Mary Pankau’s scientific contributions

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Publications (1)


Ageing and dealkylation of Soman (pinacolylmethylphosphonofluoridate)-inactivated eel cholinesterase
  • Article

August 1967

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25 Reads

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141 Citations

Archives of Biochemistry and Biophysics

Harry O. Michel

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Brennie E. Hackley

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Lewis Berkowitz

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[...]

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Mary Pankau

Ageing and dealkylation of Soman-inactivated electric eel cholinesterase occur at essentially identical rates and are catalyzed by an acidic group in the enzyme with a pKa′ of 6.4. Dealkylation of Soman-inactivated electric eel cholinesterase takes place by a carbonium ion mechanism with the production of 2,3-dimethyl-2-butanol; 2,3-dimethyl-1-butene; and 2,3-dimethyl-2-butene.

Citations (1)


... In some instances, depending on the structure of the nerve agent bound to AChE, dealkylation, i.e., leaving of alkoxy group from AChE-nerve agent phosphate occurs, resulting in a negatively charged dealkylated AChE-OP complex [2]. This process is called aging and therapeutic intervention by an oxime (pralidoxime or obidoxime) is only possible before the onset of this process [3]. Also, oximes are permanently positively charged which prevents them to cross blood-brain barrier, which means if applied on time, Depending of the bulkiness of alkoxy group of nerve agent, aging process occurs in different time interval. ...

Reference:

The design and synthesis of the four novel dual reversible inhibitors of acetylcholinesterase based on the tacrine and aroylacrylic acid phenylamide substructures
Ageing and dealkylation of Soman (pinacolylmethylphosphonofluoridate)-inactivated eel cholinesterase
  • Citing Article
  • August 1967

Archives of Biochemistry and Biophysics