Masanori Shimodaira's research while affiliated with Takara Bio and other places

Publications (43)

Article
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Background/objectives: It has been unknown if attenuated insulin sensitivity (Si) in non-alcoholic fatty liver disease (NAFLD) is a cause or a result. We examined the impact of attenuated Si on NAFLD evolution. Subjects/methods: We observed 4856 NAFLD- and diabetes-free participants for a mean 2.9 years. Si was indexed by single point insulin se...
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Purpose We aimed to clarify the onset of diabetes. Methods Data from 27,392 non-diabetic health examinees was retrospectively analyzed for a mean of 5.3 years. Trajectories of fasting plasma glucose (FPG), body mass index (BMI) and the single point insulin sensitivity estimator (SPISE), an index of insulin sensitivity (Si), 10 years prior to diagn...
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Background Epidemiology studies have revealed that patients with obesity, hyperglycemia, or hypertension are associated with a decreased urine pH. These metabolic disorders are related to insulin resistance; however, the association between urine pH and insulin resistance remains unclear. Methods To evaluate this association while controlling for c...
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Background Many studies have reported the association between body mass index (BMI) and fasting lipid profiles in children. However, little information exists about the screening of dyslipidemia in the non-fasted state. This study assessed whether BMI can predict non-fasting lipid abnormalities in children. Methods Using gender-separated analysis,...
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Objective: To investigate the relationship between urine pH and metabolic syndrome (MetS) and its components while controlling for covariates. Subjects and methods: This cross-sectional study was conducted on 5,430 Japanese subjects (4691 without MetS; 739 with MetS) undergoing health assessments. Partial correlation analysis and analysis of cov...
Article
Background: Reduced serum phosphorus (SP) levels are reported to be associated with insulin resistance and metabolic syndrome (MetS). However, there have been a few gender-specific studies although SP levels are substantially different between men and women. Methods: This is a cross-sectional study. A total of 16,041 subjects (9,076 men and 6,96...
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A hypothesis that postchallenge hyperglycemia in subjects with low body weight (BW) may be in part due to small glucose volume (Gv) was tested. We studied 11,411 non-diabetic subjects with a mean BW of 63.3 kg. 5,282 of them were followed for a mean of 5.3 years. In another group of 1,537 non-diabetic subjects, insulin sensitivity, secretion, and a...
Article
The adrenomedullin receptor is a complex molecule that comprises the calcitonin-receptor-like receptor (CRLR) and the receptor-activity-modifying protein (RAMP). RAMP1 is a vasodilation factor, and RAMP1-deficient mice (RAMP1(-/-)) exhibit inflammatory responses with a significant transient increase in serum calcitonin-gene-related peptide levels a...
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Aims Recent biological and epidemiological studies have found that insulin resistance is linked to iron overload. However, little is known about the association between hemoglobin and/or serum iron levels and pancreatic β-cell function. In this gender-separated cross-sectional study, we aimed to investigate the association of hemoglobin and serum i...
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Aims: To investigated the association between the ABO blood group and gestational diabetes mellitus (GDM). Materials and methods: A retrospective case-control study was conducted using data from 5424 Japanese pregnancies. GDM screening was performed in the first trimester using a casual blood glucose test and in the second trimester using a 50-g...
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The aim of this study was to evaluate the utility of hemoglobin A1c (HbA1c) to identify individuals with diabetes and prediabetes in the Japanese population. A total of 1372 individuals without known diabetes were selected for this study. A 75 g oral glucose tolerance test (OGTT) was used to diagnose diabetes and prediabetes. The ability of HbA1c t...
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Blood pressure and lipid profile are important determinants of cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). To identify the pleiotropic effects of vildagliptin other than blood glucose lowering effect, a retrospective study was conducted in 128 patients with T2DM treated with vildagliptin 50 mg twice daily. The patients wer...
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Adult-onset Still's disease is a rare inflammatory condition of unknown origin characterized by high spiking fever, arthralgia, arthritis, myalgia, salmon-colored evanescent rash, and hepatosplenomegaly. The diagnosis of adult-onset Still's disease requires the exclusion of other possible disorders because it lacks specific clinical and histopathol...
