Max Kleiber’s scientific contributions

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Publications (1)


Body Size and Metabolism
  • Article

January 1932

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281 Reads

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2,159 Citations

Diogenes

Max Kleiber

Benedict has shown that this law is already over ninety years old, Robiquet and Tillaye having formulated it quite clearly in 1839. The history of the surface law is given in the paper of (Harris and Benedict (1919)). We may here only briefly mention the different ways in which it has been found. The early writers derived the law from theoretical considerations on a rather small experimental basis, as did Bergmann, who in 1847 had already written a book on the subject. Respiration trials were carried out by Regnault and Reiset, and Rameaux based the surface law on measurements of the amount of air respired per minute by two thousand human beings of different sizes. (Rubner (1883)) demonstrated the law in accurate respiration trials on dogs and Richet rediscovered it empirically on rabbits. The latter writes (p. 223): “C’est aprèe coup seulement que je me suis avisé que la donnée surface était plus intéressante que la donnée poids.”

Citations (1)


... Allometric scaling of pharmacokinetic parameters, particularly CL, is an established approach for scaling metabolic processes with body weight [29]. Although the allometric coefficient may vary based on population characteristics and drug properties, it is common to scale CL parameters to body weight using a fixed exponent of 0.75 [30,31], as was done in this analysis. This analysis did not combine scaling with a sigmoidal maturation function, which is common for neonates and infants aged < 2 years [32]. ...

Reference:

An Adult Population Pharmacokinetic Model to Simulate Subcutaneous Administration of a Fixed Dose of Furosemide in Adolescents with Heart Failure and Volume Overload
Body Size and Metabolism
  • Citing Article
  • January 1932

Diogenes