Masaru Tanaka's research while affiliated with Tokyo Women's Medical University and other places

... Based on the fundamentally artificial nature of the transgenic strategy (Ting & Feng, 2014), one alternative approach to circumvent such undesirable recombination is to employ a knockin approach, which can readily achieve targeted Cre expression precisely reflecting endogenous gene expression (Fan et al., 2019). To date, several melanocyte-targeted Cre knock-in lines, including Dct Cre (Guyonneau et al., 2002), Dct CreERT2 (Eshiba et al., 2021), (Yang et al., 2018), and Pmel CreERT2 (Mort et al., 2016), have been generated. ...

... In 19 cases, the presence of hypopyon sign was found, with two colors coexisting in a single lacuna -the dark component was associated with blood sedimentation, and the lighter one with the presence of dilated lymphatic channels. In other studies on dermoscopic presentation of AL of the vulva, presence of structures such as lacunas and white lines was also most often found [6][7][8]. ...

... We did not observe gray-whitish veils, brown dots, or purplish vessels [8]. Dermoscopic features of HHT described are small red clods and thick serpentine and linear vessels with a somewhat radial arrangement on a pinkish background [9]. The two cases in this series showed irregular pink to red structureless areas and occasional red dots ( Figure 2C). ...

... В ряде опубликованных работ по изучению иммунопатологических механизмов развития ГПП указана центральная роль гиперэкспрессии IL-36 или мутации с потерей функции его антагониста ИЛ-36R в патогенезе пустулезного псориаза. Неконтролируемая активация сигнального пути ИЛ-36 стимулирует продукцию медиаторов, например CCL20, MIP-1β, ФНО-β, ИЛ-12, ИЛ-17, ИЛ-23, TGF-β, что ведет к дальнейшему развитию воспаления и возникновению ГПП [7,8,14,15]. ...

... 53 Dermoscopy Literature search showed one case report describing dermoscopic features of methotrexate-associated lymphoproliferative disorder which included dotted/glomerular vessels over pink background and white scale. 54 The most frequent dermoscopic structures in specific PCL subtypes Structures most commonly observed in classical MF were fine short linear vessels/linear vessels (77/108; 71.3%), spermatozoalike vessels (48/108; 44.4%) and orange-yellow patchy areas (46/ 108; 42.6%). ...

... только 2 источника с описанием дермоскопически-гистологической корреляции при этой форме ГМ. Таким дермоскопическим признакам, как точечные и гломерулярные сосуды или точечные сосуды и сосуды в виде шпилек на фоне ретикулярных коричневых областей на розовато-белом/белом фоне, могут соответствовать расширенные кровеносные сосуды в папиллярной и ретикулярной дерме, отложение базального пигмента, а также наличие меланофагов в верхних слоях дермы [12,13]. Эритродермический вариант ГМ клинически характеризуется наличием диффузной эритемы, занимающей более 80% поверхности кожи, при этом диагностические критерии синдрома Сезари должны быть негативными. ...

... Most authors believe that cutaneous WD is derived from the hair follicle because of its closeness or clear-cut connection to pilosebaceous unit, 3,5-7,9 thereby suggesting that "follicular dyskeratoma" might be a better term for this entity. 6 A study performed with human keratin antibodies, specific for cortex and inner root sheet of normal human hair, 8 and a survey carried out searching the expression of cytokeratins CK 1 , CK 5 , Ck 10 , CK 17 , CK 19 5 confirmed this hypothesis. WD arising in regions devoid of follicular structures (oral mucosa 12 and nail bed 13,14 ) may represent examples of isolated FAD secondary to a local inflammation or a neoplastic proliferation. ...

... In addition to being clinically similar to a range of other benign and malignant tumours, pigmented poroma is also considered a great dermatoscopic imitator. Hence, in der-moscopy we can find blue-grey ovoid nest and arborizing vessels mimicking a basal cell carcinoma (5), and we can observe comedo-like openings and hairpin vessels simulating a seborrhoeic keratosis, or blue-whitish veil, setting differential diagnosis with malignant melanoma (6). Minagawa & Koga (6) observed that the most frequent dermatoscopic structures in pigmented poromas were vascular structures (hairpin vessels, polymorphic and arborizing vessels) followed by globule-like structures. ...

... The color of the lesion varies, ranging from skin-colored to bluish or pinkish. In addition, the presence of a central hair follicle orifice or punctum may also be visible (1,2). Microcystic adnexal carcinoma (MAC) is a malignant adnexal tumor that was first described in 1982 by Goldstein et al. ...

... It may clinically manifest itself with the appearance of a swelling, sometimes with discharge, ulceration, or retraction of the nipple. Positive diagnosis is based on histology and the classification systems are the same as in females [2]. Case reports have shown that it may also rarely manifest with pigmented lesions suggestive of pigmented Paget's disease or mimicking cutaneous neoplasms, such as melanoma or basal cell carcinoma, with similar dermoscopic findings [1]. ...