Michael Ristow's research while affiliated with ETH Zurich and other places
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Publications (18)
Calcium (Ca²⁺) and reactive oxygen species (ROS) are versatile signaling molecules coordinating physiological and pathophysiological processes. While channels and pumps shuttle Ca²⁺ ions between extracellular space, cytosol and cellular compartments, short-lived and highly reactive ROS are constantly generated by various production sites within the...
Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Di...
The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacolo...
Table S1 Mouse qPCR primer sequences.
Fig. S1 Insulin receptor (IR) expression is reduced in peripheral tissue from PerIRKO−/− and PerIRKO−/+ mice.
Fig. S2 The effect of complete peripheral tissue IR disruption on body composition and blood glucose regulation in adult mice.
Fig. S3 Partial peripheral tissue IR disruption does not affect glucose tolerance or insulin secretion of adult...
Processing and intermediate metabolism of macronutrients are essential components of any life. Facultative or obligatory conversion of carbohydrates as well as fatty and amino acids into readily available energy equivalents like ATP are tightly regulated. Our interest is focused on the role of specific amino acids and glucose metabolites on nematod...
Supplementary Figures 1-3 and Supplementary Tables 1-7
Differentially expressed genes D. rerio
Differentially expressed genes M. musculus
Differentially expressed genes C. elegans
Differentially expressed genes: control RNAi versus bcat-1 RNAi
Citations
... Calcium (Ca 2+ ) storage in the ER plays a central role in pro-survival and cell death by regulating various intracellular signaling pathways [35]. In addition, excessive ROS and intracellular Ca 2+ release induces apoptosis in diverse cancers; thus, targeting ROS and Ca 2+ is a potential anti-cancer therapeutic strategy [36,37]. Moreover, accumulating reports suggest that ROS and Ca 2+ generation regulate cell death by inducing the ER stress signaling pathway [38]. ...
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... The high-dimensionality appreciation of human physiological and pathological mechanisms is continuously improving, leading to an elevation in lifespan throughout the world. Aging-related diseases are now a prominent feature in our society [1][2][3]. Chronic kidney disease (CKD), diabetes mellitus and osteoporosis are three examples of highly prevalent aging-related disorders that demonstrate multiple intertwined gerontological pathomechanisms. Patients afflicted with these conditions unfortunately often die from severe cardiovascular complications, including arterial media calcification, rather than from the primary disease itself [4][5][6]. ...
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... Brouns et al. [53] concluded that a non-ketogenic diet of 100-150 g of carbohydrate per day is more practical for weight loss and diabetes prevention. A prospective cohort study of 135,000 participants also showed that nutritive carbohydrate intake was associated with increased mortality rates [55]. It is important to note, of course, that many of the potential mechanisms of low-carbohydrate diets require further research and that strict low-carbohydrate diets (20-50 g per day) may also have some risks and adverse effects and should therefore be considered with caution [39]. ...
... On the one hand, a large amount of basic data that substantiate previous conclusions have been obtained. For example, mtDNA mutational hotspots, which are closely related to disease and ageing, have been extensively examined (Hirose et al. 2016;Niemann et al. 2017;Spangenberg et al. 2019), mitochondrial protein maps have been accurately drawn (Calvo et al. 2016;Sickmann et al. 2003), and the localizations of many important signalling molecules in mitochondria have been identified (Calvo et al. 2016). On the other hand, new findings about mitochondria are constantly being reported. ...
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