March 2025
ACS Applied Nano Materials
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Publications (5)
February 2025
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3 Reads
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1 Citation
ACS Applied Nano Materials
April 2022
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11 Reads
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6 Citations
Journal of Materials Chemistry B
Cancer is one of the major diseases that pose a threat to human health and life, especially because it is difficult to diagnose and cure, and recurs easily. In recent years, the development of nanotechnology has provided researchers with new tools for cancer treatment. In particular, nanoprobes that facilitate integrated diagnosis and treatment, high-resolution imaging, and accurate tumor targeting provide new avenues for the early detection and treatment of cancer. This review focuses on the preparations and applications of two kinds of "smart" multifunctional nanoprobes: "Off-On" nanoprobes and "Charge-Reversal" nanoprobes. This review also briefly discusses their mechanisms of action, as they could provide new ideas for the further development of this field.
April 2022
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63 Reads
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7 Citations
Journal of Materials Science
Bacterial infections are closely associated with tumor growth and metastasis. Bacteriostasis can not only inhibit the growth and metastasis of tumors during their early diagnosis and treatment but also prevent bacterial infections after recovery. In this study, we synthesized Ag@GQD which consisted of nitrogen-doped graphene quantum dots (N-GQD) wrapped around Ag NPs through the photocatalytic reduction method. Multifunctional nanoprobes (Ag/DOX@GQD) were obtained by doxorubicin (DOX) loading. Ag@GQD exhibited high stability, low cytotoxicity, and good photoacoustic imaging performance. The effective photothermal performance of Ag@GQD enabled us to achieve the controlled release of DOX from probes using near-infrared light and pH response during the treatment of tumors using chemo-photothermal combination therapy. Results from cell-based experiments revealed that combination therapy was superior to single-drug therapy. Besides, Ag@GQD could effectively kill Staphylococcus aureus and Escherichia coli and can be expected to inhibit the growth and metastasis of tumors caused by bacteria and in reducing bacterial infections after recovery.
![Figure 1. Schematic illustration of the preparation of polymeric-inorganic hybrid nanocomposites and the bispecific antibody-based immunotherapy. Adapted with permission from [50], copyright 2019 Elsevier Science Inc. BsAb: bispecific antibody; MC.DNA: minicircle DNA; PIHN: polymeric-inorganic hybrid nanocomposite; PEI: polyethyleneimine; SPIO: superparamagnetic Fe3O4.](https://www.researchgate.net/publication/352080136/figure/fig1/AS:1030460998156289@1622692455162/Schematic-illustration-of-the-preparation-of-polymeric-inorganic-hybrid-nanocomposites_Q320.jpg)
![Figure 2. In vivo two-plex NIR-IIb molecular imaging of immune responses using ErNPs-aPDL1 and PbS-aCD8 at the same ~1,600 nm emission range. A. Schematic illustration outlining the experimental setup (left) to distinguish the PbS QD emission channel (right) by using an 808 nm CW laser. B. Schematic of the experimental setup (left) to differentiate the long-lived ErNP luminescence (right) from short-lived PbS QD fluorescence by using a 980 nm laser pulse. The insets show corresponding cross-sectional intensity profiles (blue color). C. Lifetime decays of ErNPs-aPDL1 and Pbs-aCD8 in 1 × PBS solution. D. Absorption spectra of ErNPs-aPDL1 and PbS-aCD8. E. Emission spectra of ErNPs-aPDL1 and PbS-aCD8. The detection region is 1,500 -1,700 nm. F. Two-plex molecular imaging (upper right) of a CT-26 tumor mouse at 24 h post intravenous injection of mixed ErNPs-aPDL1 (green color, upper left) and PbS-aCD8 (red color, lower left). Scale bar, 5 mm. The zoomed-in high-magnification two-plex image (lower right) outlines the CT-26 tumor with micrometer image resolution (scale bar, 500 μm). G. Corresponding two-plex rotation (−90º to +90º) imaging showing the in vivo bio-distribution of ErNPs-aPDL1 (green color) and PbS-aCD8 (red color) in the whole body. Scale bar, 5 mm. Similar results for n > 3 independent experiments. OD, optical density. Adapted with permission from [43], copyright 2019 Nature Publishing Group. ErNPs: cubic-phase (α-phase) erbium-based rare-earth nanoparticles; ErNPs-aPDL1: anti-PD-L1 mAb (atezolizumab) conjugated with ErNPS; PbS QDs: sulfide quantum dots; Pbs-aCD8: anti-CD8α mAb (clone 2.43) conjugated with Pbs QDs.](https://www.researchgate.net/publication/352080136/figure/fig2/AS:1030460998172672@1622692455213/n-vivo-two-plex-NIR-IIb-molecular-imaging-of-immune-responses-using-ErNPs-aPDL1-and_Q320.jpg)
