Mikio Sawada's research while affiliated with Jichi Medical University and other places
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Publications (16)
Rosai-Dorfman disease (RDD) is a benign histiocytic proliferative disorder characterized by the accumulation of histiocytes in lymph nodes and various other organs. RDD seldom involves the central nervous system, and cases of purely intracranial RDD are particularly rare. We report a case of purely intracranial RDD involving the brainstem that was...
Botulism is a neuroparalytic disease caused by neurotoxins produced by Clostridium botulinum. Food-borne botulism is a kind of exotoxin-caused food intoxication. Although this disease is rarely reported in Japan now, it is a cause of great concern because of its high mortality rate, and botulism cases should be treated as a public health emergency....
A 65-year-old right-handed man noted a sudden onset of numbness and weakness of the right hand. On the initial visit to our hospital, he showed severe acalculia, and transient agraphia (so called incomplete Gerstmann syndrome) and transcortical sensory aphasia. Brain MRI revealed a fresh infarct in the left middle frontal gyrus. The paragraphia and...
We previously suggested that P15 in median nerve SEPs is generated by thalamocortical fibers by the mechanism of the junctional potential. In this study, we examined five normal subjects using long-distance bipolar leads over the scalp and aimed to further elucidate the nature of the P15 potential as a junctional potential. As a result, negative po...
A 54-year-old man with a history of partially dissected epidermoid cyst in the left cerebellopontine angle suffered from a slowly progressive dysesthesia and weakness in the lower extremities and trunk. Neurological examination revealed segmental muscular weakness and sensory disturbance in those regions, giving rise to the possibility of monoradic...
To record N18 in median somatosensory evoked potentials (SEPs) for deeply comatose or brain dead patients and to demonstrate the usefulness of N18 for the diagnosis of brain death in comparison with auditory brain stem responses (ABRs) and P13/14 in median SEPs, which have been conventionally used as complementary tests for the diagnosis of brain d...
Citations
... Following previous studies, the gender distribution showed a slight male predilection (two-thirds of PIRDDs were males) [45]. Contrary to the literature [8,39], PIRDD occurred in different age groups and was more predilection for older people [2,14]. A wide range of variations in radiological images have been previously reported [38,42,50]. ...
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... 9 Ando et al. reported that Gerstmann syndrome did not only develop due to left angular gyrus dysfunction but could also occur in left middle frontal gyrus lesions. 10 Sakurai et al., because of their evaluations on three patients in 2010, reported that only agraphia occurs in the angular gyrus lesion, but agraphia and alexia occurs in the lesions when extending from the angular gyrus to the middle occipital gyrus. 11À13 Koseoglu et al. agreed with Gerstmann in their case report in 2014. ...
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... Glucocorticoid therapy must be started early after onset of symptoms to shorten the time of recovery. [26][27][28][29] Facial palsy may resolve in 2 weeks with IVIG therapy. 10 The bulbar palsy implies the involvement of lower cranial nerves IX, X, XI, and XII. ...
... EP includes visual evoked potentials (VEP), somatosensory evoked potentials (SSEP), and/or and auditory evoked potentials (AEP). EPs in general have been proposed as a complement to EEG, given their ability to evaluate the integrity of an entire pathway, from peripheral stimulus to cortical output, particularly of the brainstem [91][92][93]. Although they also rely on interpretation by a skilled provider, they require less time and resource input. ...
Reference: Brain death: a clinical overview
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... Usually, however, an autopsy in meningeal carcinomatosis may show squamous-type carcinoma cells scattered in the cerebro-spinal leptomeninges and perineurium of almost all spinal and cranial nerve roots, causing severe axonal degeneration. [119] Involvement of the leptomeninges in lymphomatoid granulomatosis may also damage LCN. [120] Bone metastases of the base of the skull, which are usually painful, are a frequent cause of LCN dysfunction including Collet-Sicard-syndrome. [108,121] The most frequent neoplasms of the jugular foramen are the paragangliomas, [113] followed by Schwannomas, [122] neuroendocrine carcinoma, [123] and meningeomas. ...
Reference: Disorders of the lower cranial nerves
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272217871220765-1441913206719_Q64/Haruo-Shimazaki.jpg)
