Mark A Moyad's research while affiliated with Concordia University–Ann Arbor and other places

Publications (167)

Article
Patients using nutraceuticals represent a diverse patient population with a keen potential interest and/or adherence to healthy lifestyle changes. BPH nutraceuticals, including saw palmetto were as safe, but not more effective than placebo in the STEP and CAMUS clinical trials, but another high-quality saw palmetto product could be tested in a phas...
Article
Full-text available
PurposeTo review the potential ancillary cardiovascular and other health impacts of compliance with general adult vaccination series in the prostate cancer active surveillance (AS) population. No previous review has been published in regard to this specific topic.Methods Literature review of PubMed data up to December 2020ResultsCompliance rates fo...
Article
Full-text available
Purpose of review: To discuss the overall and latest observations of the effect of diet, lifestyle, supplements, preventive vaccinations, and some prescription heart healthy medications for prostate cancer prevention within a 3-part series of publications. Recent findings: The concept of maximizing heart health to prevent aggressive prostate can...
Article
Full-text available
Purpose of review: To discuss the overall and latest observations of the effect of diet, lifestyle, supplements, and some prescription heart healthy medications for prostate cancer prevention. Recent findings: The concept of maximizing heart health to prevent aggressive prostate cancer continues to be solidified with the addition of more prospec...
Article
Full-text available
The article ‘‘Immunogenic Yeast-Based Fermentation Product Reduces Allergic Rhinitis-Induced Nasal Congestion: A Randomized, Double-Blind, Placebo-Controlled Trial’’, written by Mark A. Moyad, Larry E. Robinson, Julie M. Kittelsrud, Stuart G. Reeves, Susan E. Weaver, Aireen I. Guzman, Mark E. Bubak was originally published electronically on the pub...
Article
Full-text available
Purpose of Review To discuss the overall and latest observations of the effect of diet, lifestyle, supplements, and some prescription heart healthy medications for prostate cancer prevention. Recent Findings The concept of maximizing heart health to prevent aggressive prostate cancer continues to be solidified with the addition of more prospective...
Chapter
Cardiovascular disease (CVD) has been the number one cause of death in the United States for approximately 114 of the last 115 years. The majority of the research on specific lifestyle factors that could contribute to CVD also suggests similar lifestyle factors cause or encourage the progression of prostate cancer. And, lifestyle changes that reduc...
Article
Full-text available
Improved diagnosis and treatment regimens have resulted in greater longevity for men with prostate cancer. This has led to an increase in both androgen deprivation therapy (ADT) use and duration of exposure, and therefore to its associated adverse effects, such as sexual dysfunction, osteoporosis, reduced muscle mass, increased fat mass, and increa...
Chapter
“Vitamin E is dangerous!” “Herbal products have no evidence!” ______ does not treat or cure advanced cancer“? “Supplements don’t do anything, so don’t waste your money!” For almost 30 years I have watched not just patients, but especially some influential clinicians generalize, embellish, and misconstrue data on dietary supplements. This type of co...
Book
This book is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety ofdietary supplements and other complementary medicines that physicians are exposed to in their daily practice. The growing list of CAM products that could interfere with surger...
Chapter
The acronym S.A.M. (statins, aspirin, metformin) is a simplistic clinician and patient method of remembering the three most important off-label “natural” products that should be primarily discussed with individuals concerned about breast cancer. And simultaneously it sends a message to patients to always consider the largest source of morbidity and...
Chapter
The acronym S.A.M. (statins, aspirin, metformin) is a simplistic clinician and patient method of remembering the three most important off-label “natural” products that should be primarily discussed with individuals concerned about breast cancer. And simultaneously it sends a message to patients to always consider the largest source of morbidity and...
Chapter
It is critical to keep in mind, especially in this chapter that multiple lifestyle options exists that can improve or actually not improve and even exacerbate side effects from cancer treatments. And there are many integrative medicines, especially dietary supplements that can improve, have no impact or actually cause a side effect from cancer trea...
Chapter
The impact of a variety of integrative medicines on breast cancer prevention, ancillary treatment, and the treatment of side effects has arguably more research accumulated compared to any other cancer. The field moves quickly and the ability to learn about the latest options that work and are worthless need to be reviewed whether they impact the co...
Chapter
The acronym S.A.M. (statins, aspirin, metformin) is a simplistic clinician and patient method of remembering the three most important off-label “natural” products that should be primarily discussed with individuals concerned about breast cancer. And simultaneously it sends a message to patients to always consider the largest source of morbidity and...
