Masoud Mozafari's research while affiliated with Tehran University of Medical Sciences and other places

Publications (433)

Article
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus is a highly contagious microorganism, and despite substantial investigation, no progress has been achieved in treating post-COVID complications. However, the virus has made various mutations and has spread around the world. Researchers have tried different treatments to reduce the s...
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Targeted drug delivery systems using nanocarriers offer a versatile platform for breast cancer treatment; however, a robust, CD44-targeted niosomal formulation has not been developed and deeply studied (both in vitro and in vivo) yet. Here, an optimized system of epirubicin (Epi)-loaded niosomal nanoparticles (Nio) coated with hyaluronic acid (HA)...
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After several billions of years, nature still makes decisions on its own to identify, develop, and direct the most effective material for phenomena/challenges faced. Likewise, and inspired by nature, we learned how to take steps in developing new technologies and materials innovations. Wet and strong adhesion by Mytilidae mussels (among which Mytil...
Article
This century is blessed with enhanced medical facilities on the grounds of the development of smart biomaterials. The rise of the four-dimensional (4D) bioprinting technology is a shining example. Using inert biomaterials as the bioinks for the three-dimensional (3D) printing process, static objects that might not be able to mimic the dynamic natur...
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The reconstruction of chronic skin wounds remains a public health challenge in dermatology. Precisely controlling and monitoring the wound‐healing process should result in enhanced outcomes for the patient. Cell‐based therapies have shown great potential in medicine due to their immunomodulatory and healing properties. Herein, we produced activated...
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Nickel–titanium (NiTi) is a shape-memory alloy, a type of material whose name is derived from its ability to recover its original shape upon heating to a certain temperature. NiTi falls under the umbrella of metallic materials, offering high superelasticity, acceptable corrosion resistance, a relatively low elastic modulus, and desirable biocompati...
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Designing biomaterials capable of biomimicking wound healing and skin regeneration has been receiving increasing attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting biointerfacial adhesion and intrinsic cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer that endow...
Article
Hydrogels play a key role in cartilage tissue engineering (CTE) and cell transplantation. Idealy, the hydrogels designed for CTE should facilitate the formation of cartilage ECM, cilinically. However, challenges remain to engineer hydrogels with controllable responses, fast‐self recovery, and high stability. In the present study, a dual crosslinked...
Article
In recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and has become particularly emphasized. Currently, by the extraordinary development of nanomaterials in different fields of medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) by t...
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In recent decades, we have witnessed radical changes in the use of permanent biomaterials. The intrinsic ability of magnesium (Mg) and its alloys to degrade without releasing toxic degradation products has led to a vast range of applications in the biomedical field, including cardiovascular stents, musculoskeletal, and orthopedic applications. With...
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Since the rapid onset of the COVID‐19 or SARS‐CoV‐2 pandemic in the world in 2019, extensive studies have been conducted to unveil the behavior and emission pattern of the virus in order to determine the best ways to diagnosis of virus and thereof formulate effective drugs or vaccines to combat the disease. The emergence of novel diagnostic and the...
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In this study, a three-dimensional composite scaffold is proposed consisting of polylactic acid and spray dried glass-ceramic microparticles (SGCMs). The compositional and structural characterization showed that the obtained spray dried powder formed as glass-ceramic (GC) with a completely interconnected porosity structure. Before direct printing o...
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Implantation of a suitable nerve guide conduit (NGC) seeded with sufficient Schwann cells (SCs) is required to improve peripheral nerve regeneration efficiently. Given the limitations of isolating and culturing SCs, using various sources of stem cells, including mesenchymal stem cells (MSCs) obtained from nasal olfactory mucosa, can be desirable. O...
Chapter
Blood vessels formation is a complex biological process in the body, which plays critical roles throughout human life, ranging from embryo development to tissue healing. Numerous experimental studies have tried to uncover the cellular and molecular mechanisms involved in neovascularization for providing detailed information about its status in phys...
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The advent of 3D-printing/additive manufacturing in the biomedical engineering field has introduced great potential for the preparation of 3D structures that can mimic native tissues. This technology has accelerated the progress in numerous areas of regenerative medicine, especially leading to a big wave of biomimetic functional scaffold developmen...