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Carbohydrate antigen (CA) 19-9 is used as a clinical tumor marker of pancreatic cancer; recent studies report that CA 19-9 is also associated with changes in blood glucose levels. The aim of the present study was to investigate the relationship between serum CA 19-9 levels and early-phase insulin secretion in nondiabetic individuals. We enrolled 26...
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Introduction: Type 2 diabetes mellitus (T2DM) is linked to altered calcium metabolism. However, little is known about the relationship between serum calcium levels and early-phase insulin secretion in subjects with normoglycemic tolerance (NGT) or prediabetes (preDM). Methods: In this gender-separated cross-sectional study, 352 subjects with NGT (2...
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High serum uric acid (UA) levels are believed to be an independent risk factor for the development of diabetes. We aimed to investigate the relationship between serum UA concentrations and early-phase insulin secretion following a 75 g oral glucose tolerance test (OGTT) in nondiabetic subjects. We enrolled 570 Japanese subjects (354 males and 216 f...
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Background Increased triglycerides (TGs) and decreased high density lipoprotein cholesterol (HDL-C) levels are established as diabetic risks for nondiabetic subjects. The aim of this study was to investigate the relationship among TG, HDL-C, TG/HDL-C ratio, and early-phase insulin secretion in normoglycemic and prediabetic subjects. Methods We eva...
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Background/aims: Increased triglyceride (TG) and decreased high-density lipoprotein cholesterol (HDL-C) levels are considered risk factors for diabetes among prediabetic subjects. In this study, we retrospectively investigated the relationship between lipid profiles and the rate of change in early-phase insulin secretion in prediabetic subjects....
Article
Objective: The diagnosis of pheochromocytoma in patients receiving levodopa is challenging because the standard diagnostic biochemical tests may be confounded by dopaminergic therapy. We aim to showcase our experience with the diagnosis of pheochromocytoma in a patient with a known case of Parkinson's disease who was receiving levodopa. Methods:...
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Aims/Introduction Mean platelet volume (MPV) reflects platelet activity, and high MPV is associated with thrombogenic activation and increased cardiovascular disease risk. Although a positive correlation between MPV and fasting plasma glucose (FPG) levels has been reported, the correlation between MPV and postprandial glucose levels remains unclear...
Article
Abstract Mean platelet volume (MPV) can reflect platelet activity. Furthermore, high MPV is associated with thrombogenic activation and increased risk of cardiovascular disease. MPV of subjects with hypertension, hyperglycemia, or hyperlipidemia is higher compared with that of normal subjects. In contrast, the relationship between MPV and uric acid...
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Objective: To determine whether polymorphisms of the maternal glucocorticoid-related genes (HSD11B1 and HSD11B2) are associated with pregnancy-induced hypertension (PIH) in a haplotype-based case-control study. Methods: A total of 166 PIH patients and 222 age-matched controls were genotyped, with two single-nucleotide polymorphisms (SNPs) for th...
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Background: Short-term intensive insulin therapy (IIT) in patients with Type 2 diabetes mellitus (T2DM) has beneficial effects on insulin secretion. However, IIT effect on glucagon and glucagon-like peptide-1 (GLP-1) secretion is unknown. Aim: We evaluated short-term intensive glycemic control effects on insulin, glucagon, and GLP-1 secretory dy...
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A 44 year-old female patient visited our department for the treatment of diabetes. Her diabetes was pointed out 1 year before and was resistant to the treatment with oral hypoglycemic agents. From around the same time, she complained of repeated attacks consist of headache, palpitation, sweating and nausea. She had suffered from obsessive compulsiv...
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Introduction: Brugade syndrome (BS) is a cardiac disorder characterized by typical electrocardiograph (ECG) alterations and is known to have a high risk of sudden cardiac death (SCD). Isolated ACTH deficiency (IAD) is often associated with fetal arrhythmia. Previous reports have suggested that certain endocrine diseases might cause Brugada-like ECG...
