Meng Niu's research while affiliated with First Affiliated Hospital of China Medical University and other places

Publications (50)

Article
Full-text available
Deep vein thrombosis is a common clinical peripheral vascular disease that occurs frequently in orthopaedic patients and may lead to pulmonary embolism (PE) if the thrombus is dislodged. pulmonary embolism can be prevented by placing an inferior vena cava filter (IVCF) to intercept the dislodged thrombus. Thus, IVCFs play an important role in ortho...
Article
Thermotherapy can directly kill tumor cells while accompanied by immune-enhancing effects. However, this immune-enhancing effect suffers from insufficient expression of immune response factors (e.g., heat shock protein 70, HSP70), resulting in no patient benefiting due to the recurrence of tumor cells after thermotherapy. Herein, we explore the nan...
Article
Full-text available
Background Portal hypertension monitoring is important throughout the natural course of cirrhosis. Hepatic venous pressure gradient (HVPG), regarded as the golden standard, is limited by invasiveness and technical difficulties. Portal hypertension is increasingly being assessed non-invasively, and hematological indices, imaging data, and statistica...
Article
Microwave hyperthermia is an emerging minimally invasive therapy in which thermal damage and apoptosis of tumor cells are induced by local heating of tissues with microwave radiation. Recently, microwave hyperthermia has been widely used in clinical practice; however, uneven aggregation and dispersion of malignant tumors after microwave hyperthermi...
Preprint
Backgrounds: Reversing the immunosuppressive microenvironment (TME) in the tumor is widely deemed to be an effective strategy to improve immune therapy. In particular, the redox balance in TME needs to be well controlled due to its critical role in mediating the functions of various cells, including cancer cells and immune-suppressive cells. Here,...
Article
Metal-organic frameworks (MOFs) have been developed for tumor therapy in recent years, but so far there have been very few reports about the use of single metallic manganese (Mn) MOF in tumor therapy due to limited types of organic ligands. Expending on advantages of Mn-based nanoplatform, a novel magnetic resonance imaging (MRI)-monitored, microwa...
Article
Microwave (MW) hyperthermia is one of the safest and most efficient minimally invasive tumor treatment methods, it is restricted by the bottlenecks of the heat sink effect and ineffective immune activation. Herein, a multifunctional nano platform with the load of nano immune modulator bimetallic metal-organic framework (BM), tumor vessel destructiv...
Article
The presence of high content glutathione (GSH) provides an effective "protective shield" for tumor cells, which undoubtedly is a huge impediment to reactive oxygen species (ROS)-based treatment. Fortunately, divalent copper (Cu2+) can not only consume GSH, destroying the protection mechanism of GSH, but also can be reduced to Cu+ with excellent Fen...
Article
Hepatocellular carcinoma (HCC) remains the most common malignancy to threaten public health globally. With advances in artificial intelligence techniques, radiomics for HCC management provides a novel perspective to solve unmet needs in clinical settings, and reveals pixel-level radiological information for medical imaging big data, correlating the...
Article
Microwave thermal therapy (MWTT) shows great prospect in cancer treatments due to its non-invasive or minimally invasive nature and deep penetration through the tissue. However, incomplete ablation and elevated expression of many pro-tumor angiogenesis after MWTT (e.g., vascular endothelial growth factor, VEGF) induced tumor recurrence still remain...
Conference Paper
This work aimed to develop a noninvasive and reliable computed tomography (CT)-based imaging biomarker to predict early recurrence (ER) of intrahepatic cholangiocarcinoma (ICC) via radiomics analysis. In this retrospective study, a total of 177 ICC patients were enrolled from three independent hospitals. Radiomic features were extracted on CT image...
Article
The microwave dynamic therapy (MDT) mediated by cytotoxic reactive oxygen species (ROS) is a promising anticancer therapeutic method. However, the therapeutic efficiency of MDT is restricted by several limitations including insufficient ROS generation, strong proangiogenic response, and low tumor-targeting efficiency. Herein, we find that Cu-based...
Article
Studies have shown that a higher GSH level is related to more drug-resistant and invasiveness of a tumor. However, it is a great challenge to accurately imaging the GSH level in vivo , for its imaging intensity will interfered by different accumulation of probes in the tumor. Thus, we hypothesized ratiometric photoacoustic imaging that can be used...
