Masoudeh Etesam’s research while affiliated with University of Tehran and other places

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Publications (2)


Contribution of each process – adsorption, accumulation, biodegradation, and photodegradation (non‐biodegradation) – to the removal of the drugs after 14 days of Trichormus variabilis growth.
Time courses of biomass production for the Trichormus variabilis culture (P < 0.05) in the presence of different amounts of ranitidine (50, 150, and 250 mg L–1) (a), tramadol (20, 60, and 100 mg L–1) (b), and gabapentin (100, 150, and 200 mg L–1) (c) in comparison with the control media containing no drug.
Time courses of the ratio of total chlorophyll per gram of biomass for Trichormus variabilis culture (P < 0.05) in the presence of different amounts of ranitidine (50, 150, and 250 mg L–1) (a), tramadol (20, 60, and 100 mg L–1) (b), and gabapentin (100, 150, and 200 mg L–1) (c) in comparison with the control media containing no drug.
Time courses of the ratio of total carotenoids per gram of biomass for Trichormus variabilis culture (P < 0.05) in the presence of different amounts of ranitidine (50, 150, and 250 mg L–1) (a), tramadol (20, 60, and 100 mg L–1) (b), and gabapentin (100, 150, and 200 mg L–1) (c) in comparison with the control media containing no drug.
Effect of different concentrations of ranitidine, tramadol, and gabapentin on the production of protein (mg) per gram of biomass during culture of Trichormus variabilis (P < 0.05) compared to the control case.

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Removal of pharmaceutical compounds (ranitidine, tramadol, and gabapentin) from wastewater by Trichormus variabilis microalgae
  • Article
  • Publisher preview available

January 2024

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57 Reads

Masoudeh Etesam

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Esmail Borhani Fard

Wastewater effluent from the pharmaceutical, cosmetic, and chemical industries often contains pharmaceutical contaminants, making the reuse of wastewater a controversial practice. Physical and chemical methods have been unsuccessful in removing these pollutants on a large scale. Microalgal technology has been introduced as a promising tool to tackle this issue. This study evaluated the performance of Trichormus variabilis microalgae in removing three contaminants, namely ranitidine, tramadol, and gabapentin. Three concentrations of each compound were introduced into the microalgal culture medium. The effect of these pharmaceutical concentrations on growth, biomass production, photosynthetic pigments, and protein and lipid content was evaluated and compared with control cultures over 14 days. It was found that T. variabilis was able to remove 61–100% of these drugs. Moreover, the addition of 250 mg L–1 of ranitidine to the algae culture medium led to a 33.4% reduction in biomass growth. Adding 20 mg L–1 of tramadol and 200 mg L–1 of gabapentin caused 30% and 19.2% biomass reductions, respectively. The presence of 100 mg L–1 of gabapentin led to a 38% and up to 14% increase in chlorophyll and carotenoid content in comparison with the control, while the presence of the other drugs reduced the content of chlorophyll and carotenoid. On the other hand, the protein content increased by 254% in the culture media compared to the control media in the presence of 50 mg L–1 ranitidine. Regarding lipid concentration, 20 mg L–1 of tramadol had the most important effect by doubling the lipid content in T. variabilis in comparison with the control. In conclusion, these drugs could be removed to a significant extent by T. variabilis, which is promising for larger scale applications.

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Investigation of pharmaceutical compounds (Metronidazole, Rosuvastatin and Codeine phosphate) removal by Synechocystis sp. PCC6803 microalga

June 2022

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51 Reads

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10 Citations

Journal of Water Process Engineering

The uncontrolled entry of pharmaceutical compounds (PCs) into water sources causes irreversible damages to microorganisms. This study aimed to evaluate the capability of Synechocystis sp. PCC6803 microalga to remove three PCs, namely Metronidazole in 1, 3, and 5 mg/L, Rosuvastatin in 200, 400, and 600 mg/L, and Codeine phosphate in 50, 150, and 250 mg/L. These PCs have not been effectively removed by chemical and physical wastewater treatment methods. Adding Metronidazole to the culture medium resulted in a 70% reduction in biomass production; while the amount of protein produced at the concentration of 5 mg/L increased about 3 times compared to the control culture. The culture medium containing 600 mg/L Rosuvastatin increased the total lipid production by more than 50%. The biomass and protein produced in culture medium containing Codeine phosphate were not significantly different compared with the control. Moreover, the drugs removal efficiency of Synechocystis was 80% for Metronidazole and almost 100% for Rosuvastatin and Codeine Phosphate. Metronidazole, which is a lipophilic drug, bonds to the cell surface of microalgae through the formation of chemical bonds between its aromatic rings and functional groups on the surface of extracellular substrates. However, Rosuvastatin and Codeine phosphate which are hydrophilic drugs can enter the cells, where they are degraded by intra-cellular enzymatic mechanism; thus, they were removed by cell biodegradation mechanism in cells. The findings of this study can be potentially used in e.g., hospital wastewater treatment sustainably and economically using microalgae in the future.

Citations (1)


... In simple terms, living organisms frequently grow well in low toxin concentrations, which prove fatal at high concentrations. Within a microalgal biotechnology context, the hormetic effects of antibiotics (Bahman et al., 2022;Kiki et al., 2022;Xiong et al., 2017), herbicides (Solomonova et al., 2024;Spoljaric et al., 2011;Wang et al., 2024a), heavy metals (Ameri et al., 2020;Xu et al., 2024;Zhang et al., 2024), microplastics (Chen et al., 2021;Xu et al., 2023), nanomaterials (Hurtado-Gallego et al., 2020;Xia et al., 2015), and even ionizing radiation Stanić et al., 2024) have been documented by various research groups. Recently, there has been an upsurge in the number of studies reporting the effect of xenobiotics on algal physiology and/or metabolism (Stanić et al., 2024;Wang et al., 2024a,b;Xu et al., 2023;Zhang et al., 2024;Zhou et al., 2024). ...

Reference:

Effects of antibiotic supplementation vs. nutrient stress on α-linolenic acid and α-tocopherol in Scenedesmus sp
Investigation of pharmaceutical compounds (Metronidazole, Rosuvastatin and Codeine phosphate) removal by Synechocystis sp. PCC6803 microalga
  • Citing Article
  • June 2022

Journal of Water Process Engineering