Mark Webster’s research while affiliated with Auckland City Hospital and other places

... Subsequently, 328 studies were assessed for full-text screening and eligibility, and 18 studies were included in our meta-analysis ( Figure 1). These studies, from 10 RCTs, comprised a total of 4325 patients undergoing TAVR (2295 BEV, 2030 SEV) [13,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. The complete characteristics of the included studies are available in Table 1 and Supporting Information S1: Table S4. ...

Reference:

Short‐Term, Mid‐Term, and Long‐Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon‐Expandable Versus Self‐Expanding Valves: A Meta‐Analysis of Randomized Controlled Trials

... The ProtEmbo device uses a heparin-coated mesh to capture debris, while Emboliner is designed for full-body embolic protection, capturing debris from both the cerebral and peripheral circulation. Early studies with these devices have shown promising results in terms of debris capture, but their impact on stroke prevention remains to be fully determined [21,22]. ...

Reference:

2024 Update on Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement

... There is thus 'uncaging' despite the persistent presence of scaffolding metallic helical strands. There is now data from two large RCTs showing superior clinical outcomes compared to conventional DES, and even a possible plateau in device related adverse events from 6 months onward [11,12]. Should these benefits be confirmed over time, and across more complex patient and lesion subsets, the bioadaptor could offer a solution to flatten the event curve for patients treated with permanent metallic stent implants. ...

Reference:

Drug-eluting resorbable coronary scaffolds: a review of recent advances

... Endpoints have been described in detail previously. 14 The primary endpoint is TLF at 12 months, defined as Articles a composite of cardiovascular death, TV-MI and clinically-driven TLR. Secondary endpoints include lesion success (% diameter stenosis after treatment of target lesion with percutaneous coronary intervention, PCI, <30%), device success (% diameter stenosis after implantation of allocated study device <30%), and procedure success (lesion success without major adverse cardiac events during index hospitalisation). ...

Reference:

First randomised controlled trial comparing the sirolimus- eluting bioadaptor with the zotarolimus-eluting drug-eluting stent in patients with de novo coronary artery lesions: 12-month clinical and imaging data from the multi-centre, international, BIODAPTOR-RCT

... 8,25 While invasive diagnostic methods such as coronary angiography remain the gold standard, non-invasive diagnostic tools such as the models reviewed in this study have the potential to improve initial diagnosis in the emergency department and reduce unnecessary invasive procedures. 19 In addition, many models take into account comorbid conditions such as diabetes and psychiatric history, which are often associated with TTS. 1,24 This highlights the need for clinicians to take a holistic approach, assessing both mental and physical health to accurately assess risk. ...

Reference:

Diagnostic models to differentiate Takotsubo syndrome from acute coronary syndrome: A systematic review and meta‐analysis

... compared with the AMI group, the expression of TGF-β1, SMAD2, SMAD3 mRNA and protein in the rat of AMI+SIM-L, AMI+SIM-M and AMI+SIM-H groups significantly reduced (p>0.05) as shown in fig. 1 and Table 5. AMI is a very harmful disease to humans, which refers to the acute necrosis of part of the myocardium caused by long-lasting and severe myocardial ischemia, and in a short time, due to a certain reason, the human coronary artery has undergone occlusion, so that the human heart will be ischemic, causing a certain area of myocardial necrosis [8,9] . In this study, compared with the sham operation group, the LVW and LVWI of rats were significantly increased; SIM significantly reduced LVW and LVWI in rats compared with AMI group, compared with sham operation group, there were no significant changes in BW and lipid levels in rats of AMI group compared with those of sham operation group; compared with AMI group, SIM did not significantly affect the BW and lipid levels of rats. ...

Reference:

Effect of Simvastatin on Ventricular Remodeling in Rats with Acute Myocardial Infarction through Transforming Growth Factor-Beta/SMAD Signaling Pathway

... Notably, in that study COPD patients were not analyzed separately, potentially explaining discrepant results as compared with ours. The increase in long-term mortality of TTS patients with COPD that we observed can be largely explained by the pulmonary disease-related outcomes [33], in line with the mainly non-cardiovascular mortality of TTS after the acute phase reported in multiple cohorts [5,34,35]. Notwithstanding, a very recent study described the presence of an excess of cardiovascular mortality too [36], with non-cardiovascular events attributed to pulmonary causes in most of the cases. Interestingly, in our population we observed the overall pharmacological undertreatment of COPD patients, who less often received a beta-blocker or a RAS inhibitor at discharge, similarly to what described in general heart failure patient populations [37,38]. ...

Reference:

Clinical characteristics and outcomes of Takotsubo syndrome in patients with chronic obstructive pulmonary disease

... In cases of complex multi-vessel disease, complete revascularisation with coronary artery bypass grafting (CABG) is recommended (43). Supplemental oxygen is recommended in MI if the patient's oxygen saturation is less than 90% (65,66). Beta-blockers may be administered to lower heart rate and reduce myocardial oxygen demand, thereby lowering the risk of arrhythmias and adverse cardiac events (67). ...

Reference:

Management, prevention and outcome of myocardial infarction in native vs foreign-born patients

... The LANDMARK trial demonstrated the non-inferiority of the Myval transcatheter heart valve (THV) series compared to contemporary standard THVs (Sapien and Evolut series) with respect to the composite of safety and effectiveness endpoint at 30 days in patients with symptomatic severe aortic stenosis. [1][2][3] The primary results at 30 days were published in The Lancet in May 2024. ...

Reference:

LANDMARK trial: Update in statistical analytical plan and protocol for the 1-year report

... Previous studies have reported that SC patients were predominantly women, especially postmenopausal women, and an associated stressor was identified in most patients. Emotional triggers were more common than physical triggers (4,(14)(15)(16)(17)(18). However, the InterTAK Registry has reported that physical stimuli (including fracture, infection, disorders in central nervous system, acute respiratory failure, and stress after operation) were more commonly seen compared to emotional stimuli (including interpersonal conflict, anger anxiety, panic, fear, and grief), at 36.0% vs. 27.7%, ...

Reference:

Clinical characteristics and risk factors for death in patients with stress cardiomyopathy in the ICU