Michael D. Kulis’s research while affiliated with Microbiome Core Facility USA and other places

... We plan on using the mature (6-week-old) CC027/CeniUnc strain of Mus musculus mice that have been sensitized to peanuts by genetically modifying them, which increases their gut permeability and decreases immunoglobulin A (IgA) production, eliciting peanut sensitivity. [16]. Increasing gut permeability contributes to causing peanut sensitivity in the mice by allowing a greater number of allergens across the intestinal lumen and increasing interactions with the immune system [17]. ...

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Fungal Proteases in the Preventative Treatment of Peanut Allergies: A Research Protocol

... The landmark Food and Drug Administration (FDA) approval of Palforzia, a powdered peanut allergen, occurred in 2020 as the first allergen medication approved by the FDA. Omalizumab, an anti-immunoglobulin E (IgE) therapy, has also shown potential in managing multiple FAs, as demonstrated by the OUtMATCH (omalizumab as monotherapy and as adjunct therapy in children and adults) study [5]. However, cost, availability and injections may inhibit widespread usage, particularly in at-risk populations in the developing world. ...

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Food allergy: emerging therapies in the twenty-first century

... Another area of research is the application for omalizumab beyond its current indications. A promising recent trial has demonstrated utility for omalizumab in treating food allergies, specifically in preventing allergic reactions to accidentally exposed food allergens, but future studies will need to validate those findings [58][59][60]. Evidence is growing that IgE could be involved in autoimmune diseases such as in bullous pemphigoid (BP) or systemic lupus erythematosus (SLE), which has sparked the evaluation of omalizumab in those conditions [61][62][63]. ...

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A Comparison of Natural and Therapeutic Anti-IgE Antibodies

... In addition, the identification of linear peptides plays a role in the follow-up of milk immunotherapy in allergic patients, as previously demonstrated by our group [19]. The usefulness of peptides in the follow-up of oral immunotherapy with other foods has also been found for eggs and peanut [28,29]. Knowledge of B-reactive epitopes throughout the patients' natural history would also allow for the design of more selective vaccines. ...

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Predicting Tolerance to Cow’s Milk Allergy in Children Using IgE and IgG4 Peptide Binding Profiles

... [154,155] Recently, results of phase 2 trials of an S1P receptor modulator and of an immunomodulatory chaperone protein were promising, and these agents may be studied in the figure. [156,157] Summary of some of the expermintal therapies used for EoE is provided in Table 2. ...

Reference:

Eosinophilic esophagitis: Current concepts in diagnosis and management

... Desensitization and remission was observed in 1-to 4-year-old children, with improved outcomes seen with younger age at initiation. Further, changes in SPT, IgG 4 , and IgG 4 /IgE ratio were seen in peanut SLIT but not placebo participants (172). In an open-label study of the efficacy, safety, and durability of peanut SLIT in peanut-allergic children, the mean successfully consumed dose increased from 48 to 2723 mg of peanut protein after 48 months of treatment with 70% achieving clinically significant desensitization (> 800 mg) and 36% achieving full desensitization (5000 mg) (173). ...

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Scientific developments in understanding food allergy prevention, diagnosis, and treatment

... In addition, the role of Tfh cells in air pollutants exacerbating asthma has been highlighted. The air pollutant-diesel exhaust particles exacerbating asthma were dependent upon the differentiation of Tfh cells, which was related to the IL-1 signaling pathway on the Tfh cells (Immormino et al., 2023). Consequently, it is also important to investigate how orally exposed risk factors and constituents elevate IgE levels by influencing Tfh cells, which may be regarded as target cells. ...

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The potential of orally exposed risk factors and constituents aggravating food allergy: Possible mechanism and target cells

... In 2020, Peterson et al. found that patients with active EoE had increased food-specific IgA and IgG4 compared to controls from esophageal brushing statistically significant for positive wheat or dairy triggers [15]. However, further study could not replicate such results with food-specific IgA from esophageal biopsies in active EoE patients [16]. ...

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Dietary Therapy in Eosinophilic Esophagitis

... Smeekens et al., revealed that the vaccination with shellfish allergen DNA using a PowderJect XR DNA vaccine delivery system increased shrimp-specific IgG and C3H/HeJ is the best among three strains of mice (70). Kubo et al. reported that a single DNA plasmid vaccine constructed from Litopenaeus vannamei (Lit)-lysosomalassociated membrane protein (lit-LAMP-DNA-vaccine) promoted Th1 responses, thwarting anaphylaxis in shrimp-sensitized mice, suggested the lit-LAMP-DNA-vaccine can be developed to prevent or treat shrimp allergy (69)(70)(71). ...

Reference:

Diagnosis and management of shrimp allergy

... The study by Smeekens and colleagues further demonstrated that airway sensitization can lead to the failure of oral tolerance [280]. C57BL/6 J mice exposed to peanut with adjuvant (LPS) through the airway just once, followed by high-dose oral peanut feeding, developed peanut-specific IgE and IgG1 and exhibited allergic responses upon peanut challenge. ...

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Allergens in Atopic Dermatitis