Article
Objective: In a few patients with mild COVID-19, there is a possibility of the infection becoming severe or critical in the future. This work aims to identify high-risk patients who have a high probability of changing from mild to critical COVID-19 (only account for 5% of cases). Methods: Using traditional convolutional neural networks for class...
Article
Full-text available
Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). Preknowledge of MVI would assist tailored surgery planning in HCC management. In this multicenter study, we aimed to explore the validity of deep learning (DL) in MVI prediction using two imaging modalities—contrast-enhanced comput...
Article
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Locoregional therapies (LRTs) of hepatocellular carcinoma (HCC) represented by ablation and TACE has become the main means for the clinical treatment of unresectable HCC. Among these, TACE is used throughout the stage Ib to IIIb of HCC treatment. In recent years, immunotherapy led by immune checkpoint inhibitors has become a hot direction in clinic...
Article
In recent years, the growing studies focused on the immunotherapy of hepatocellular carcinoma and proved the preclinical and clinical promises of host antitumor immune response. However, there were still various obstacles in meeting satisfactory clinic need, such as low response rate, primary resistance and secondary resistance to immunotherapy. Ta...
Article
Vessel embolization is recommended as the first line treatment for unresectable hepatocellular carcinoma (HCC). However, owing to the imprecise vessel embolization and heterogeneous response performance among patients, its survival benefits are often compromised. Herein, we reported an innovative strategy to extensively embolize the tumor by trigge...
Article
Since its outbreak in December 2019, the persistent coronavirus disease (COVID-19) became a global health emergency. It is imperative to develop a prognostic tool to identify high-risk patients and assist in the formulation of treatment plans. We retrospectively collected 366 severe or critical COVID-19 patients from four centers, including 70 pati...
Article
The cover image is based on the Review Article Radiomics in Liver Diseases: Current Progress and Future Opportunities by Jie Tian, Hanyu Jiang, Jing Wei Wei et al., https://doi.org/10.1111/liv.14555.
Article
Full-text available
PurposeTo develop and validate a novel method based on radiomics for the preoperative differentiation of benign and malignant gallbladder polypoid lesions (PLG).Patients and methodsA total of 145 patients with pathological proven gallbladder polypoid lesions ≥ 1 cm were included in this retrospective study. All the patients underwent abdominal cont...
Article
Full-text available
Liver diseases, a wide spectrum of pathologies from inflammation to neoplasm, have become an increasingly significant health problem worldwide. Noninvasive imaging plays a critical role in the clinical workflow of liver diseases, but conventional imaging assessment may provide limited information. Accurate detection, characterization and monitoring...
Article
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Coronavirus disease 2019 (COVID-19) has spread globally, and medical resources become insufficient in many regions. Fast diagnosis of COVID-19, and finding high-risk patients with worse prognosis for early prevention and medical resources optimisation is important. Here, we proposed a fully automatic deep learning system for COVID-19 diagnostic and...
Article
Full-text available
Purpose To develop a deep learning-based method to assist radiologists to fast and accurately identify patients with COVID-19 by CT images. Methods We retrospectively collected chest CT images of 495 patients from three hospitals in China. 495 datasets were randomly divided into 395 cases (80%, 294 of COVID-19, 101 of other pneumonia) of the train...
Preprint
Full-text available
Coronavirus disease 2019 (COVID-19) has spread globally, and medical resources become insufficient in many regions. Fast diagnosis of COVID-19, and finding high-risk patients with worse prognosis for early prevention and medical resources optimization is important. Here, we proposed a fully automatic deep learning system for COVID-19 diagnostic and...
Article
Full-text available
Hypoxia is a hallmark of malignant tumors and often correlates with increasing tumor aggressiveness and poor treatment outcomes. Therefore, early diagnosis and effective killing of hypoxic tumor cells are crucial for successful tumor control. There has been a surge of interdisciplinary research aimed at developing functional molecules and nanomater...
Article
Full-text available
Objectives To establish a pre-therapy prognostic index model (PIM) of the first-line chemotherapy aiming to achieve accurate prediction of time to progression (TTP) and overall survival among the patients diagnosed with locally advanced (stage III) or distant metastasis (stage IV) lung squamous cell carcinoma (LSCC). Methods Ninety-six LSCC patien...
