetS was diagnosed using TyG index and the five SNPs. TyG index might be useful for identifying individuals at high risk of developing MetS. The combination of TyG index and SNPs showed better diagnostic accuracy than TyG index alone, indicating the potential value of novel SNPs for MetS diagnosis.

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Venn diagram of DEGs common to all three GEO datasets. DEGs, differentially expressed genes; GEO, Gene Expression Omnibus.
GO and KEGG enrichment analysis of DEGs. (A) CC functional classification terms of genes. (B) BP functional classification terms of genes. (C) MF functional classification terms of genes (D) KEGG analysis of genes. BP, biological process; CC, cellular component; DEGs, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; MF, molecular function.
Overall protein–protein interaction network of the 137 identified DEGs.
Overall protein–protein interaction network of top 10 genes with the highest connectivity.
Top 10 hub genes with higher degrees of connectivity.
Identification of Multiple Hub Genes in Acute Kidney Injury after Kidney Transplantation by Bioinformatics Analysis

May 2022

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99 Reads

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3 Citations

Background and Objectives: The molecular mechanisms of the development of acute kidney injury (AKI) after kidney transplantation are not yet clear. The aim of this study was to confirm the genes and mechanisms related to AKI after transplantation. Materials and Methods: To investigate potential genetic targets for AKI, an analysis of the gene expression omnibus database was used to identify key genes and pathways. After identification of differentially expressed genes, Kyoto Encyclopedia of Genes and Genome pathway enrichment analyses were performed. We identified the hub genes and established the protein–protein interaction network. Results: Finally, we identified 137 differentially expressed genes (59 upregulated genes and 16 downregulated genes). AKAP12, AMOT, C3AR1, LY96, PIK3AP1, PLCD4, PLCG2, TENM2, TLR2, and TSPAN5 were filtrated by the hub genes related to the development of post-transplant AKI from the Protein–Protein Interaction (PPI) network. Conclusions: This may provide important evidence of the diagnostic and therapeutic biomarker of AKI.





Citations (32)


... In this context, Choi et al. [5] investigated the characteristics of different centers and regional differences in ALD-LT by analyzing data from 19 centers across Korea. The authors effectively identified the rates of ALD-LT according to center and region. ...

Reference:

Liver transplantation for alcohol-related liver disease in Korea: The need for patient management guidelines
Varied strategies for alcohol-related liver transplants in South Korea
  • Citing Article
  • October 2024

Annals of Liver Transplantation

... Furthermore, the mechanisms of acupuncture also include the regulation of serotonin levels, bile acid metabolism, and gut microbiota, which can alleviate gastrointestinal discomfort caused by certain medications. 11,12 The mechanism of the combined effects of acupuncture and pharmacotherapy is a complex and synergistic process that integrates the strengths of both treatments, enhancing therapeutic efficacy and reducing side effects through interaction and complementarity. Many clinical and basic studies have confirmed that the combined use of acupuncture and medication demonstrates superior effectiveness in lowering blood glucose and alleviating medication-related side effects. ...

Efficacy of electroacupuncture in preventing nausea and vomiting after thyroidectomy: A prospective randomized controlled trial
  • Citing Article
  • November 2022

Asian Journal of Surgery

... p < 0.001). Kang et al. also reported on a large Korean group for a longer duration of 14 years and showed again that the TyG index was significantly superior to HOMA-IR in predicting MetS and displayed greater sensitivity and specificity [16]. In the smaller study by D'Elia et al. that only reported on Italian males, they showed that the TyG index was similar to HOMA-IR in predicting MetS [17]. ...

Risk prediction of the metabolic syndrome using TyG Index and SNPs: a 10-year longitudinal prospective cohort study

Molecular and Cellular Biochemistry

... However, while the study did include a certain number of HCC patients, it did not provide a definitive understanding of the association between sarcopenia and HCC [4]. Recently, several studies have demonstrated that sarcopenia is associated with reduced survival in patients with advanced HCC undergoing sorafenib treatment [3,[5][6][7]. In an issue of the Annals of Clinical Nutrition and Metabolism, Lee and Park [5] examined the clinical significance of sarcopenia in patients with advanced HCC undergoing sorafenib treatment. ...

Clinical Significance of Sarcopenia in Patients with Advanced Hepatocellular Carcinoma Undergoing Sorafenib Treatment
  • Citing Article
  • December 2021

Annals of Clinical Nutrition and Metabolism

... However, Park et al. used electroacupuncture to stimulate Zusanli and Neiguan 1 hour before and 6 hours after thyroidectomy in an experiment to study electroacupuncture to prevent nausea and vomiting after thyroidectomy. The results showed that electroacupuncture did not affect the incidence of PONV within 36 hours after surgery [43]. Therefore, the timing of stimulation with electroacupuncture to prevent PONV is still unclear. ...

Efficacy of Electroacupuncture in Preventing Nausea and Vomiting After Thyroidectomy: a Prospective Randomized Controlled Trial

... Preoperative sarcopenia was not significantly associated with LN metastasis, which may be the reason for the lack of significant association between high TNM stage on adjusted logistic regression analysis, despite a significant association on unadjusted analysis. In addition, the association between sarcopenia and LN metastasis seems to vary according to the type of cancer [28][29][30][31] . Sarcopenia has been shown to increase the risk of LN metastasis in colorectal cancer and advanced urothelial carcinoma, but not in resectable bile duct cancer or recurrent pancreas adenocarcinoma [28][29][30][31] . ...

Relationship of Sarcopenia with the Outcomes of Patients who Underwent Surgery for Bile Duct Cancer

Surgical Metabolism and Nutrition

... Interpretation of immunostaining. p16 immunoreactivity was interpreted as block-positive when p16 expression was continuous and strong with nuclear or nuclear and cytoplasmic staining (25,26). All other p16 expression patterns described as focal nuclear staining or wispy, blob-like, puddled, or scattered cytoplasmic staining were interpreted as patchy positive. ...

Tumor-specific Expression of Insulin-like Growth Factor II mRNA-binding Protein 3 Independently Predicts Worse Survival of Patients With Adenocarcinoma of the Ampulla of Vater
  • Citing Article
  • September 2019

... Our study discovered that Hes-NPs had a protective effect on liver tissue injury. This is achieved by enhancing the body's ability to handle oxidative stress, suppressing inflammatory responses, and decreasing apoptosis through the deactivation of the TNF-α pathway [72,73]. ...

Hesperidin Ameliorates Hepatic Ischemia-Reperfusion Injury in Sprague-Dawley Rats
  • Citing Article
  • September 2019

Transplantation Proceedings

... Additionally, inconsistencies in how DL was used, such as differences in wavelength or technique, make it challenging to draw universal conclusions. Some studies also had relatively small sample sizes, which may introduce bias and reduce reliability (334)(335)(336)(337)(338). To overcome these issues, more extensive, welldesigned clinical trials with standardized methodologies are necessary. ...

Protective Effect of Citric Acid Against Hepatic Ischemia Reperfusion Injury in Sprague-Dawley Rats
  • Citing Article
  • September 2019

Transplantation Proceedings

... [10,11] Eosinophils play critical roles in the development of allergic rhinitis (AR) by release cytokines tumor necrosis factor alfa(TNF-α) has been discovered that tumor necrosis factor alfa plays a role in the inflammatory response [12]. TNF-α is controlled by the TNF-α gene [13]. ...

Promoter Polymorphism (−308G/A) of Tumor Necrosis Factor-Alpha ( TNF-α ) Gene and Asthma Risk: An Updated Meta-Analysis
  • Citing Article
  • June 2019

Genetic Testing and Molecular Biomarkers