Michael A. White's research while affiliated with The University of Sheffield and other places

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Publications (6)

Supplementary Material 2
Data
  • Oct 2017
Table S1. Microarray data and RT‐PCR comparing the 150% and 40% aerobiosis steady states and at time points during the transition from 150% to 40% aerobiosis. In the ‘All significant (p < 0.05) genes’ tab, the fold‐changes of genes which showed a greater than twofold change in expression with a significance of p < 0.05 at any one of the time points...
Supplementary Material 1
Data
  • Oct 2017
Fig. S1. Physiological data for the transition experiment from 150% to 40% aerobiosis. At time zero, the input gas composition was changed from 7.5% v/v oxygen (150% aerobiosis) to 1.88% oxygen (40% aerobiosis). A. Change in optical density at 600 nm. B. Corresponding increase in the specific acetate excretion rate. C. Dry weight at the high and lo...
Supplementary Material 3
Data
  • Oct 2017
Table S2. Label‐free LC‐MS/MS analysis of proteins at 40% and 150% aerobiosis. Samples from three independent steady‐states at 1.88% v/v oxygen or 40% aerobiosis (LF1‐3) and three at 7.5% v/v oxygen or 150% aerobiosis (LF‐4‐6) were analysed by LC‐MS/MS as described in Experimental Procedures. In the tables shown, A,B,C are gel lane replicates of ea...
Supplementary Material 4
Data
  • Oct 2017
Table S3. 2D‐gel analysis of proteins from cells grown at all steady‐states from 25% to 345% aerobiosis. In the ‘All steady‐state raw data’ tab, the normalised spot volumes from image analysis for a given protein are shown for multiple gels run with a minimum of 1 steady‐state per oxygen input condition (50% and 75% aerobiosis) or with two or more...
Fig. 1. Experimental design (A) and physiological parameters of C....
Fig. 3. Methylmenaquinol:fumarate reductase (Mfr) gene expression,...
Fig. 4. Oxygen-dependent changes in gene expression and protein...
Fig. 5. Responses of central catabolic enzymes and associated solute...
+3 Fig. 6. Proline transporter (PutP), proline utilization A (PutA) gene...
Transcriptome and proteome dynamics in chemostat culture reveal how Campylobacter jejuni modulates metabolism, stress responses and virulence factors upon changes in oxygen availability: Global oxygen responses of C. jejuni
Article
Full-text available
  • Sep 2017
Campylobacter jejuni, the most frequent cause of food-borne bacterial gastroenteritis worldwide, is a microaerophile that has to survive high environmental oxygen tensions, adapt to oxygen limitation in the intestine and resist host oxidative attack. Here, oxygen-dependent changes in C. jejuni physiology were studied at constant growth rate using c...
Fig. 1. Structural modelling and sequence comparisons of C. jejuni CA...
Fig. 2. Gene organization and expression analysis of cj0229 and canB....
Fig. 3. Comparative microaerobic growth of the C. jejuni wild-type...
Fig. 5. Overexpression and purification of CanB. A. 12% SDS-PAGE of...
+2 Fig. 6. CO2 hydration and bicarbonate dehydration activity of CanB. In...
Major contribution of the type II beta carbonic anhydrase CanB (Cj0237) to the capnophilic growth phenotype of Campylobacter jejuni
Article
Full-text available
  • Oct 2015
Campylobacter jejuni, the leading cause of human bacterial gastroenteritis, requires low environmental oxygen and high carbon dioxide for optimum growth, but the molecular basis for the carbon dioxide requirement is unclear. One factor may be inefficient conversion of gaseous CO2 to bicarbonate, the required substrate of various carboxylases. Two p...

Citations

... In C. jejuni, mdaB was reported to have a role in oxidative stress; yet the specific role for its product has been elusive (3,46,47). We present evidence to show that both mdaB and its regulator RrpA respond to quinones. ...
Reference: MdaB and NfrA, Two Novel Reductases Important in the Survival and Persistence of the Major Enteropathogen Campylobacter jejuni
Transcriptome and proteome dynamics in chemostat culture reveal how Campylobacter jejuni modulates metabolism, stress responses and virulence factors upon changes in oxygen availability: Global oxygen responses of C. jejuni
Citing article
  • Sep 2017
... Among the ASVs that were more abundant in the high-treatment samples at later time points were members of the order Campylobacterales. Most species of this order are capnophiles that thrive in high-CO 2 environments (Al-Haideri et al. 2016;Waite et al. 2017). ASVs in the genus Vibrio initially had low abundances in the high-CO 2 treatment, but at later time points they were significantly more abundant in the high-CO 2 treatment than in the control. ...
Reference: Ocean acidification alters the diversity and structure of oyster associated microbial communities
Major contribution of the type II beta carbonic anhydrase CanB (Cj0237) to the capnophilic growth phenotype of Campylobacter jejuni
Citing article
  • Oct 2015