Mark Harbinson's research while affiliated with Queen's University Belfast and other places
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Publications (33)
Anthracycline chemotherapy is used in approximately two thirds of the 35,000 European children diagnosed with cancer each year. Unfortunately 1 in 10 will develop symptomatic heart failure at 40 years after therapy. Emerging evidence suggests that anthracyclines exert a significant cardiovascular insult that expands beyond an impaired ejection frac...
Introduction:
Radiation cardiotoxicity is a dose-limiting toxicity and major survivorship issue for patients with non-small cell lung cancer (NSCLC) completing curative-intent radiotherapy, however patients' cardiovascular baseline is not routinely optimised prior to treatment. In this study we examined the impact of statin therapy on overall surv...
Cancer and cardiovascular disease are two of the leading causes of global mortality and morbidity. Medical research has generated powerful lifesaving treatments for patients with cancer; however, such treatments may sometimes be at the expense of the patient's myocardium, leading to heart failure. Anti-cancer drugs, including anthracyclines, can re...
Background
Almost 60% of the 2,000 children diagnosed with cancer in the UK and Ireland every year are treated with anthracycline chemotherapy. Anthracyclines are WHO essential medicines, and 5-year childhood cancer survival rates are approaching 85%, but also carry a risk of cardiotoxicity, particularly for childhood cancer survivors (CCS) of whom...
Background
While cancer outcomes have improved over time, in Northern Ireland they continue to lag behind those of many other developed economies. The role of comorbid conditions has been suggested as a potential contributory factor in this but issues of data comparability across jurisdictions has inhibited efforts to explore relationships. We use...
Cancer therapeutics related cardiac dysfunction (CTRCD) has emerged as a major cause of morbidity and mortality in cancer survivors. Effective clinical management of CTRCD is impeded by a lack of sensitive diagnostic and prognostic strategies. Circulating molecular markers could potentially address this need as they are often indicative of cardiac...
Background
The coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known.
Objectives
This study sought to evaluate the effects of the early phase of the COVID-19 pandemic on cardiovascular diagn...
Impact of COVID-19 on Cardiovascular Testing in the United States Versus the Rest of the World
Objectives
This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.
Background
The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardi...
The subspecialty of cardio-oncology aims to reduce cardiovascular morbidity and mortality in patients with cancer or following cancer treatment. Cancer therapy can lead to a variety of cardiovascular complications, including left ventricular systolic dysfunction, pericardial disease, and valvular heart disease. Echocardiography is a key diagnostic...
The subspecialty of cardio-oncology aims to reduce cardiovascular morbidity and mortality in patients with cancer or following cancer treatment. Cancer therapy can lead to a variety of cardiovascular complications, including left ventricular systolic dysfunction, pericardial disease, and valvular heart disease. Echocardiography is a key diagnostic...
Background
Advances in cancer therapy have significantly improved long term survival rates of those with breast cancer. Concurrently, chemotherapy-induced cardiac dysfunction is receiving increased attention in breast cancer survivors. Reduced left ventricular systolic function related to cancer therapies has recently been designated cancer therape...
Introduction
Contrast induced acute kidney injury (CI-AKI), currently defined as a delta rise in serum creatinine of ≥26.5 µmol/litre or a relative rise of ≥50% from baseline measured at 48 hours following administration of iodinated contrast media, is reported to complicate almost 20% of studies in high-risk individuals1. As previously presented,...
Background/Introduction
Contrast induced acute kidney injury (CI-AKI), defined as a delta rise in creatinine of >26.5 µmol/L or a 50% relative rise within 48 hours following iodinated contrast, is associated with considerable mortality risk. Our previous study of 301 consecutive Chronic Kidney Disease (CKD) patients undergoing contrast coronary ang...
Introduction
Current guidelines regarding investigation and treatment of stable ischaemic heart disease are conflicting. The recently updated NICE guidelines advise CTCA for investigation of chest pain and reserve non-invasive ischaemia tests for patients with known coronary artery disease (figure 1). The ESC guidelines advise non-invasive ischaemi...
Introduction
Contrast induced acute kidney injury (CI-AKI), defined as a delta rise in creatinine of >26.5 umol/L or a 50% relative rise within 48 hours following iodinated contrast, is associated with considerable mortality risk. Our previous study of 301 patients undergoing contrast coronary angiography/percutaneous coronary intervention (PCI) hi...
Background:
Chronic Kidney Disease (CKD) is a risk factor for contrast induced acute kidney injury (CI-AKI). Contrast angiography in CKD patients is a common procedure. Creatinine is a delayed marker of CI-AKI and delays diagnosis which results in significant morbidity and mortality.
Aim:
Early diagnosis of CI-AKI requires validated novel biomar...
Introduction Chronic Kidney Disease (CKD) is a risk factor for contrast induced nephropathy (CIN), defined as an increase in serum creatinine of >25% from baseline or a delta rise of >26.5 µmol/L within 48 h. Early diagnosis of CIN requires validated novel biomarkers.
Methods A prospective observation study of 301 consecutive CKD patients undergoin...
