Martin Krov's research while affiliated with Uni Chem and other places

Publications (2)

Article
Encapsulation of active compounds into liquid marbles (LMs) represents an emerging technology with potential applications in several fields including food, cosmetics and pharmaceutics. However, existing methods for the preparation of LMs are either based on manual one-by-one fabrication or on batch processes such as high-shear granulation, which la...
Article
Abiraterone acetate has limited bioavailability in the fasted state and exhibits a strong positive food effect. We present a novel formulation concept based on the so-called oil marbles (OMs) and show by in vitro and in vivo experiments that the food effect can be suppressed. OMs are spherical particles with a core-shell structure, formed by coatin...

Citations

... 5 Abiraterone acetate is a Biopharmaceutics Classification System class IV compound, with an extremely low oral bioavailability when administered in the fasted state. 6 However, the administration of abiraterone acetate with highfat food results in up to a 10-fold increased area under the concentration-time curve (AUC) and up to a 17-fold increase in the maximum plasma concentration (C max ) of abiraterone. 7 Because of the low oral bioavailability and significant food effect of abiraterone acetate, its administration carries a risk of toxicity and inaccurate dosing. ...