Marques A. Wilson's research while affiliated with U.S. Army Research Institute of Environmental Medicine and other places

Publications (37)

Article
Post-transcriptional regulation by microRNA (miRNA) facilitates exercise and diet-induced skeletal muscle adaptations. However, the impact of diet on miRNA expression during post-exercise recovery remains unclear. The objective of this study was to examine the effects of consuming carbohydrate or a nutrient free control on skeletal muscle miRNA exp...
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Background Physiological and psychological stress slow healing from experimental wounds by impairing immune function. Objective To determine whether supplemental protein and multi-nutrient supplementation improve wound healing markers following acute stress induced by acute sleep restriction. Methods In this single-blind, cross-over study of gene...
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Background The effects of ingesting varying essential amino acid (EAA)/protein-containing food formats on protein kinetics during energy deficit are undetermined. Therefore, recommendations for EAA/protein food formats necessary to optimize both whole-body protein balance and muscle protein synthesis (MPS) during energy deficit are unknown. We meas...
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Background The effects of low muscle glycogen on molecular markers of protein synthesis and myogenesis before and during aerobic exercise with carbohydrate ingestion is unclear. The purpose of this study was to determine the effects of initiating aerobic exercise with low muscle glycogen on mTORC1 signaling and markers of myogenesis. Methods Eleve...
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This study used global metabolomics to identify metabolic factors that might contribute to muscle anabolic resistance, which develops when aerobic exercise is initiated with low muscle glycogen using global metabolomics. Eleven men completed this randomized, crossover study, completing two cycle ergometry glycogen depletion trials, followed by 24 h...
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Hypoxia-induced insulin resistance appears to suppress exogenous glucose oxidation during metabolically-matched aerobic exercise during acute (<8-h) high-altitude (HA) exposure. However, a better understanding of this metabolic dysregulation is needed to identify interventions to mitigate these effects. The objective of this study was to determine...
Article
Objective Several nights of moderate (4-5 hr/night) sleep restriction increases appetite and energy intake, and may alter circulating concentrations of appetite regulating hormones. Whether more severe sleep restriction has similar effects is unclear. This study aimed to determine the effects of severe, short-term sleep restriction on appetite, ad...
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Background: The ergogenic effects of supplemental carbohydrate on aerobic exercise performance at high altitude (HA) may be modulated by acclimatization status. Longitudinal evaluation of potential performance benefits of carbohydrate supplementation in the same volunteers before and after acclimatization to HA have not been reported. Purpose: T...
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Background Strenuous physical activity promotes inflammation and depletes muscle glycogen, which may increase the iron regulatory hormone hepcidin. Hepcidin reduces dietary iron absorption and may contribute to declines in iron status frequently observed following strenuous physical activity. Objectives To determine the effects of strenuous physic...
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Background & aims Consuming 0.10-0.14 g essential amino acids (EAA)/kg/dose (0.25-0.30 g protein/kg/dose) maximally stimulates muscle protein synthesis (MPS) during energy balance. Whether consuming EAA beyond that amount enhances MPS and whole-body anabolism following energy deficit is unknown. The aims of this study were to determine the effects...
Article
Objectives Acute bouts of sleep restriction (SR) are unavoidable in certain populations (e.g., military personnel and first responders), and impairs immune function as evidenced by delays in skin barrier recovery of experimental wounds by ∼1 day. To what extent this impairment can be mitigated by nutritional supplementation is less clear. We tested...
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Objectives Maintaining low muscle glycogen content during recovery from aerobic exercise with low carbohydrate, high fat feeding has been shown to reduce insulin-mediated anabolic signaling compared to high carbohydrate feeding. The effects of low muscle glycogen content on intracellular regulators of muscle mass before and after aerobic exercise w...
Article
Objectives Several nights of moderate (4–5 hr/night) sleep restriction increases appetite and energy intake, and may alter circulating concentrations of food intake-regulating hormones. Whether more severe sleep restriction has similar effects is undetermined. This study aimed to determine the effects of severe, short-term sleep restriction on appe...
Article
Background: Exogenous carbohydrate oxidation is lower during steady-state aerobic exercise in native lowlanders sojourning at high altitude (HA) compared to sea level (SL). However, the underlying mechanism contributing to reduction in exogenous carbohydrate oxidation during steady-state aerobic exercise performed at HA have not been explored. Ob...