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Architecting an appropriate platform for biomedical applications requires setting a balance between simplicity and complexity. Polysaccharides (PSAs) play essential roles in our life in food resources, structural materials, and energy storage capacitors. Moreover, the diversity and abundance of PSAs have made them an indispensable part of food ingr...
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Although the World Health Organization (WHO) announcement released in early March 2020 stated there is no proven evidence that the COVID-19 virus can survive in drinking water or sewage, there has been some recent evidence that coronaviruses can survive in low-temperature environments and in groundwater for more than a week. Some studies have also...
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MOFs exhibit inherent extraordinary features for diverse applications ranging from catalysis, storage, and optics to chemosensory and biomedical science and technology. Several procedures including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasound techniques have been used to synthesize MOFs with tailored features. A cont...
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New emerging technologies, remarkably miniaturized 3D organ models and microfluidics, enable simulation of the real in vitro microenvironment ex vivo more closely. There are many fascinating features of innovative organ‐on‐a‐chip (OOC) technology, including the possibility of integrating semipermeable and/or stretchable membranes, creating continuo...
Article
In this study, a magnesium oxide - titanium dioxide (MgO-TiO2) composite coating was successfully applied to the surface of magnesium-based implants by a plasma electrolytic oxidation (PEO) technique in an electrolyte solution containing TiO2 nanoparticles. A uniform top-layer polycaprolactone (PCL) coating was eventually formed on the PEO-treated...
Article
Osteoporosis (OP) is characterized by decreased bone mineral density and impaired bone strength. Carfilzomib (CFZ) is a new-generation proteasome inhibitor and has been found to affect bone metabolism. However, the effect and mechanism of CFZ on OP has not been investigated systematically. In this study, we found that protein levels of proteasome a...
Article
In this study, calcium, phosphorus, and copper co-incorporated titanium oxide (TiO2) layers were prepared on titanium substrates using the plasma electrolytic oxidation process. Thereafter, their features were studied to be used in dental implants. Surface characterization revealed that the addition of calcium and copper ions to the phosphate-based...
Article
Strategies of Schwann cell (SC) transplantation for regeneration of peripheral nerve injury involve many limitations. Stem cells can be used as alternative cell source for differentiation into Schwann cells. Given the high potential of neural crest-derived stem cells for the generation of multiple cell lineages, in this research, we considered wheth...
Preprint
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Introduction: Fabricating composite scaffolds with improved physicochemical properties as artificial microenvironments are of great interest in bone tissue engineering. Given advantageous properties of nano-hydroxyapatite/chitosan/gelatin (nHA/Cs/Gel) scaffolds, the present study aimed to synthesize a modified nHA/Cs/Gel biomimetic scaffold with im...
Article
In this study, a magnesium oxide - titanium dioxide (MgO-TiO2) composite coating was successfully applied to the surface of magnesium-based implants by a plasma electrolytic oxidation (PEO) technique in an electrolyte solution containing TiO2 nanoparticles. A uniform top-layer polycaprolactone (PCL) coating was eventually formed on the PEO-treated...
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There have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine‐based biomaterials can not only be used...
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The study highlights the corrosion behavior of untreated and treated tantalum with addition of trimanganese tetraoxide (Mn3O4) nanoparticles in simulated inflammatory media. The anodic layer was produced on pure tantalum by anodization in electrolytes composed of ammonium fluoride, ethylene glycol, and water. Nanoparticles were deposited uniformly...
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The brain drain crisis is among the most challenging issues of many developing countries, attributed to the compounding effects of multiple factors. As communities and their challenges become more complex, new sets of mixed research tools that critically investigate these issues as whole systems rather than isolated parts are crucial for future dec...
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Progress in materials science has developed the boundaries of additive manufacturing (AM) technology by offering a breathtaking forum for interdisciplinary research in medical science. Recently, with a growing interest in stimuli-responsive materials, a new concept called four-dimensional (4D) bioprinting, which has determined time as the 4th dimen...