Chapter
The primary cause of mortality in the USA and in most developed countries is cardiovascular disease (CVD), and it is the primary or secondary cause of death in the largest clinical trials ever conducted for preventing or treating breast cancer. The overall risk of mortality needs to be placed into perspective, and it does not serve to belittle the...
Article
Full-text available
Cardiovascular disease (CVD) has been the number one cause of death in the U.S. for 114 of the last 115 years. Lifestyle factors that promote CVD also appear to increase prostate cancer risk and those that reduce CVD risk also appear to reduce the risk of prostate cancer. The largest randomized trials utilizing dietary supplements or pharmacologic...
Chapter
Complementary & Alternative Medicine for Prostate and Urologic Health is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. This...
Chapter
Multiple lifestyle changes have the ability to prevent bladder cancer (smoking cessation, reduce arsenic concentrations in water, increase cruciferous vegetable intake, etc.), and some dietary supplements, such as Lactobacillus casei Shirota, have the ability to reduce recurrence rates after superficial bladder cancer treatment from three randomize...
Chapter
The primary cause of mortality in the USA and in most developed countries is cardiovascular disease (CVD), and it is the primary cause of death in the largest clinical trials ever conducted for preventing a variety of urologic health conditions. The overall risk of mortality needs to be placed into perspective. It does not serve to belittle the ser...
Chapter
It appears that reducing the risk of cardiovascular disease (CVD) may also be the ideal diet and lifestyle program to reduce the risk of kidney stones. Comprehensive lifestyle changes and healthy-heart parameters have synergistic impacts on reducing recurrent or incident nephrolithiasis as observed either in randomized trials from Parma, Italy, or...
Chapter
Oxidative stress is associated with up to 80 % of the male subfertility cases. A notable Cochrane Database of Systematic Reviews provided one of the most extensive analyses of 34 randomized trials of supplements for male subfertility during ART (assisted reproductive technologies). It found a highly statistically significant increased chance of pre...
Chapter
Aging, genetics, and a family history of BPH/LUTS can profoundly increase the risk of these conditions. Yet the observation that prescription alpha-blocker (originally designed to reduce blood pressure) medications could quickly reduce BPH severity for some men, along with decades of lifestyle research, now suggests that BPH prevention and perhaps...
Chapter
Pursuing high doses of antioxidants to prevent or assist in the treatment of prostate cancer may be simply providing impetus for more disease. It is important to ?first do no harm? and think of heart-healthy regimens or CAM products that could simultaneously prevent or reduce the progression of cardiovascular disease and prostate cancer. This metho...
Chapter
A plethora of complementary and alternative medicine (CAM) interventions, primarily dietary supplements, have been utilized in some preliminary clinical trials that have demonstrated an ability to reduce the symptoms of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). However, the one supplement that arguably had the most posit...
Article
Full-text available
Active surveillance (AS) is a widely recognized and utilized option by which prostate cancer patients with less aggressive tumors on diagnosis defer immediate traditional conventional therapy (surgery, radiation) and undergo close monitoring by a physician for any clinical or pathologic changes. The juxtaposition of low- to intermediate-risk elderl...
Chapter
“Heart health is tantamount to fertility and erectile health,” and “first do no harm” are the mantras of this chapter. Lifestyle changes to improve fertility and erectile function are no longer a theory, but sufficient clinical data exists to emphasize a variety of heart healthy behaviors to enhance overall male health, and specific urologic concer...
Chapter
State-of-the-art guidelines for sexual health or erectile dysfunction (ED) and female sexual dysfunction (FSD) provide extensive overviews of conventional prescription and other extrinsic treatment options. Yet, over the past 10–20 years, a plethora of international research has established that individual and comprehensive lifestyle changes can pr...
Chapter
Multiple lifestyle changes have the ability to prevent OAB and incontinence, including the ability to go beyond Kegel exercises for improvement utilizing more rigorous weight loss and core abdominal exercises. Even side effects of primary prostate cancer treatments appear to be greatly attenuated with these methods and with overall improvement in c...
Article
To the Editor Dr Bosland and colleagues1 found no effect of a soy protein isolate on biochemical recurrence of prostate cancer. I believe there were problems with the choice of both the intervention and placebo products.The soy isolate was not a true isolate because this would imply a concentrated protein source with minimal additive ingredients. H...