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Purpose The objective of the study was to evaluate how controlled, short-term sleep restriction (SR; 72 h) alters markers of bone formation and resorption and urinary calcium (Ca) output. Methods Ten healthy, sleep-adequate, male soldiers were housed in the research facility one day prior to and for the duration of SR. Diet was controlled to provi...
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Objectives Lowlanders performing steady-state aerobic exercise during high-altitude (HA) sojourns, hypoxia mediates increased endogenous carbohydrate oxidation compared to sea level (SL). At SL, ingesting carbohydrate during exercise spares endogenous carbohydrate stores and improves endurance. However, it is unclear whether that strategy is effect...
Article
Consumption of certain berries appears to slow postprandial glucose absorption, attributable to polyphenols, which may benefit exercise and cognition, reduce appetite and/or oxidative stress. This randomised, crossover, placebo-controlled study determined whether polyphenol-rich fruits added to carbohydrate-based foods produce a dose-dependent mode...
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BACKGROUND: Initiating aerobic exercise with low muscle glycogen content promotes greater fat and less endogenous carbohydrate oxidation during exercise. However, the extent exogenous carbohydrate oxidation increases when exercise is initiated with low muscle glycogen is unclear. PURPOSE: Determine the effects of muscle glycogen content at the on...
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This study investigated how high-altitude (HA, 4300 m) acclimatization affected exogenous glucose oxidation during aerobic exercise. Sea-level (SL) residents (n = 14 men) performed 80-min, metabolically matched exercise ( V ˙ O2 ∼ 1.7 L/min) at SL and at HA < 5 h after arrival (acute HA, AHA) and following 22-d of HA acclimatization (chronic HA,...
Article
Systemic immune function is impaired by sleep restriction. However, the impact of sleep restriction on local immune responses, and to what extent any impairment can be mitigated by nutritional supplementation is unknown. We assessed the effect of 72-h sleep restriction (2-h nightly sleep) on local immune function and skin barrier restoration of an...
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Background: In studies assessing the effects of acute undernutrition on cognitive function, volunteers are sedentary and findings are equivocal, even though glucose concentrations fall substantially. However, military personnel and endurance athletes often are underfed when physical demands, and consequently energy expenditure, are substantial. O...
Article
Purpose: To characterize the glycemic response to acute, severe energy deficit compared to fully fed control condition, using continuous glucose monitoring (CGM). Methods: For 2 days during a double-blind, placebo-controlled, crossover study, 23 volunteers (17M/6F; age: 21.3±3.0 years; BMI: 25±3 kg/m(2)) increased habitual daily EE ([mean±SD] 23...
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Background Military personnel frequently endure intermittent periods of severe energy deficit which can compromise health and performance. Physiologic factors contributing to underconsumption, and the subsequent drive to overeat, are not fully characterized. This study aimed to identify associations between appetite, metabolic homeostasis and endoc...
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Full-text available
Development of n-3 fortified, shelf-stable foods is facilitated by encapsulated docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), since natural n-3 food sources cannot withstand high temperature and prolonged shelf life. Organoleptic stability of n-3 fortified, shelf-stable foods has been demonstrated, but chemical changes in the food mat...
Article
Skin wound healing models can be used to detect changes in immune function in response to interventions. This study used a test-retest format to assess the reliability of a skin suction blister procedure for quantitatively evaluating human immune function in repeated measures type studies. Up to eight suction blisters (~30 mm(2)) were induced via s...

Citations

... Proteins are important nutrients for the proliferation and remodelling of wound healing (Cheng et al., 2020;Smith et al., 2022). Proteins can promote the formation of capillaries, the proliferation of fibroblasts and the synthesis of collagen and improve the function of the immune system. ...
... Muscle protein occurs when the aerobics formation starts with low muscle glycogen levels. is work employed global biological methods to uncover metabolic variables in BD that may contribute to this condition [13]. ...
... Aerobic exercise AF with low glycogen leads to molecular changes that promote enhanced fat oxidation. Aerobics has a rigid teaching method AF that cannot keep up with the times [2]. Aerobic formation on transformation route simulation research tests has been developed due to a desire to make fitness testing in a team-sport situation more accessible and more cost-effective. ...