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Cancer is a genetic disease associated with the rapid growth of abnormal cells, which provoked the death of almost 10 million people worldwide during 2020 (WHO, 2021a), placing it among the top 10 causes of death worldwide (WHO, 2021b). In this context, numerous efforts have been made with the aim of preventing, detecting and treating this disease...
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The composition and topology of metal-organic frameworks (MOFs) are exceptionally tailorable; moreover, they are extremely porous and represent an excellent Brunauer–Emmett–Teller (BET) surface area (≈3000–6000 m2·g−1). Nanoscale MOFs (NMOFs), as cargo nanocarriers, have increasingly attracted the attention of scientists and biotechnologists during...
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List of contributors for the Book named "Magnetic Nanoparticle-Based Hybrid Materials" by Woodhead Publishing Series in Electronic and Optical Materials, 2021, Pages xv-xxi.
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Carbon-based nanocarriers such as multiwall carbon nanotubes (MWCNTs) and reduced graphene oxide (rGO) have shown promising delivery capabilities due to their low immunogenicity, superior internalization, and suitable cell penetration efficiency. Herein, a molecular engineering strategy is advanced for the one-pot synthesized rGO/MWCNT/Fe 3 O 4 /Zn...
Article
Hybrid bioactive inorganic–organic carbon-based nanocomposites of reduced graphene oxide (rGO) nanosheets enlarged with multi-walled carbon nanotubes (MWCNTs) were decorated to provide a suitable space for in situ growth of CoNi2S4 and green-synthesized ZnO nanoparticles. The ensuing nanocarrier supplied π–π interactions between the DOX drug and a...
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Citation: Peyravian, N.; Malekzadeh Kebria, M.; kiani, J.; Brouki Milan, P.; Mozafari, M. CRISPR-Associated (CAS) Effectors Delivery via Microfluidic Cell-Deformation Chip. Abstract: Identifying new and even more precise technologies for modifying and manipulating selectively specific genes has provided a powerful tool for characterizing gene funct...
Article
The emergence of smart materials (also known as stimuli-responsive materials) has significantly developed the boundaries of modern medicine. This class of materials can operate as an ‘on-off’ switch for multiple applications from nano-to macrometer scale due to their unique characteristics responsive to the environmental changes. As for illustratio...
Article
A one-pot and facile method with assistance of high gravity was applied for the synthesis of inorganic two-dimensional MOF-5 embedded MXene nanostructures. The innovative inorganic MXene/MOF-5 nanostructure was applied in co-delivery of drug and gene, and to increase its bioavailability and interaction with the pCRISPR, the nanomaterial was coated...
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Polysaccharides are the most abundant naturally available carbohydrate polymers; composed of monosaccharide units covalently connected together. Chitosan is the most widely used polysaccharides because of its exceptional biocompatibility, mucoadhesion, and chemical versatility. However, it suffers from a few drawbacks, e.g. poor mechanical properti...
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As promising biodegradable materials with nontoxic degradation products, magnesium (Mg) and its alloys have received more and more attention in the biomedical field very recently. Having excellent biocompatibility and unique mechanical properties, magnesium‐based alloys currently cover a broad range of applications in the biomedical field. The use...
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The recent outbreak of Coronavirus Disease 2019 (COVID-19) calls for rapid mobilization of scientists to probe and explore solutions to this deadly disease. A limited understanding of the high transmissibility of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) relative to other coronavirus strains guides a deeper investigation into the...
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Originating from a combination of neuroscience and biomedical engineering strategies, neuroprosthetics are developed as substitutes for sensory or cognitive modality damages caused by an injury or a disease. Dry electrodes are essential devices for monitoring of the biopotential such as electroencephalography (EEG) and electrocardiography (ECG). In...
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Tissue engineering intends to create functionalized tissues/organs for regenerating the injured parts of the body using cells and scaffolds. A scaffold as a supporting substrate affects the cellular activity such as attachment, proliferation, migration, and differentiation into specific tissue. Hydrogel as a biomimetic scaffold plays a vital role i...