Article
Sexual health or erectile dysfunction (ED) state of the art guidelines provide a thorough overview of conventional prescription or other notable extrinsic treatment options. Yet, over the past 10-15 years, a plethora of international researchers have established that individual and comprehensive lifestyle changes can prevent and potentially improve...
Chapter
Almost all major and minor urologic conditions are impacted positively and negatively by certain lifestyle changes and dietary supplements. Some of these complementary interventions have potential positive impacts independently or in combination with conventional therapy, others have no activity, and some could negatively impact treatment and overa...
Article
The primary cause of mortality in most developed countries is cardiovascular disease, which is the primary cause of death in the largest clinical studies of male health conditions. There are simplistic correlations between heart health and male-specific diseases. Clinicians need to motivate and provide a simplistic and realistic set of lifestyle, d...
Article
The Selenium and Vitamin E Cancer Prevention Trial (SELECT) randomized over 35 000 men into four groups: high-dose vitamin E (400 IU day−1), high-dose selenium (200 mcg day−1), combination of vitamin E and selenium, or placebo.1 The brief time period to reach full recruitment was unprecedented; thus, it seemed that participants and health-care prof...
Article
Almost all aspects of urology are affected positively and negatively by certain lifestyle changes and dietary supplements. Some of these interventions have potential profound impacts independently or in combination with conventional therapy, others have no impact, and some could negatively impact treatment and overall health. The heart-healthiest r...
Article
The controversy over androgen deprivation therapy (ADT) for prostate cancer seems to have shifted over the past decade. The issue of adverse events or side effects now seems to dominate over that of clinical efficacy. However, this article provides evidence that questions the treatment of these side effects with numerous prescription medications th...
Article
Support for a prescription statin clinical trial for the prevention or treatment of prostate cancer has been lacking, although recent data have provoked interest in such a study. The authors have initiated a pilot trial of red yeast rice (RYR) extract and prostate cancer. RYR significantly reduces low-density lipoprotein and is an option for statin...
Article
Prostate and other cancers have a multitude of potential markers that can be used in laboratory and clinical studies of diet and dietary supplement interventions. More overt clinical markers include imaging tests, biopsy samples, prostate-specific antigen kinetics, and urinary testing. Many molecular markers are currently available, including antia...
Article
There are certain comments derived from ­observational clinical research and television commercials that are almost beginning to sound cliché in the urologic world and this is remarkable if one looks back just a few years on the ­educational progress that has occurred in the area of sexual health. For example, the relationship between erectile dysf...
Article
The use of statins, which are cholesterol-lowering drugs, has increased significantly during the last decade. In this study, we investigate the effect of statins on serum prostate-specific antigen (PSA) levels in men participating in a prostate cancer screening event. A cohort of 4903 men who participated in Prostate Cancer Awareness Week in the ye...
Article
Full-text available
The common cold has a profound impact on employee attendance and productivity. Seasonal influenza is responsible for approximately 200,000 hospitalizations and 36,000 deaths per year in the United States alone. Over-the-counter medication efficacy has been questioned, and seasonal vaccination compliance issues abound. Our previously reported random...
Article
Lifestyle changes It is imperative that clinicians never gloss over the importance of lifestyle changes for overall health and male fertility. It is interesting that most heart-unhealthy behaviors also negatively impact almost all other areas of male health [1], including fertility [2], and that improving heart health or encouraging heart-healthy c...
Article
Complementary and alternative medicine utilization continues to abound, as does the use of prescription medications. Thus, real and hypothetical concerns exist for potential drug-dietary supplement interactions. Several supplements, including kava and St. John's Wort, have the potential for adverse medication interactions, but there are also severa...
Article
H1N1, seasonal flu, and upper respiratory infection over-the-counter (OTC) prevention recommendations seem daunting, but in reality, only several diverse lifestyle changes, supplements, and prescriptions have adequate evidence that should be discussed with patients. In addition, numerous other recommendations contain little to no evidence. For exam...
Article
Full-text available
Allergic rhinitis (AR) impacts around 25% of the worldwide population. However, cost, safety, and a high dissatisfaction rate with numerous conventional medications continues to be an issue in the largest patient surveys, due primarily to a lack of efficacy on nasal congestion. Our previously published randomized trial demonstrated a significant re...
