Mehmood Ali’s scientific contributions

e m b e r 2 0 2 4 , V o l. 5 , N o. 2 P a g e 18 | 9 ABSTRACT Objective: This study sought to compare the hemodynamic responses to laryngoscopy and tracheal intubation between Nalbuphine and Midazolam to assess their efficacy and safety in clinical practice. Study Design: Randomized Control Trial Place and Duration of the Study: Department of Anesthesia at Faculty of Allied Health Sciences, Superior University, Lahore and duration of the study was six months from jan 2024 to june 2024 Materials and Methods: A randomized controlled experiment Trial was performed at Department of Anesthesia Faculty of Allied Health Sciences involving 168 people, evenly split into two groups: Group N (Nalbuphine, n=84) and Group M (Midazolam, n=84). The inclusion criteria were patients aged 20 to 60 years, classified as ASA I or II, who were scheduled for laparoscopic cholecystectomy. Participants received either Nalbuphine or Midazolam preoperatively, and hemodynamic parameters (heart rate, systolic and diastolic blood pressure, mean arterial pressure, and SPO₂) were assessed at baseline and at 2, 4, 6, 8, and 10 minutes following intubation. Statistical analyses encompassed t-tests for group comparisons and regression analysis to ascertain drivers of mean arterial pressure. Results: The trial comprised 168 subjects, equally allocated to Group N (Nalbuphine) and Group M (Midazolam), with no statistically significant differences in demographic factors including age (p = 0.482), gender (p = 0.742), weight (p = 0.632), or surgical time (p = 0.601). Initially, hemodynamic parameters were comparable; however, post-induction, substantial differences emerged, with Group N demonstrating reduced heart rate (p = 0.001), systolic blood pressure (p = 0.000), diastolic blood pressure (p = 0.000), and mean arterial pressure (p = 0.000) at all time points. Regression analysis revealed significant predictors of mean arterial pressure (MAP), including heart rate (β = 0.45, p = 0.000), systolic blood pressure (BP) (β = 0.32, p = 0.001), and diastolic BP (β = 0.56, p = 0.000). Conversely, group membership exhibited a significant negative correlation (β =-5.25, p = 0.000), indicating a preference for Nalbuphine in achieving enhanced hemodynamic stability. Conclusion: The study determined that Nalbuphine offered superior hemodynamic stability relative to Midazolam during laryngoscopy and tracheal intubation in laparoscopic cholecystectomy. Nalbuphine was correlated with markedly reduced heart rate, blood pressure, and mean arterial pressure at all measured intervals. Comparative study of Nalbuphine verses Midazolam on hemodynamic response ....... J B K M C , J u l y-D e c e m b e r 2 0 2 4 , V o l. 5 , N o. 2 P a g e 19 | 9

Objective: to evaluate the knowledge, attitudes, and practices of operating theatre staff concerning CAUTI prevention at Health Sciences, Superior University, Lahore, Pakistan. Study Design: A Cross sectional Study Place and Duration of the Study: A cross-sectional study was performed with operating theater personnel, comprising physicians, nurses, and technicians, at Health Sciences, Superior University, Lahore.from jan to june 2024 Methodology: A standardized questionnaire was employed to assess participants' understanding of CAUTI causes, dangers, and preventative measures; attitudes towards CAUTI prevention; and compliance with suggested actions. Data were gathered and examined to pinpoint knowledge deficiencies and intervention opportunities. Results: The study measured the knowledge, attitude, and practices (KAP) of operating room staff with relation to preventing catheter-associated urinary tract infections (CAUTIs). The results showed that, on average, 1.8 out of a possible 5.0 points were deemed sufficient, and that 52.7% shown moderately adequate knowledge. A mean attitude score of 2.05 (SD = 0.75) was produced by the mixed attitudes, with 40.9% exhibiting somewhat positive attitudes and 29.1% indicating favorable attitudes. The staff's level of practice adherence varied; on average, 1.88 (SD=0.6), with 56.4% indicating moderate practice and 43.6% indicating adequate practice. Staff members acknowledged the significance of aseptic technique to a degree of 94.5%, and 79.1% were in favor of prompt catheter removal to avoid CAUTI, according to key responses. Higher levels of practice adherence were linked to more professional experience (χ² = 19.172, p < 0.01), and there were notable positive associations between attitude and practice (rho = 0.264, p < 0.01). Despite a moderate degree of knowledge and practice, patient safety can only be improved by targeted education that fills attitude gaps and enhances CAUTI prevention strategies. Conclusion: CAUTI is a common healthcare-associated disease. Healthcare personnel had sufficient CAUTI prevention knowledge, attitudes, and practices in this study. Every hospital's infection prevention program must create, implement, and monitor urinary catheter infection prevention policies. Health care organizations must establish medical education programs, interdisciplinary training, and catheter care checklist audits to improve staff knowledge and practices. Assessment Of Knowledge Attitude And Practices Of Operation Theatre …………. J B K M C , J u l y-D e c e m b e r 2 0 2 4 , V o l. 5 , N o. 2 P a g e 135 | 12

Background: The World Health Organization's Surgical Safety Checklist (SSC) has been identified as a pivotal tool for enhancing patient safety in operating rooms globally. Despite its proven efficacy, varying levels of knowledge and attitudes towards the SSC among healthcare professionals can influence its successful implementation. Objective: This study aimed to evaluate the knowledge and attitudes of operating room personnel towards the SSC at the Police and Services Hospital (P&SH) in Peshawar, Pakistan, identifying gaps and areas for improvement to facilitate better adoption and utilization of the SSC. Methods: A cross-sectional survey was conducted from November 2023 to January 2024 among 30 permanent staff members in the operating theaters at P&SH, including surgeons, nurses, anesthetists, and technicians. Participants were selected using convenience sampling. The survey comprised demographic questions, knowledge-based questions regarding the SSC, and items assessing attitudes towards the checklist. Data were analyzed using descriptive statistics to summarize demographic information, knowledge levels, and attitudes. Results: The study found that 93.3% of participants had heard of the SSC, with 93.3% demonstrating good knowledge and a positive attitude towards its implementation. However, 3.3% of the participants displayed poor knowledge, and a small fraction exhibited neutral or negative attitudes (6.7%). A significant majority (93.3%) expressed strong support for using the SSC in all surgical procedures, while concerns were raised about its potential to waste time and impact operating efficiency negatively. Conclusion: The high level of awareness and positive attitudes among operating room personnel at P&SH towards the SSC is encouraging. Nevertheless, the presence of knowledge gaps and efficiency concerns highlights the need for targeted educational interventions and strategies to address misconceptions and operational challenges. Enhancing the understanding and efficient use of the SSC can further solidify its role as a cornerstone of patient safety in surgical settings.