Martin Malawer’s research while affiliated with Georgetown University and other places

... Due to their rarity and heterogeneous nature, sarcomas present significant diagnostic and therapeutic challenges [2]. Surgical resection remains the cornerstone of sarcoma management, with the success of surgical outcomes heavily influenced by tumor characteristics such as size, grade, and anatomical location [3]. ...

Reference:

Planned and Unplanned Sarcoma Resections: Comparative Analysis of Local Recurrence, Metastasis, and Mortality

... Non-neoplastic conditions may also require such procedure for reconstruction for segmental proximal femoral bone loss. 1 These include complications of total hip arthroplasty including periprosthetic fracture, aseptic loosening, osteolysis, chronic infection, stress shielding, metabolic bone disease, and failed conventional treatment of proximal femoral fracture. 2 Periprosthetic fracture around a femoral stem is the third most common reason for reoperation following total hip replacement. 3 Regardless of the indication, the challenges of such treatment are loss of considerable bone lengths, loss of important soft tissue attachments, instability of the joint, and alternation in the normal function of the hip. 4 The goals of hip revision surgery are to create a stable construct, preserve bone and soft tissues, augment deficient host bone, improve function, provide a foundation for future surgery, and create a biomechanically restored hip. 5 Current options for treatment of severe femoral defects include megaprosthesis replacement, allograft prosthetic composite (APC), and resection arthroplasty. ...

Reference:

Proximal Femoral Reconstruction in Hip Arthroplasty

... Dirsek poplitea gibi kıvrımlarda , transvers/oblik segmente sahip long insizyon kullanılabilir. [40] Biopsinin yapılabildiği , mümkün olan uzunluğu en kısa insizyon kullanılmalıdır. İnsizyon traktı ne kadar büyürse kontamine doku ve nihai operasyonda çıkarılması gereken doku o kadar fazla olur. ...

Reference:

Kemik ve yumuşak doku tümörleri

... The debilitating pain and the loss of functional activities that follow despite nonsurgical management or interventional procedures like percutaneous cementoplasty and radiofrequency or cryoablation are indications for surgical management [1,10]. Because both metastatic tumors and multiple myeloma are mostly sensitive to radiation therapy, these do not necessitate an en bloc removal but rather an intralesional approach in addition to adjuvant radiation therapy for addressing residual disease [2,16]. ...

Reference:

Joint-sparing Reconstruction for Extensive Periacetabular Metastases: Literature Review and a Novel Minimally Invasive Surgical Technique

... Adequate contact of the tumor margin is important to ensure the delivery of extreme temperature that destroy the malignant cell [19,25]. Previous study has shown that inadequate freezing may predispose to local recurrence of bone tumor [20,22]. The duration of freezing in the liquid nitrogen, in this case, is longer than in the previous study, with 40 min of freezing compared to 20 min [16]. ...

Reference:

Cryosurgery and vascularized fibular graft reconstruction in proximal tibia osteosarcoma in young children: A case report

... Since the 1970s, advances in chemotherapy and radiotherapy have spurred the development of surgical techniques aimed at limb preservation and reconstruction [5]. Traditionally, large bone tumors causing significant bone destruction required wide resection and joint fusion or amputation. ...

Reference:

MODULAR HINGED LONG-STEM KNEE ENDOPROSTHESIS (MEGAPROSTHESIS) IN THE TREATMENT OF LEFT PROXIMAL TIBIAL GIANT CELL TUMOR: A CASE REPORT AND LITTERATURE REVIEW

... We used standard surgical resection techniques for tumors of the distal femur and the proximal tibia with the implementation of wide surgical margins. 6,29,30 Tumor bearing autograft was extracororeally debrided and recycled by freezing using liquid nitrogen and reimplanted using a hinged constrained knee prosthesis. Soft-tissue coverage and reconstruction were performed after completion of the reconstruction. ...

Reference:

Knee joint reconstruction using liquid nitrogen recycled autograft prosthesis composite after wide resection for high-grade chondrosarcoma

... amputation surgeries, being the safest and valid solution at that time, and, in this sense, the orthopaedics pioneers developed various techniques in this regard which unfortunately failed [4]. ...

Reference:

RESEARCHING AND TRENDS IN OPTIMIZING HIP JOINT PROSTHESIS

... Segmental prosthesis has several advantages including a shorter required hospital stay, early mobilization and the ability to tolerate chemotherapy and radiotherapy [8]. However, the usage of segmental prosthesis is declining due to high complication rates involving mechanical failure and aseptic loosening [5,[9][10][11]. Therefore, we excluded studies concerning segmental prosthetic replacement in this study, and focused on intramedullary nail fixation (INF) and plate fixation (PF). INF and PF are commonly applied strategies in the treatment for PHSF nowadays. ...

Reference:

Intramedullary Nail vs. Plate Fixation for Pathological Humeral Shaft Fracture: An Updated Narrative Review and Meta-Analysis of Surgery-Related Factors

... 6 It was found to adapt and function in phase with the remaining quadriceps muscles because of its common origin of innervation from the femoral nerve. 23 This finding supports its use as a donor for quadriceps reinnervation and in many ways facilitates the donor activation-focused rehabilitation after the nerve transfer. 18 Potentially due to its more proximal and superficial branching location, sartorius branches are often spared in partial femoral nerve injuries. ...

Reference:

Femoral nerve decompression and sartorius-to-quadriceps nerve transfers for partial femoral nerve injury: a cadaveric study and early case series