Mary K. Dierks's research while affiliated with University of Arkansas and other places

Publications (2)

Article
Full-text available
Intraepithelial dysplasia of the oral mucosa typically originates in the proliferative cell layer at the basement membrane and extends to the upper epithelial layers as the disease progresses. Detection of malignancies typically occurs upon visual inspection by non-specialists at a late-stage. In this manuscript, we validate a quantitative hybrid i...
Article
Early detection of structural or functional changes in dysplastic epithelia may be crucial for improving long-term patient care. Recent work has explored myriad non-invasive or minimally invasive "optical biopsy" techniques for diagnosing early dysplasia, such as high-resolution microendoscopy, a method to resolve sub-cellular features of apical ep...

Citations

... Subsequently, the system was validated in the clinical environment and in vivo sub-DRS data were collected from the inner lip of 13 volunteers. This hybrid system was reported to be capable of gathering information on functional and structural properties of tissue [93]. ...
... Each DRS measurement resulted in a value for THC, StO 2 , HbO 2 , dHb (630 nm) [34], and a chi-square (χ 2 ) value. THC, StO 2 , HbO 2 , dHb were quantified by inputting raw DRS spectra into custom lookup-table (LUT)based MATLAB software with a priori values for oxygenated and deoxygenated hemoglobin extinction coefficients [35][36][37]. The software performed an iterative model fit (1 × 10 4 iterations) to the raw DRS data to quantify THC, StO 2 , HbO 2 , dHb. ...