Article
A previously published randomized trial found a significant difference in the proportion of individuals experiencing oxalate reduction with a vitamin C with metabolites product compared with ascorbic acid (vitamin C). This represented a notable finding, which argued against the possibility of a chance finding due to the design and consistency of re...
Article
The incidence and prevalence of kidney stones are notable and are projected to increase over the next decade. Risk factors for kidney stones abound, but a prominent risk factor is hyperoxaluria, which has numerous etiologies, including vitamin C (ascorbic acid) dietary supplement intake. This randomized, double-blind, crossover study examined the e...
Article
Interest in all aspects of vitamin D seems to be surging due to perhaps the increased number of diverse positive studies suggesting it could prevent a variety of chronic diseases. However, before patients and health care professionals are educated on the preventive aspects of this vitamin that acts more like a hormone, a basic rapid review of vitam...
Article
The objective of this study was to test the effects of acute doses of vitamin C alone, calcium ascorbate with vitamin C metabolites, and placebo, on total plasma and leukocyte vitamin C concentrations over 24 hours. A double-blind, placebo-controlled, four-way crossover study was performed consisting of four separate phases lasting 24 hours each an...
Article
Bladder cancer results from complex and only partially understood host-environmental interactions. Tobacco smoking is the greatest risk factor for bladder cancer, but the actual risk to an individual reflects not only the amount of exposure to the carcinogens in tobacco smoke but also host susceptibility to these carcinogens and possibly other fact...
Article
Benign prostatic hyperplasia (BPH) and other prostatic diseases share many observational and mechanistic features with cardiovascular disease. Both BPH and cardiovascular disease increase significantly with age and affect a disproportionate number of men from racial/ethnic minority populations. Pharmacotherapy and surgical options are the treatment...
Article
Conventional and alternative medicine advice abounds in the area of seasonal allergies. The number and cost of choices can be daunting to any health care professional or patient. A quick overview is needed for consumers to review simplistic lifestyle changes and non-prescription options for this year's allergy season. For example, increasing laundr...
Article
To evaluate the primary causes of death in low-risk (low-risk), intermediate-risk (intermediate-risk), and high-risk (high-risk) patients undergoing permanent prostate brachytherapy with or without supplemental therapies. From April 1995 through November 2004, a total of 1,354 consecutive patients underwent prostate brachytherapy. All patients unde...
Article
Full-text available
The 2007-2008 cold and flu season had a feeble beginning but a dramatic end. Most states in the U.S. were reporting their highest number of flu cases well into February and March. It is concerning that not only the public but health care professionals have not embraced widespread vaccination because approximately 200,000 hospitalizations and 36,000...
Article
Yeast is the term generally applied to a unicellular fungus, and there are hundreds of species now identified. One of the most notable and well-known species of yeast in health and wellness is known as Saccharomyces cerevisiae, which is also known by its more common names, brewer's yeast or baker's yeast. Typically, brewer's yeast is used as a prot...
Article
Full-text available
A yeast-based product (EpiCor, a dried Saccharomyces cerevisiae fermentate) was compared to placebo to determine effects on the incidence and duration of cold and flu-like symptoms in healthy subjects recently vaccinated for seasonal influenza. In a 12-week, randomized, double-blind, placebo-controlled clinical trial, 116 participants received dail...
Article
Yeast is the term generally applied to a unicellular fungus, and there are hundreds of species now identified. One of the most notable and well-known species of yeast in health and wellness is known as Saccharomyces cerevisiae, which is also known by its more common names, brewer's yeast or baker's yeast. It is usually grown on hops or another subs...
Article
The life expectancy of African Americans and Caucasians has been increasing in the United States and in many other countries around the world since the late 1800s. However, as long as statistics have been accrued on race and ethnicity, the life expectancy of African Americans and Blacks in general has been significantly lower than that of Caucasian...
Article
Arguably, vitamin C has received more attention clinically and commercially compared with any other dietary supplement. First recognized as a way to eliminate scurvy and infections related to scurvy, recent studies utilizing this compound in a range of formulations and by itself show that it potentially may impact the risk of cancer, heart disease,...
Article
Arguably, vitamin C has received more attention clinically and commercially compared to any other dietary supplement. The strongest data for vitamin C appears to be as a nutrient that potentially enhances a combination product, and this has been observed in the areas of prenatal care, eye disease, general health maintenance, and immune enhancement....