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Background Abdominal wall hematomas are an uncommon cause of acute abdominal pain and are often misdiagnosed. They are more common in elderly individuals, particularly in those under anticoagulant therapy. Most abdominal wall hematomas occur in the rectus sheath, and hematomas within the oblique muscle are very rare and are poorly described in the...
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Background Prediabetes is an independent risk factor for cardiovascular diseases. Mean platelet volume (MPV) can reflect platelet activity, and high MPV is associated with thrombogenic activation and an increased risk of cardiovascular disease. In diabetic patients, MPV is higher when compared with normal subjects. However, the relationship between...
Article
One-hour plasma glucose (1-h PG) level of ≥ 155 mg/dL during an oral glucose tolerance test (OGTT) predicts the development of type 2 diabetes mellitus among individuals with normal glucose tolerance (NGT). In addition, high triglyceride (TG) and low high-density lipoprotein-cholesterol (HDL-C) levels are risks factors for development of diabetes m...
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Smoothelin is a specific type of cytoskeletal protein found in smooth muscle cells (SMCs). Several previous research studies have examined the relationship between smoothelin and atherosclerotic plaque. The aim of the present study was to further assess the association between the human SMTN gene and cerebral infarction (CI) using a haplotype-based...
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Smoothelin is a specific cytoskeletal protein that is associated with smooth muscle cells. The human SMTN gene encodes smoothelin-A and smoothelin-B, and studies using SMTN gene knockout mice have demonstrated that these animals develop hypertension. The aim of the present study was to investigate the association between the human SMTN gene and ess...
Article
Objectives: Smoothelin is a specific kind of cytoskeletal protein present in smooth muscle cells. Some researchers have shown the relationship between smoothelin and atherosclerotic plaque. The human SMTN gene encodes smoothelin-A and smoothelin-B. The aim of the present study was to assess the association between the human SMTN gene and myocardia...
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Hypertension in pregnancy is a multifactorial disorder caused by a complex combination of environmental factors and several predisposing genes. Since estrogen modulates placental vascular development, estrogen synthases are considered plausible candidate genes. The aim of this haplotype-based case-control study was to estimate whether polymorphisms...
Article
SLC6A18 (solute carrier family 6, member 18) acts as a specific transporter for neurotransmitters, amino acids and osmolytes such as betaine, taurine and creatine. The aim of the present study was to investigate the relationship between the human SLC6A18 gene and myocardial infarction (MI) in a Japanese population. Using 5 single nucleotide polymor...
Article
HSD3B1 and HSD3B2 are crucial enzymes for the synthesis of hormonal steroids, including aldosterone. Therefore, HSD3B gene variations could possibly influence blood pressure (BP) by affecting the aldosterone level. We performed a haplotype- and diplotype-based case-control study to investigate the association between the HSD3B gene variations and e...
Article
Elastin microfibril interfacer 1 (EMILIN-1) is a negative regulator of the transforming growth factor-beta (TGF-beta) signaling, which is involved in blood pressure (BP) homeostasis. Emilin1 knockout mice display elevated BP. The aim of the present study was to assess the association between the human EMILIN1 gene and essential hypertension (EH) us...
Article
Oxidative DNA damage is involved in the pathophysiology of essential hypertension (EH), which is a multifactorial disorder. Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/REF-1) is an essential endonuclease in the base excision repair pathway of oxidatively damaged DNA, in addition to having reducing properties that promote the...
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As aromatase-deficient mice, which are deficient in estrogens, reportedly have reduced blood pressure, the aromatase gene (CYP19A1) is thought to be a susceptibility gene for essential hypertension (EH). The aim of the present study was to investigate the relationship between CYP19A1 and EH by examining single nucleotide polymorphisms (SNPs). Five...

