Matthijs J. H. M. van der Loos's research while affiliated with Erasmus University Rotterdam and other places
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Publications (20)
Replication results of the twenty suggestive SNPs (p<1×10−5) from the self-employment discovery meta-analyses for pooled males and females.
(DOC)
Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We repo...
Gene-based p-values for the top 25 genes associated with self-employment in the discovery meta-analysis for pooled males and females.
(DOC)
Gene-based p-values for the candidate entrepreneurship genes for pooled males and females, males only, and females only.
(DOC)
Study design, sample size, sample quality control, and self-employment measure within each study.
(DOC)
Meta-analysis association results for SNP rs1486011 for pooled males and females, males only, and females only.
(DOC)
Results of the prediction analyses in STR for pooled males and females, males only, and females only.
(DOC)
Genomic inflation factors.
(DOC)
Genotyping, imputation, SNP quality control, and statistical analysis within each study.
(DOC)
Replication results of the sixteen suggestive SNPs (p<1×10−5) from the self-employment discovery meta-analyses for females only.
(DOC)
Gene-based p-values for the top 25 genes associated with self-employment in the discovery meta-analysis for females only.
(DOC)
Replication results of the 22 suggestive SNPs (p<1×10−5) from the self-employment discovery meta-analyses for males only.
(DOC)
Gene-based p-values for the top 25 genes associated with self-employment in the discovery meta-analysis for males only.
(DOC)
Preferences are fundamental building blocks in all models of economic and political behavior. We study a new sample of comprehensively genotyped subjects with data on economic and political preferences and educational attainment. We use dense single nucleotide polymorphism (SNP) data to estimate the proportion of variation in these traits explained...
The costs of comprehensively genotyping human subjects have fallen to the point where major funding bodies, even in the social sciences, are beginning to incorporate genetic and biological markers into major social surveys. How, if at all, should economists use and combine molecular genetic and economic data from these surveys? What challenges aris...
Candidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting
these studies is not straightforward because the selection of candidates influences the interpretation of the results. As
an example, Nicolaou et al. (Small Bus Econ 36:151–155, 2011) report a significant association...
Twin and adoption studies have consistently found that genetic variation is an important source of heterogeneity in economic outcomes such as educational attainment and income. The advent of inexpensive, genome-wide scans is now making it increasingly feasible to directly examine specific genetic variants that predict individual differences. In thi...
The recently developed genome-wide association study (GWAS) design enables the identification of genes specifically associated
with economic outcomes such as occupational and other choices. This is a promising new approach for economics research which
we aim to apply to the choice for entrepreneurship. However, due to multiple testing issues, very...
We are currently investigating genetic influences on self-employment in an international research consortium using genome-wide association studies (GWAS). By meta-analysing results from numerous independent samples we address identification issues arising from multiple testing. To our knowledge, this is the earliest attempt to apply GWAS to an econ...
Citations
... A recent meta-analysis on studies measuring endogenous levels of testosterone showed a significant albeit small correlation between testosterone and risk-taking which was not influenced by gender nor by outcome measures (Kurath and Mata, 2018). Nevertheless, several other studies reported contrasting see Mehta et al. (2015) or null results (Van der Loos et al., 2013;Derntl et al., 2014;Nadler et al., 2021;Stanton et al., 2021). However, it should be noted that these studies used different approaches with some measuring basal testosterone in saliva (Derntl et al., 2014;Mehta et al., 2015), some in the serum (Van der Loos et al., 2013), while the rest (Nadler et al., 2021;Stanton et al., 2021) administered testosterone exogenously. ...
... In this quest, a multitude of state-of-the-art research tools have been utilized, and genetics research has emerged as the most promising way of deciphering the presumed "secrets" of the "entrepreneurial nature" (Nicolaou & Shane, 2009;Nicolaou, Phan & Stephan, 2021). Yet, the success of such efforts is questionable, and we still do not know what is so "special" about entrepreneurs (van der Loos, 2013;Rietveld, Slob & Thurik, 2021). Likewise, entrepreneurial alertness is routinely posited as a "rare gift" that enables only a few to recognize opportunities in an otherwise uncertain future (Moore, McIntyre & Lavinich, 2021;Neneh, 2019;Shane & Venkataraman, 2000). ...
Reference: From Better Answers to Better Questions
... With these genetic data, genetic epidemiologists started to search for the specific genes influencing heritable diseases and traits such as heart disease, diabetes, autoimmune diseases, and psychiatric disorders (Visscher et al., 2012). Motivated by the idea that matches and mismatches between genetic predispositions and career choices could impact morbidity and mortality Van der Loos et al., 2010), an international consortium was set up to analyze the molecular genetic architecture of entrepreneurship using genome-wide association study (GWAS) metaanalysis ( Van der Loos et al., 2011;Van der Loos et al., 2013). ...
... The ride can cost as much as the emergency room visit, ranging between $300 and $1200 (approximately a $750 average), tacking on fees for mileage and oxygen. This suggests that a 6.96 percent chance (based on a 327 million population) exists that someone living in a United States household will be assisted by an emergency medical service call in any given year (22,750,500 medical calls/327,000,000 households). The $48 membership would have an expected benefit of $31.32 [($750 * 60 percent) * 0.0696)] and a return of 65.25 cents ($31.32/$48) for every dollar invested into the medical service membership program. ...
... Twin studies from different countries show that political ideology and beliefs (e.g., Alford et al., 2005;Hatemi et al., 2014;Ksiazkiewicz et al., 2020) and political interest have a heritable component (Bell et al., 2009;Dawes et al., 2014;Klemmensen et al., 2012;Weinschenk et al., 2019). Different methodologies, such as extended family designs (Hatemi et al., 2010) and the analysis of genome-wide data (Benjamin et al., 2012), have led to similar conclusions. Studies also suggest that the role of genes in political attitudes emerges primarily in early adulthood and is absent in adolescence (Eaves et al., 1997;Hatemi, Funk, et al., 2009). ...
... An article (only for risk aversion) [26], comprehensively addressed the possible association between more than 2 million single nucleotide polymorphisms (SNPs) extracted from the U.S. Health and Retirement Study (HRS), and the risk-aversion level, measured with hypothetical gambles on lifetime income, in a sample of 10,455 adults. The remaining articles included in the review dealt with more specific genetic measures, known as "candidate-gene" studies [41]. They studied specific genetic markers (one or several genes, or regions thereof), since, based on prior knowledge of their biological functions, these could be related to the phenotype of interest (in this case, risk or loss aversion). ...
... At the heart of this emerging landscape are healthcare professionalsindividuals uniquely positioned to harness the potential of genomics for entrepreneurial endeavors that can revolutionize healthcare delivery. However, this intersection of genomics and entrepreneurship does not face challenges [4]. Attitudes, beliefs, and perceptions held by healthcare professionals play a pivotal role in shaping their intentions to venture into the entrepreneurial domain of genomics [5]. ...