Article
In this study, doped strontium fluorapatite (Sr-FAP) nanopowders were synthesised by sol-gel and used as a coating to modify Ti-6Al-4V substrates through CO2 laser cladding. The Ca ions of FAP were substituted by a different amount of Sr ions to increase bone cell differentiation and antibacterial properties. Lattice parameters and crystal size val...
Article
In this study, the chondrogenic potential of hyaluronic acid/chondrotin sulfate/carboxymethyl chitosan hydrogels with adipose‐derived mesenchymal stem cells (ADMSCs) was evaluated. Here, hyaluronic acid, chondrotin sulphate and carboxymethyl chitosan were used as the substrate for cartilage tissue engineering in which the hydrogel is formed due to...
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With an escalating incidence of breast cancer cases all over the world and the deleterious psychological impact that mastectomy has on patients along with several limitations of the currently applied modalities, it's plausible to seek unconventional approaches to encounter such a burgeoning issue. Breast tissue engineering may allow that chance via...
Article
The concept of providing tissue engineering scaffolds with natural physical properties and minimal immunogenicity has not been systematically approached for the lungs yet. Here, the rat acellular lung tissue (ALT) was cross-linked to provide either EDC/NHS cross-linked tissue (EDC/NHS-CLT) or tannic acid cross-linked tissue (TA-CLT). Young’s modulu...
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Despite the success of recombinant adenovirus serotype 5 (Ad5) and dioleoyltrimethylaminopropane:cholesterol (DOTAP:Chol) liposomes as viral and nonviral vectors in clinical trials, these vectors still suffer from drawbacks such as high immunogenicity and low transfection efficiency, respectively. To address these issues, some researchers have synt...
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Over the last years, three-dimensional (3D) printing has been successfully applied to produce suitable substitutes for treating bone defects. In this work, 3D printed composite scaffolds of polycaprolactone (PCL) and strontium (Sr)- and cobalt (Co)-doped multi-component melt-derived bioactive glasses (BGs) were prepared for bone tissue engineering...
Article
A novel SARS-like coronavirus (severe acute respiratory syndrome-related coronavirus-2, SARS-CoV-2) outbreak has recently become a worldwide pandemic. Researchers from various disciplinary backgrounds (social to natural science, health and medicine, etc.) have studied different aspects of the pandemic. The current situation has revealed how the ong...
Chapter
Magnetic nanoparticles (MNPs) are a very interesting class of metal oxides, which can be magnetized by an external field. The magnetic properties of MNPs give them potential for heat generation and actuation, which are highly appealing for in vivo applications. MNPs can be served as contrast agents for magnetic resonance imaging in cancer screening...
Article
The main goal of this research is to scrutinize the effect of texture and grain size on the biological response of hierarchical structured pure titanium (Ti), examining the interrelation between grain refinement mechanisms with texture variation. The hierarchical structure was produced using two methods of severe plastic deformation (SPD). The Ti s...
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In this study, 5 different electrospun chitosan-based scaffolds were fabricated for wound healing applications using benign solvents. Researchers have reported that chitosan/PEO scaffolds are generally unstable in aqueous solutions and have poor mechanical properties particularly in wet conditions, therefore we had to tackle these problems by modif...
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Hydrogels are the most iconic class of soft materials and since their first report in the literature has attracted the attention of uncountable researchers. Over the past two decades, hydrogels become smart and sophisticated materials with plenty of applications possibilities. The biomedical research area has demonstrated a particular interest in h...
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Diaphragmatic wall defects caused by congenital disorders or disease remain a major challenge for physicians worldwide. Polymeric patches have been extensively explored within research laboratories and the clinic for soft tissue and diaphragm reconstruction. However, patch usage is usually associated with allergic reaction, infection, granulation,...
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Copper is one of the most used therapeutic metallic elements in biomedicine, ranging from antibacterial approaches to cancer theranostics. This element could be easily incorporated into different types of biomaterials; specifically, copper-doped bioactive glasses (BGs) provide great opportunities for biomedical engineers and clinicians as regards t...
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Millions of people around the world are in distress due to neurodegenerative disorders. There have been continued attempts to design biomaterial-based therapies for the regeneration of dysfunctional neural tissues, mainly damaged peripheral nerve and spinal cord. The development of nerve guidance channels, where the distal and proximal end of a dam...