![Figure 3. In vivo NIR and MRI tracking of the migration of AB-BCA-treated BMDCs to LNs in mice. BMDCs treated with or without AB-BCA were subcutaneously injected in both hind footpads at a density of 5 × 10 6 cells/mouse. A. NIR fluorescence images of the whole body at 24 h after injection. B. NIR fluorescence images of the magnified thigh at 24 h after injection. C. NIR fluorescence images of the magnified thigh at 48 h after injection. D. MR images at 24 h after injection. Arrows indicated the LNs. Adapted with permission from [45], copyright 2016 Amer Chemical Soc.](https://www.researchgate.net/publication/352080136/figure/fig3/AS:1030460998160384@1622692455298/n-vivo-NIR-and-MRI-tracking-of-the-migration-of-AB-BCA-treated-BMDCs-to-LNs-in-mice_Q320.jpg){kind=tracking}
![Figure 4. Schematic illustration of NIR light-inducible LINC for self-amplified drug delivery and combination immunotherapy. Arrows indicated the LNs. Adapted with permission from [82], copyright 2019 Wiley-V C H Verlag Gmbh. CTLs: cytotoxic T lymphocytes; IDO-1: indoleamine 2-dioxygenase 3-dioxygenase 1; ICD: immunogenic cell death; LINC: light-induced immunotherapy nano-drug; OXA: oxaliplatin; PN: indoleamine 2-dioxygenase 3-dioxygenase 1 (IDO-1) inhibitor NLG919; GHS: glutathione; PPa: photosensitizer pheophorbide A.](https://www.researchgate.net/publication/352080136/figure/fig4/AS:1030460998160385@1622692455345/Schematic-illustration-of-NIR-light-inducible-LINC-for-self-amplified-drug-delivery-and_Q320.jpg)
![Figure 5. In vivo PAI-guided monitoring of BLZ-945 and drug release. A. PA images of MCF-7 tumor-bearing Balb/c nude mice treated with AuNNP@SN38/BLZ-945 Ve at different time points post-injection. B. PA images of MCF-7 tumor-bearing Balb/c nude mice treated with AuNNP Ve at different time points post-injection. C. The PA spectra of the tumors treated with AuNNP@SN38/BLZ-945 Ve at different time points in the photograph of tumor bearing mice. D. The PA spectra of the tumors treated with AuNNP Ve at different time points in the photograph of tumor bearing mice. Adapted with permission from [90], copyright 2020 Amer Chemical Soc.](https://www.researchgate.net/publication/352080136/figure/fig5/AS:1030460998160386@1622692455376/n-vivo-PAI-guided-monitoring-of-BLZ-945-and-drug-release-A-PA-images-of-MCF-7_Q320.jpg)
May 2021
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37 Reads
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27 Citations
Theranostics
Immunotherapy is an effective tumor treatment strategy that has several advantages over conventional methods such as surgery, radiotherapy and chemotherapy. Studies show that multifunctional nanoprobes can achieve multi-mode image-guided multiple tumor treatment modes. The tumor cells killed by chemotherapies or phototherapies release antigens that trigger an immune response and augment the effects of tumor immunotherapy. Thus, combining immunotherapy and multifunctional nanoprobes can achieve early cancer diagnosis and treatment. In this review, we have summarized the current research on the applications of multifunctional nanoprobes in image-guided immunotherapy. In addition, image-guided synergistic chemotherapy/photothermal therapy/photodynamic therapy and immunotherapy have also been discussed. Furthermore, the application potential and clinical prospects of multifunctional nanoprobes in combination with immunotherapy have been assessed.
Citations (3)
... Smart nanoparticles exhibit multifunctionality in most cancer remedies by integrating diagnosis and treatment, enhancing imaging resolution, and allowing precise tumor concentration. 64 These nanoparticles, including multifunctional nanoprobes, provide a sophisticated system with optimized amendment websites and green feature integration, making them powerful tools for competitive tumor targeting. 65 One of the important aspects of multifunctionality in smart nanoparticles is their potential for use in goal-specific cells or tissues. ...
- Citing Article
April 2022
Journal of Materials Chemistry B
... He [40] prepared EPP-Agn-NPs with good biocompatibility and bacterial inhibition up to 68 % using a green synthesis method. The Ag@GQD probe synthesized by Guan [41] was effective in inhibiting the growth of E. coli and Staphylococcus aureus. The bactericidal mechanism of transition metal nanoparticles varies. ...
- Citing Article
- Publisher preview available
April 2022
Journal of Materials Science
... These nanoparticles (NPs) can be converted into microbubbles (MBs), which improve ultrasonography imaging quality by inducing a phase change through the application of heat or ultrasound irradiation. This noninvasive approach enables the visual diagnosis of tumor biological behaviors at the cellular and subcellular levels [8][9][10]. Upon triggering a phase change in the NPs, the encapsulated perfluoropentane (PFP) is gasified to release O 2 , leading to an increase in reactive oxygen species (ROS) production in tumor cells [11]. ...
- Citing Article
- Full-text available
May 2021
Theranostics