Mathieu Goussé's research works | Université Grenoble Alpes, Grenoble and other places

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Ubiquinone Biosynthesis over the Entire O 2 Range: Characterization of a Conserved O 2 -Independent Pathway

Article

Full-text available

Jul 2019

In order to colonize environments with large O 2 gradients or fluctuating O 2 levels, bacteria have developed metabolic responses that remain incompletely understood. Such adaptations have been recently linked to antibiotic resistance, virulence, and the capacity to develop in complex ecosystems like the microbiota. Here, we identify a novel pathwa...

Ubiquinone biosynthesis over the entire O 2 range: characterization of a conserved, O 2 -independent pathway

Preprint

Full-text available

Jun 2019

Most bacteria can generate ATP by respiratory metabolism, in which electrons are shuttled from reduced substrates to terminal electron acceptors, via quinone molecules like ubi quinone. Dioxygen (O 2 ) is the terminal electron acceptor of aerobic respiration and serves as a co-substrate in the biosynthesis of ubi quinone. Here, we characterize a no...