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The ability of mesenchymal stem cells (MSCs) to enhance cutaneous wound healing has been well established. Extensive expansion of cells to reach sufficient cell numbers for regenerating tissues has always limited cell-based therapies. An ingenious solution to address this challenge is to develop a strategy to increase the immunomodulatory effects o...
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Quantum dots (QDs) are semiconductor materials that have gained great interests due to their unique characteristics like optical properties. They are categorized into two distinct groups including cadmium‐based (e.g., CdTe, CdSe) and cadmium‐free ones (e.g., InP, InAs, CuInS2, Ge, Si, ZnS, and graphene QDs). They are extensively being used in diffe...
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Tissue engineering is an emerging field of study that incorporates the principles of medicine, biology and engineering for designing biological substitutes to restore, maintain or improve tissue functions. To fabricate a functional tissue, the engineered structures should mimic the extracellular matrix (ECM), enable oxygen and nutrient circulation...
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In this study, a series of electrospun chitosan/polyethylene oxide (PEO) nanofibrous scaffolds containing different amount of cerium-doped bioactive glasses (Ce-BGs) have been fabricated and proposed for tissue engineering applications. On a biological level, higher 8Ce-BG content significantly improved cytocompatibility of the scaffolds. Moreover,...
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Submicron biomaterials have recently been found with a wide range of applications for biomedical purposes, mostly due to a considerable decrement in size and an increment in surface area. There have been several attempts to use innovative nanoscale biomaterials for tissue repair and tissue regeneration. One of the most significant metal oxide nanop...
Chapter
The extracellular matrix as a microenvironment and supportive structure of the cells has a nanostructured architecture. Therefore, producing the biomaterials with nanostructure morphology improve the biocompatibility and hemocompatibility of these products. This book chapter describes the importance of cardiovascular biomaterials and the hemocompat...
Chapter
The implanted biomaterial is a competitive site for adhesion and colonization of bacteria and formation of biofilm layer. Antifouling surfaces by repelling the adhesion of bacteria and bactericidal surfaces by killing the bacteria after adhesion can prevent the colonization of microorganisms. Nanoparticles with high capacity for therapeutics loadin...
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Agarose is a prominent marine polysaccharide representing reversible thermogelling behavior, outstanding mechanical properties, high bioactivity, and switchable chemical reactivity for functionalization. As a result, agarose has received particular attention in the fabrication of advanced delivery systems as sophisticated carriers for therapeutic a...
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Theranostic platforms bring about a revolution in disease management. During recent years, theranostic nanoparticles have been utilized for imaging and therapy simultaneously. Zeolites, because of their porous structure and tunable properties, which can be modified with various materials, can be used as a delivery agent. The porous structure of a z...
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Cerium oxide nanoparticles (CeO2-NPs) have great applications in different industries, including nanomedicine. However, some studies report CeO2-NPs-related toxicity issues that limit their usage and efficiency. In this study, the sol–gel method was applied to the synthesis of CeO2-NPs using poly(allylamine) (PAA) as a capping and/or stabilizing ag...
Chapter
Diabetes mellitus is an endocrine disorder that is mainly classified into two types, type 1 and type 2. Type 1 diabetes occur when there islack or absence of insulin secretion by β-cells of the pancreas. Type 1 diabetes is also known as juvenile diabetes and 10% of all diabetes mellitus cases suffering from this type. Whereas, type 2 diabetes is th...
Chapter
Pulmonary and nasal pathways remained the appropriate routes for drugs delivery since ancient times. The effect of certain drugs could be more efficient and suitable through these pathways. The advances in nanotechnology has increase interests in the lung to use as a major route of drug delivery for both systemic and local treatments. Especially, t...
Chapter
The lung is one of the most important organs in the respiratory system and is primarily responsible for the exchange of oxygen and carbon dioxide gases between the cells of the body and the environment. As a result, lung disease is widely recognized as one of the world's primary causes of morbidity and mortality. Lung carcinoma has been confirmed t...