Background Successful recanalisation of chronic total occlusion (CTO) is associated with improved mortality but a strong correlation with burden of ischaemia and symptoms is lacking. Myocardial perfusion reserve (MPR) by first-pass perfusion cardiac magnetic resonance imaging (CMR) is an accurate non-invasive measure of myocardial ischaemia. We eva...
Cardiovascular diseases (CVDs) are the principal cause of death in the world, (WHO database). Among CVDs, coronary artery diseases (CAD) are the most common diseases which are responsible for more than 38% of deaths. Also, CAD therapeutic strategy, patient based, may vary from basic useful with limited expenses to very complex non useful and very e...
Background Identifying patients with ischaemic left ventricular dysfunction that would benefit from revascularisation is challenging. The aim of this study was to investigate the role of cardiovascular magnetic resonance (CMR) imaging in the decision making process in patients being considered for revascularisation.
Methods All patients referred fo...
Background
Viability assessment prior to revascularisation at our institution is largely requested for patients with severely impaired left ventricles (LV). This study however aims to review the outcomes of those patients with preserved or mildly impaired LV function who underwent cardiac magnetic resonance imaging (CMR) for assessment of viability...
Acute kidney injury (AKI), defined as a rise in serum creatinine of >25% from baseline measured at 48 hours following renal insult, may follow iodinated contrast coronary angiography. Termed contrast-induced nephropathy (CIN), it can result in considerable morbidity and mortality. Measurement of serum creatinine as a functional biomarker of glomeru...
Background:
Individualised care at the end of life requires professional understanding of the patient's perception of implantable cardioverter defibrillator deactivation.
Aim:
The aim was to evaluate the evidence on patients' perception of implantable cardioverter defibrillator deactivation at end of life.
Design:
Systematic narrative review o...
Citations
... Subsequently, the problem of chronic cardiovascular disease is also highlighted in these survivors, who are more predisposed to developing cardiovascular disease (CVD) than those without a history of cancer (4,5). More importantly, developed CVD drastically reduces survival and primarily contributes to non-rectal deaths (6,7). It follows that uncovering the characteristics and mechanisms of CVD in patients with rectal cancer has become a current focus of research. ...
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... Evidence for NT-proBNP is therefore heterogeneous, with a moderate predictive ability in adult and childhood cancer survivors [24,25,29]. Furthermore, as natriuretic peptide levels may be affected by patients with metastatic disease, as well as in those with an elevated or low body mass index, imaging should fundamentally be a part of a surveillance programme [30]. Based on current evidence, the ESC recommended an annual assessment of natriuretic peptides alone for long-term posttreatment surveillance [4]. ...
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... These radioisotopes are used in a variety of applications, including radiopharmacy, nuclear medicine, and research. This is true in light of the findings, which indicate that the supply and availability of these radioisotopes have been reduced, postponed, or completely halted 25,[31][32][33][34][35] . ...
... In fact, about 30% of the cohort were taking monotherapy (TAC or EVR) and both regimens seemed to not influence the HR or the antibody titres. This data must be confirmed in a larger specific study on the minimisation or withdrawal of IS [2,[36][37][38]. Following the Italian Consensus Guidelines [12], in the present cohort, the choice of IS and their dose was made by clinicians based on the indication for LT and the specific disease aetiology or based on the expected IS side effects and patient comorbidities. ...
... Both the British Society of Echocardiography (BSE) and the British Society of Cardio-Oncology (BCOS) define cardiotoxicity as a decrease in LVEF by more than 10%, resulting in an LVEF value below 50% [14]. Additionally, the European Society of Medical Oncology (ESMO) interprets cardiotoxicity as a decline in LVEF exceeding 20% [15]. ...
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... In patients with acceptable image quality, current cardio-oncology guidelines and position papers recommend the use of echocardiography-measured 3D left ventricular (LV) volumes and LVEF measurements over 2D measurements [1,2,6,7]. These recommendations are supported by (i) data on the accuracy of 3D LVEF measurements in cancer [8] and non-cancer populations when compared to CMR LVEF [9] and (ii) the demonstration of superior reproducibility of 3D LVEF measurements compared to 2D LVEF in patients receiving cancer therapy [10,11]. ...
... intravascular imaging, increasing the stay duration and mortality. 5,19 Currently, there is a lack of specific clinical medications and interventions for CI-AKI occurrence. 20 The primary focus for addressing this condition remains on preventing its pathogenic mechanism and mitigating risk factors. ...
... During the last decades, the biomarkers, including NGAL, cystatin C, β2 microglobulin, α-1 microglobulin, and urinary insulin-like growth factor binding protein 7, have been proposed for the early detection of AKI. For instance, urinary NGAL is increased within 2 hours after CM administration and can predict the occurrence of CIN approximately 24 hours before SrCr increase (40). However, in the 6 Iran J Pharm Res. ...
... [81][82][83] In a USA study, Latinx patients and those described generically by the authors as 'Asians' were more likely to prefer family-centred decision-making than other racial or ethnic groups. 84 Self-reported race was found to be a significant predictor of ACP and treatment decisions even after controlling for socio-demographic factors. 85 However, for many patients, the lack of any opportunity to discuss ACP was most concerning and described as unsatisfactory and disempowering. ...
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