Meltem Muftuoglu’s research while affiliated with Acıbadem University and other places

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Publications (1)


Designed primers for VDR and GC genes
ACTB gene was used for internal control.
Demographic parameters in subjects
Baseline biochemical characteristics of subjects
Baseline levels of variables in vitamin D supplementation and placebo groups
Change in variables after treatment in vitamin D supplementation and placebo groups

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Leukocyte telomere length as a compensatory mechanism in vitamin D metabolism
  • Article
  • Full-text available

February 2022

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54 Reads

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4 Citations

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Meltem Muftuoglu

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Vitamin D deficiency is common among postmenopausal women. Telomere length can be a potential protective mechanism for age-related diseases. The objective of our study is to examine the association of vitamin D supplementation on leukocyte telomere length (LTL) in healthy postmenopausal women with vitamin D deficiency. The study was designed as a placebo-controlled study to investigate the short-term effects of vitamin D supplementation and seasonal changes on vitamin D related parameters, including 25(OH)D, 1,25(OH)2D parathormone (PTH), Vitamin D binding protein (VDBP), vitamin D receptor (VDR), and telomere length in a cohort of postmenopausal women (n = 102). The group was divided as supplementation (n = 52) and placebo groups (n = 50). All parameters were measured before and after treatment. Serum VDBP levels were measured by ELISA method and VDR, GC (VDBP) gene expressions and relative telomere lengths were measured in peripheral blood mononuclear cells (PBMC) using a quantitative real-time PCR method. The results demonstrate that baseline levels were similar between the groups. After vitamin D supplementation 25(OH)D, 1,25(OH)2D, PTH and VDBP levels were changed significantly compared to the placebo group. At the end of the study period, LTL levels were significantly increased in both groups and this change was more prominent in placebo group. The change in GC expression was significant between treatment and placebo groups but VDR expression remained unchanged. Even though the study was designed to solely assess the effects of vitamin D supplementation, LTL was significantly increased in the whole study group in summer months suggesting that LTL levels are affected by sun exposure and seasonal changes rather than supplementation. The study displayed the short-term effect of Vitamin D supplementation on vitamin D, PTH levels, LTL and vitamin D associated gene expressions. The relation between Vitamin D and LTL is not linear and could be confounded by several factors such as the population differences, regional and seasonal changes in sun exposure.

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Citations (1)


... One randomised controlled trial (RCT) found no beneficial effect of vitamin D supplementation on telomere length; however, this study included only 102 postmenopausal women with vitamin D deficiency (<50 nmol/L) and treatment duration was short (50,000 international units/week for 8 weeks) (24). Another RCT, performed in 37 overweight African American adults (aged 19-50 years), found that supplementation with 60,000 international units (IU) of vitamin D per month for 16 weeks resulted in increased telomerase activity in peripheral blood mononuclear cells (PBMCs) (25). ...

Reference:

Effects of Vitamin D Supplementation on Telomere Length: An Analysis of Data from the Randomised Controlled D-Health Trial
Leukocyte telomere length as a compensatory mechanism in vitamin D metabolism