Citations

... Among these, the SPISE was developed as an easy and affordable tool for the evaluation of whole-body insulin sensitivity, which is comparable to clamp-derived M-value in sensitivity as well as specificity (19). Several studies have evaluated the SPISE in adult as well as juvenile populations (20,(41)(42)(43)(44)(45)(46). Correa-Burrows et al. assessed SPISE for its validity in diagnosing cardiometabolic risks, namely IR and metabolic syndrome, in post-pubertal Hispanic adolescents. ...
... Moreover, it has been reported that higher fasting plasma glucose levels can be observed at least 10 years before the diagnosis of T2DM. 191 Although migraine has been associated with some factors implicated in diabetes, such as obesity and insulin resistance, to date little is known about the relationship between migraine and T2DM. Interestingly, Fagherazzi et al. recently reported 59 a linear decrease in the prevalence of migraine during the 24 years prior to T2DM diagnosis. ...
... It has been shown that U-pH is inversely correlated with body weight and body mass index (BMI) [10][11][12] . A low level of U-pH has also been reported to be associated with metabolic disorders such as metabolic syndrome 13,14 , insulin resistance 15,16 , impaired glucose tolerance 17 , DM 18 and nonalcoholic fatty liver disease 19,20 . In a longitudinal analysis, a low level of U-pH was shown to be a risk factor for new onset of metabolic syndrome in a 5-year period 21 . ...
... We also observed that an increased pH increased the chance of classifying participants into a trained group. A lower urine pH was associated with chronic kidney disease [70], chronic heart failure [71] and metabolic syndrome [69,72,73]. ...
... Similarly, a cross-sectional study on 1701 healthy patients reported an inverse association between serum phosphate and HOMA-IR [11]. Furthermore, a growing body of evidence suggests an inverse association between phosphate levels and risk of MetS [29] [30]. ...
... Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated, as reported in the original study: (FPG × fasting immunoreactive insulin)/405, where the units of measurement are mg/dL for FPG and μU/mL for immunoreactive insulin [14]. Then, the reciprocal of HOMA-IR, 1/HOMA-IR, was adopted as the reference for Si [15], 1/HOMA-IR and SPISE were compared in 1537 non-diabetic health examinees at Iida Municipal Hospital (sex ratio 950:587, mean age 52.8 years), whose characteristics are shown in Supplemental Table 1 [16]. ...
... 29 Rs3754701 has also been shown to be associated with cerebral infarction and essential hypertension through haplotype analysis in Japan. 30,31 Similarly, the SNP rs7590387 located 1.4 kb downstream of the RAMP1 gene was found to be associated with cerebral infarction and transformation of migraine into medical overuse headache in an Italian study. 30,32 In addition, rs3754701 has been reported to be linked to a change in RAMP1 expression in whole blood on the GTEx portal website (www.gtexportal.org). ...
... Было подтверждено, что уровень гемоглобина положительно связан с инсулинорезистентностью, и с нарушением секреции инсулина первой и второй фаз и отрицательно с эффективностью глюкозы, а наиболее тесно связана со значениями гемоглобина инсулинорезистентность. Также согласно исследованиям, повышенный уровень гематокрита и вязкости крови ассоциирован с инсулинорезистентностью и является независимым предиктором сахарного диабета 2-го типа [16,17]. ...
... [10] In some studies, the ABO blood types were observed to be a protective factor for GDM; however, it was observed to be a risk factor in others, and some reports reported that there is no association between GDM and blood types. [11][12][13][14][15] GDM was screened using a single-step (75-g OGTT) or double-step (50-to 100-g OGTT) test at 24-28 weeks of gestation. For single step screening, the patients screened at 24-28 weeks of gestation using the single-step 75-g oral glucose tolerance test (OGTT) according to the criteria of the International Association of Diabetes and Pregnancy Study Group (IADPSG) were analyzed. ...
... Therefore, early detection of prediabetes and diabetes is crucial for appropriate management and prevention of disease progression [12,13]. According to the Australian Guidelines for Preventive Activities in General Practice [14], regular (within three years) diabetes screening is recommended for those with a clinical history of gestational diabetes mellitus or polycystic ovary syndrome (PCOS) and those treated with antipsychotics or at higher risk of cardiovascular disease (CVD). ...