Article
There are acknowledged risks of metastasis of cancer cells and obstructing cancer treatment from hypoxia. In this work, we design a multifunctional nanocomposite for treating hypoxia based on the oxygen release capability of CuO triggered by microwave (MW). Core-shell CuO@ZrO2 nanocomposites are prepared by confining CuO nanoparticles within the ca...
Article
Background: Several studies have reported that hepatitis B virus (HBV) infection affects the risk of coronary heart disease. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to better understand it. Methods: Relevant studies published before October 2017 were identified by searching PubMed, EMBA...
Article
Background: With the development of nanomaterials, nanoparticle-based therapeutics have found increasing application in various fields, including clinical and basic medicine. Real-time monitoring of nanoparticle-based therapeutics is considered critical to both pharmacology and pharmacokinetics. Methods: In this review, we discuss the different...
Article
Zeolitic imidazolate frameworks (ZIFs) have attracted great interest as pH-sensitive drug carrier because of high drug loading and intrinsic biodegradability. In this work, a biocompatible NIR and pH-responsive drug delivery nanoplatform based on ZIFs (PDA-PCM@ZIF-8/DOX) is synthesized for in vivo cancer therapy. The biocompatibility of ZIFs is gre...
Article
Background: With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays. Methods: We performed a PubMed/MEDLINE search for all publications in the English language...
Article
Combined thermo-chemotherapy displays outstandingly synergically therapeutic efficacy compare with stand-alone thermotherapy and chemotherapy. This paper developed a smart tri-stimuli responsive drug delivery system X@BB-ZrO2 NPs (X represents the loaded IL, DOX, keratin and tetradecanol) based on novel ball-in-ball structure ZrO2 nanoparticles (BB...
Article
The use of nanomaterials as drug delivery systems shows good effects in treating tumors. However, the effective dose of drugs targeted to tumor tissues is very low because of the effect of the reticuloendothelial system (RES) in removing such foreign substances. In order to eliminate the RES effect, we developed mPEG-PLGA@ZrO2@(DOX + ILS) (mPEG-PLG...
Article
Background A variety of targeted drug therapies in clinical trials have been proven to be effective for the treatment of hepatocellular carcinoma (HCC). Our study aims to compare the short-term and long-term efficacies of different targeted drugs in advanced hepatocellular carcinoma (AHCC) treatment using a network meta-analysis approach. Methods...
Article
Full-text available
Herein, we develop a novel integrated strategy for the preparation of theranostic chitosan microcapsules by encapsulating ion liquids (ILs) and Fe3O4 nanoparticles. The as-prepared chitosan/Fe3O4@IL microcapsules exhibit not only significant heating efficacy in vitro under microwave (MW) irradiation but also obvious enhancement of T2-weighted magne...
Article
Although mesoporous silica nanoparticles (MSNs) are widely used in food products, cosmetics and nanomedicines as vector for drug delivery, data on their potential genotoxocity are limited. The aim of this study was to investigate the cytotoxic and genotoxic potentials of MSNs of different shapes, and to establish a high-throughput screening method...
Article
Combining photothermal therapy (PTT) with clinical technology to kill cancer via overcoming the low tumor targeting and poor therapy efficiency has great potential in basic and clinical researches. A brand-new MoS2 nanostructure is designed and fabricated, i.e., layered MoS2 hollow spheres (LMHSs) with strong absorption in near-infrared region (NIR...
Article
Full-text available
Several studies have reported that hepatitis B virus (HBV) infection may decrease the risk of stroke. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to investigate the relationship between hepatitis B virus (HBV) infection and the risk of stroke. Relevant studies published before May 2017 were id...
Article
Full-text available
Hepatitis B and hepatitis C are leading causes of chronic liver disease, particularly cirrhosis. Recently, several studies have observed that statins have an inverse relationship with cirrhosis in hepatitis B or C patients. However, no published meta-analysis studied the protective effect of statins on cirrhosis. Thus, we conducted a systematic rev...
Article
Full-text available
This study develops a simple hollow ZrO2 nanostructure as carriers to encapsulate ionic liquid (IL), which integrates CT imaging function of ZrO2 shell and microwave susceptible function of IL core. The simple nanostructure can be used as a multifunctional theranostic agent via combining diagnostic and therapeutic modalities into one 'package'. Bas...