... Various untargeted metabolomics approaches have been used in human studies to identify unique biochemical responses to prolonged steady-state exercise, physically demanding training programs, caloric restriction, and extreme environments (Blackburn et al., 2020, Howe et al., 2018, Karl et al., 2017, Miyata et al., 2021, Margolis et al., 2021. These studies, which may have induced an energy deficit to some degree, found perturbations in metabolomic signatures that included increased free fatty acids, acylcarnitines, omega-fatty acid intermediates, and amino acids (Blackburn et al., 2020, Howe et al., 2018, Karl et al., 2017. ...
... Even in healthy adults, acute (one day) to short-term (several days) partial or total sleep deprivation yields impairments in glucose tolerance and insulin sensitivity (Buxton et al. 2010;Donga et al. 2010;González-Ortiz et al. 2000;Nedeltcheva et al. 2009;Reynolds et al. 2012), appetite regulation (Radcliffe et al. 2021;Schmid et al. 2008;Spiegel et al. 2004;St-Onge et al. 2012), and impaired peripheral vascular function, inclusive of arterial stiffness and endothelial function (Calvin et al. 2014;Grassi et al. 2016;Sauvet et al. 2017Sauvet et al. , 2015Sunbul et al. 2014). However, one of the limitations to these sleep restriction paradigms is that they may not translate to real-world settings where people frequently experience inadequate sleep duration (i.e., < 7-hours), but infrequently engage in partial (e.g., < 4-hours) or complete sleep deprivation (Cherubini et al. 2021;Spiegel et al. 2005). ...
... Skeletal muscle sensitivity to anabolic capability is diminished in favor of whole-body protein homeostasis during caloric deficit [77,78]. For example, diet-induced energy deficits of 30% revealed that an EAA dose of 0.3 g/kg maintained whole-body protein balance and stimulated muscle protein synthesis, while a lower dose of 0.1 g/kg was only able to maintain protein balance [78]. ...
... Research has sought to determine the effects of exercise on iron regulation in athletes in order to determine appropriate interventions to treat and manage ID in this population. Accordingly, several studies have described the influence of endurance exercise on hepcidin regulation in both the short-and long-term (Karl et al. 2010;Auersperger et al. 2012Auersperger et al. , 2013McClung et al. 2013;Sim et al. 2014;Ishibashi et al. 2017;Moretti et al. 2018;Larsuphrom and Latunde-Dada 2021;Hennigar et al. 2021). In the short term, exercise markedly increases hepcidin, reaching a peak at 3 h postexercise. ...
... Skeletal muscle sensitivity to anabolic capability is diminished in favor of whole-body protein homeostasis during caloric deficit [77,78]. For example, diet-induced energy deficits of 30% revealed that an EAA dose of 0.3 g/kg maintained whole-body protein balance and stimulated muscle protein synthesis, while a lower dose of 0.1 g/kg was only able to maintain protein balance [78]. ...
... However, these each have limited effectiveness or present notable side effects: acute altitude descension may not be logistically feasible; acetazolamide has been demonstrated to reduce both cognitive and physical performance, accrue side effects, and does not increase muscle oxygenation [285,287]; erythropoietin may only provide ergogenic effects up to 3500 m [289]; intravenous iron infusion may not be feasible for all individuals [290]; and sildenafil can exaggerate symptoms of mountain sickness including headaches [288]. An increased reliance on, or preference for, CHO for energy provision in hypoxic environments such as moderate-to-high altitude is hypothesised [291], but CHO ingestion does not reliably augment performance at moderate-to-high altitude [292][293][294]. In fact, aerobic exercise performed during acute high altitude exposure elicited lower exogenous glucose oxidation, glucose turnover, and glucose disposal, while concomitant increases in circulating [glucose] and [insulin] suggested a reduced sensitivity of skeletal muscle to glucose uptake in hypoxia compared with exercise in normoxia [295]. ...
... An increased reliance on, or preference for, CHO for energy provision in hypoxic environments such as moderate-to-high altitude is hypothesised [291], but CHO ingestion does not reliably augment performance at moderate-to-high altitude [292][293][294]. In fact, aerobic exercise performed during acute high altitude exposure elicited lower exogenous glucose oxidation, glucose turnover, and glucose disposal, while concomitant increases in circulating [glucose] and [insulin] suggested a reduced sensitivity of skeletal muscle to glucose uptake in hypoxia compared with exercise in normoxia [295]. Taken together, alternative fuelling strategies that attenuate declines in systemic and skeletal muscle oxygenation, exercise performance, and symptoms of mountain sickness may provide ergogenic benefit during moderate-to-high altitude exposure. ...