Mark Heffernan's research while affiliated with Monash University (Australia) and other places
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Publications (6)
Both human GH (hGH) and a lipolytic fragment (AOD9604) synthesized from its C-terminus are capable of inducing weight loss and increasing lipolytic sensitivity following long-term treatment in mice. One mechanism by which this may occur is through an interaction with the beta-adrenergic pathway, particularly with the beta(3)-adrenergic receptors (b...
Both human GH (hGH) and a lipolytic fragment (AOD9604) synthesized from its C-terminus are capable of inducing weight loss and increasing lipolytic sensitivity following longterm treatment in mice. One mechanism by which this may occur is through an interaction with the beta -adrenergic pathway, particularly with the beta (3)-adrenergic receptors (...
Previous studies from our laboratory have identified that a carboxy-terminal fragment of the human growth hormone (hGH), hGH(177–191), is the lipolytic/anti-lipogenic domain of intact hGH [1]. By targeting the key enzymes involved in lipid metabolism, hGH(177–191) is able to increase lipolysis, and decrease lipogenesis in adipose tissue, resulting...
A phytochemical preparation known as "Slimax" was administered orally to human volunteers for a six week period, using a double-blind experimental method. This preparation is an aqueous extract of the Chinese medicinal plants Hordeum vulgare , Polygonatum multiflorum , Dimocarpus longan , Ligusticum sinense , Lilium brownii and Zingiber officinale...
A phytochemical preparation known as “Slimax” was administered orally to human volunteers for a six week period, using a double-blind experimental method. This preparation is an aqueous extract of the Chinese medicinal plants Hordeum vulgare , Polygonatum multiflorum , Dimocarpus longan , Ligusticum sinense , Lilium brownii and Zingiber officinale...
C57BL/6J obese (ob/ob) and lean mice fed ad libitum on a normal mouse chow diet (Normal), were compared with lean mice of the same age and strain fed ad libitum on a high-fat diet, consisting of the Normal diet with the addition of beef lard (Lard), from age 3 months for 34 days. The lard-fed mice were seen to have significantly higher (P<0.05) bod...
Citations
... The lipolytic action of hGH 177–191 does not appear to be mediated by the same mechanism induced by the fulllength molecule (Rowlinson et al., 1996; Ng et al., 2000a, b; Heffernan et al., 2001). Another fragment of hGH (residues 96–133 ) also has lypoltic activity, but only 3% of the activity of the native molecule (Wieser et al., 1976). ...
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... Natural herbal or botanical formulas have shown clinically better weight-loss effects. In countries such as China [10,11], Japan [12,13], South Korea [14] and Australia [15,16], clinical trials of herbal or plant compounds for weight loss have been carried out with the population as the research object. All showed that the compound was both safe and effective. ...
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... We then sought to confirm the effects of endothelialcell-specific CNP overexpression in another obesity model. One of the most studied models in obesity research, ob/ob mice are genetically deficient in leptin 28 , which has a prominent role in the development of obesity 29 . In particular, ob/ ob mice display hyperphagia, obesity, hyperglycaemia, and insulin resistance 30 . ...
... 10 Chronic oral and injected dosing of LAT8881 has been shown to reduce body weight, affect lipolysis and lipogenesis in fat tissue of obese rodents. 8,[10][11][12] Intra-articular injection has also been shown to reduce inflammatory damage in a rabbit collagenase model of osteoarthritis, resulting in an accelerated repair of the affected joint. 13 Importantly, LAT8881 has been shown to have a promising profile in preclinical toxicology and in human safety studies. ...