Citations

... Recently, gallium-based liquid metal alloy (EGaIn) was combined with Ag (noble metal) in core-shell hybrid nanostructure (as EGaIn@Ag@Ag 2 S ) and was observed to have superior sensing properties due to Ag nanoflakes [15]. In another such case, Yu et al. successfully synthesized copper-coated GaIn nanoparticle in core-shell structure for tumor treatment under chemodynamic therapy [16]. Hence, liquid metals combined with noble metals are entering into the fields of biosensing and microwave thermal therapy [17][18][19][20][21]. Previously, LSPRs of Ga NPs have shown tremendous applications due to its UV absorption which expands up to visible region based on the scaling of NP size, shape, and surrounding environment [22][23][24]. ...
... Heat could damage normal cells, making complete tumor ablation impossible [161]. Similarly, other methods, such as PDT, immunotherapy, microwave-mediated therapy, etc., also have obstacles to be solved [162][163][164][165]. Researchers have been dealing with the limitations and in 2019, Chen et al. devised COF possessing a dual-modal function [166]. ...
... To date, in several studies have been assessed the role of radiomics or radiogenomics in ICC [72,79,. The area of main interest has been the evaluation of recurrence after surgical resection [72,79,[180][181][182][183][184][185][186][187]. Chu et al. [79] evaluated 203 ICCs, that were allocated with a ratio of 7:3 into the training cohort and the validation cohort. ...
... [8][9][10] Moreover, insufficient thermal ablation could induce angiogenesis and aggravate hypoxia in tumors, resulting in increased local recurrence and distance metastasis. Accumulating evidence has shown that high expressions of VEGF and CD31 and elevation of HIFs were observed aer insufficient MW ablation [11][12][13] and insufficient radiofrequency ablation (RFA). [14][15][16][17][18][19] Inhibition of tumor recurrence following MW ablation remains a challenge in clinic, as evidenced by three-year clinical postablation recurrence data, 20 which threatened the prognosis and lifetime of patients with cancer. ...
... Numerous NP-based techniques require tumor infiltration by NPs. The clinical significance of EPR stays disputable, and there is proof that a solitary little part of directed NPs conveying ordinary chemotherapeutic molecules gets to the tumor tissues, neglecting to accomplish a significant restorative record in clinical preliminaries [116]. Irrespective of the fact that NPs have flexible properties which can be altered based on the biological interaction for effective therapeutic bonding. ...
... Apatinib was approved for increased use in China for the treatment of patients with advanced HCC who had previously failed or were intolerant to at least one first-line systemic therapy in December 2020. TACE in combination with Apatinib was superior to TACE alone in the long-term treatment of advanced HCC (12,13), while apatinib could be used as second-line treatment in advanced HCC therapy. However, the most suitable agent combined with apatinib in TACE treatment needs to be identified. ...
... Deep learning has also achieved good results in the prediction of microvascular invasion in hepatocellular carcinoma. Jingwei Wei [18] et al. retrospectively studied two data types of multi-center Contrast-enhanced computed tomography(CE-CT) and Ethoxybenzyl-MRI(EOB-MRI) to build deep learning models, and visualize the high-risk areas of MVI by attention maps. The results show that the deep learning model based on EOB-MRI is more effective than deep learning models based on CE-CT, and both models can stratify high-risk and low-risk groups for recurrence-free survival and overall survival with good results in HCC patients. ...
... MnO 2 was reduced to Mn 2+ by high intracellular GSH, and self-assembled with verteporfin (BPD) to produce MnO 2 /BPD. This process also generated O 2 to enhance the effects of photodynamic therapy (PDT) and deplete GSH, which prolonging the life of the ROS and amplified ROS damage [160]. ...
... As is well known, hundreds of millions of people around the world have been infected by COVID-19, and several million have died [8][9][10][11][12][13][14]. Therefore, in order to reduce the transmission of COVID-19, governments have taken measures that have proven to be very effective [15,16]. ...
... To this end, two groups of AI-based techniques can be mentioned: radiomics, which relies on ML, and DL systems (based on neural networks) (6). Radiomics has emerged as a high-throughput computing technique that enables extraction of large amounts of quantitative features from medical imaging, mainly computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) (50). This vast amount of variables can be correlated with specific clinical outcomes of interest, providing far more information than those detectable by an experienced physician (51). ...