Melissa C. Selinger's research while affiliated with Palm Beach Atlantic University and other places

Publications (4)

Article
Full-text available
The so-called "club drug" Foxy or Methoxy Foxy (5-Methoxy-N,N-di(iso)propyltryptamine hydrochloride; 5-MeO-DIPT) is a newer drug of abuse that has recently gained in popularity among recreational users as an alternative to MDMA (Ecstasy). While considerable research into the consequences of MDMA use is available, much remains unknown about the neur...
Article
The hallucinogenic "designer drug" known as Foxy or Methoxy Foxy and formally know as 5-Methoxy-N,N-di(iso)propyltryptamine hydrochloride (5-MeO-DIPT) is rapidly gaining popularity among recreational users. However, little is known about the consequences of its use on neuropsychological development or behavior. During one of two adolescent periods,...

Citations

... High concentrations of 5-MeO-DIPT produced a marked cytotoxicity assessed by a cell viability assay in COS-7 cells [3]. Chronic 5-MeO-DIPT administration decreased 5-HT levels in the rat prefrontal cortex, striatum and hippocampus [7][8][9], which may suggest its neurotoxicity. Clinical data indicated potent multi-organ effects of 5-MeO-DIPT as the users experienced euphoria, disinhibition, increased sociability, and visual and auditory hallucinations, but also effects like mioclonus, restlessness, insomnia, anxiety, nausea, vomiting and diarrhea [10]. ...
... 17 Additional behavioral studies demonstrated that 5-MeO-DIPT given repeatedly to adolescent rats produced deleterious effects on learning and memory in adulthood. 18,19 These pharmacological results suggest that 5-MeO-DIPT stimulates not only serotonin function but also dopamine function. ...
... Therefore, the recorded escape latencies for the four start locations were normalized. Normalization involved the computation of the ratio of the minimum swim distance in centimeters for each of the two longer swim paths to the escape platform (e.g., north start location and a southwest goal location) to the minimum swim distance in centimeters of the two shorter swim paths (e.g., a north start location and a northeast goal location [34]. ...
... The toxic effects of 5-MeO-DIPT mainly include serotonergic neurotoxicity, oxidative DNA damage and disruption the endocrine system (3,4,(8)(9)(10)(11), while some users of 5-MeO-DIPT experienced hallucinations, euphoria and diated pupils (12,13). One fatality caused by excessive abuse of 5-MeO-DIPT has also been reported in the literature. ...