Michael Wahl's research while affiliated with University of Illinois at Chicago and other places

Publications (24)

Article
Boric acid is a white powder or colorless crystal that is a weak acid of boron. It was previously used as an antiseptic and is now more frequently used as an insecticide and in a number of manufacturing processes. In small acute ingestions, it is generally benign but massive ingestion or repeated exposures can cause a toxicity characterized by gast...
Article
Intravenous fat emulsion (IFE) therapy is a novel treatment that has been used to reverse the acute toxicity of some xenobiotics with varied success. We sought to determine how US Poison Control Centers (PCCs) have incorporated IFE as a treatment strategy for poisoning. A closed-format multiple-choice survey instrument was developed, piloted, revis...
Article
Severe hepatotoxicity in acute acetaminophen overdose in children is uncommon. This apparent protection does not extend to chronic or repeated high dose acetaminophen administration. The Illinois Poison Center (IPC) was consulted on a case involving a 7 month old 17 lb infant, who had presented the day prior to an emergency department with complain...
Article
Heightened toxicovigilance since the terrorist actions of 9/11 has raised concerns for malicious use of highly toxic botanicals, as the 3 cases reported illustrate.

Citations

... Atropine. Atropine is a symptomatic antidote for the muscarinic signs and symptoms of nerve agent poisonings (22). Atropine is a competitive antagonist at muscarinic receptors only and thus blocks the effects of acetylcholine at muscarinic receptors in the PNS and central nervous system. ...
... Hyperinsulinemia euglycemia (HIE) and intravenous fat emulsion (IFE) are two interventions that may be beneficial in the treatment of CCB and BB overdose [2,3]. Many poison control centers (PCC) are now recommending their use following overdose of BB and CCB [4,5]. The goal of this study was to determine how often HIE and IFE were recommended by a statewide PCC for CCB and BB intoxications, how often those recommendations were implemented, and whether the use of a faxable treatment protocol influenced provider adherence to PCC recommendations. ...
... Four studies exploring the prevalence of calls to poison centers or visits to an emergency department, as a consequence of human exposure to synthetic cannabinoids, were identifi ed. In a sample of calls received during 2011 at the Illinois Poison Center in the United States [50], the distribution of the calls between rural and urban areas was studied. The prevalence of synthetic cannabinoid exposure cases was 8.43 per 100,000 inhabitants in the rural areas, and 1.37 per 100,000 inhabitants in the large metropolitan areas. ...
... The first case report describing the use of intravenous lipid emulsion (ILE) therapy as a rescue or antidotal therapy for acute intoxication was published in 2006 (3). In recent years, it has become one of the most recommended treatment methods for patients who have experienced cardiac arrest or those with high hemodynamic risk following xenobiotic toxicity (4). ...
... Neonatal poisoning from paracetamol resulted from transplacental drug transfer after maternal overdose in some published case reports (Table 1) [4][5][6][7][8][9][10][11][12][13], while, in others, paracetamol poisoning occurred in neonates and infants as a result of medication errors (Table 2) [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. ...
... 4,5 In addition, due to the alleged anabolic and lipolytic properties and protein synthesis stimulating effects, clenbuterol is illicitly used by bodybuilders or athletes and in livestock breeding to increase muscle mass. 6,7 Consequently, outbreaks of clenbuterol intoxication for consuming contaminated meat occurred in some areas of the world. 8,9 Human case reports of clenbuterol intoxication in weight-losing and performance-enhancing bodybuilders or athletes also appear occasionally. ...
... Present advice is to use doses up to 5 g pyridoxine, normally given as an equal mass dose to the ingested isoniazid up to this initial maximum, to restore synthesis of GABA. This empirical dosing approach appears to reduce the risk of adverse events with pyridoxine seen after higher dose infusions [40]. Isoniazid is a rare poisoning and lack of rapid availability of i.v. ...
... RRT has been effective in the management of various medication related toxicities [28][29][30][31][32][33][34][35][36][37][38][39][40][41][60][61][62][63][64][65][66]. It is important to note that scientific data is limited to case reports and case series. ...
... In 1782, the Swedish chemist Carl Wilhelm Scheele first isolated hydrogen cyanide from the Prussian blue pigment [4]. Hydrogen cyanide was used on the battlefield during World War I and later for genocide by Germans during World War II [5]. Potassium cyanide was used in the 1978 Jonestown mass suicide, in which more than 900 people died [6]. ...
... Siloxane polymers may cause adverse effects via inhalation. It may induce pulmonary toxicity secondary to aspiration, especially in young children due to widely used PCPs (159). Cyclosiloxanes, especially octamethylcyclotetrasiloxane (D4) in low concentration, show ERα affinity and a weak estrogenic activity (160). ...