Article
Men's health needs attention in terms of better awareness, improved lifestyle, and interventional options. An intense area of focus revolves around the potential to find a suitable agent for prostate cancer prevention. This intense area of interest or potential chemoprevention has witnessed improved funding for a variety of clinical trials. Some ha...
Article
Statins or cholesterol-lowering drugs seem to be the ideal next choice for a large chemoprevention or adjuvant trial in prostate cancer for numerous reasons, including 1) cardiovascular disease (CVD) has been the number one cause of death in men and women every year in the United States since 1900; 2) CVD has been the number one cause of death in t...
Article
The preliminary data appeared promising for men with hormone refractory prostate cancer (HRPC). The Food and Drug Administration advisory panel voted 13 to 4 to approve Provenge (sipuleucel-T) and the same panel voted 17 to 0 that it was safe. However, several weeks later the vaccine was not approved. Why did this happen? Why wasn't this novel ther...
Article
The number one cause of mortality in the United States and in most countries around the world is cardiovascular disease (CVD), and it is the number one or two cause of death in prostate cancer prevention trials and in prostate cancer patients. The overall risk of mortality needs to be placed into its proper perspective, and it does not serve to bel...
Article
This review integrates recent reports related to the dietary management of prostate cancer with the existing body of science in an effort to best inform practicing clinicians. Dietary factors are hypothesized to play a significant role in prostate cancer, and have proven to be important in managing prevalent comorbidities in this patient population...
Chapter
In general, overall sexual function tends to decline in healthy aging men (1). The latent time period between sexual stimulation and erection increases, erectile turgidity decreases, ejaculation is not as forceful, the volume of the ejaculate is reduced, and the interval between erections becomes longer. Testosterone levels and penile sensitivity t...
Article
Pfizer Inc. recently discontinued its billion-dollar investment and phase III clinical trial of their new high-density lipoprotein (HDL) or "good cholesterol" boosting drug torceptrapib because of unexpected life-threatening side effects. To provide an objective discussion with patients looking for the next miracle drug or even dietary supplement i...
Article
There are no national guidelines when comparing an aspirin daily to a statin drug in individuals with no history of a cardiovascular event (primary prevention). However, recent reviews of the medical clinical research on statins and aspirin for preventing a first coronary heart disease (CHD) event concluded that compared to no treatment, aspirin is...
Article
Vitamin E, once the highly espoused heart healthy paradigm of the dietary supplement world, has now been touted by many experts to be either heart unhealthy or simply ineffective based on the results of past and recent randomized trials in cardiovascular medicine. Natural and synthetic vitamin E supplements, especially in large dosages, have been t...
Article
This is the largest and longest clinical study to date to examine statin usage and overall patient survival following clinically localized prostate cancer. In a retrospective examination of 938 consecutive patients with early-stage prostate cancer treated with brachytherapy, 191 patients were documented to be taking statin medications. The patients...
Article
There are a variety of agents, dosages, and mechanisms involved in reducing cholesterol. Statins are the most well-known class and three of the six currently available agents have now lost patent protection. Thus, large reductions in price are expected in 2006-2007 across the entire class. The other classes of cholesterol-lowering agents include ta...
Article
Educating patients on the basic cardiovascular disease (CVD) risk markers such as cholesterol can be difficult in any medical setting, but especially in urology where patients are being evaluated for non-cardiovascular conditions. Primary reasons for discussing cholesterol or cardiac risk factors and assessment in urology include (a) the primary ca...
Article
Incorporating lifestyle changes to not only reduce the risk of prostate cancer but also more importantly to impact all-cause mortality is paramount to good health. In my experience, minimal time is needed to suggest these changes. These recommendations may seem simplistic, but past general studies of men have demonstrated that few (less than 5%) ha...
Article
This article has covered five simplistic steps for clinicians to emphasize to men to improve urologic and overall health. The next article covers other important steps to further enhance the ability of patients to exert some control over their health. Again, keeping the simple recommendation in mind that what is heart-healthy is tantamount to urolo...
Article
To conduct a preliminary investigation on statin use and its impact on clinical presentation and biochemical progression-free survival after brachytherapy. A total of 512 consecutive patients were treated with permanent brachytherapy for clinical Stage T1c-T3aNxM0 prostate cancer at least 3 years before analysis. Biochemical progression-free surviv...
Article
Understanding the meaning of glycemic index (GI) and glycemic load (GL) and learning these values from beverages and foods are a critical first step in understanding most of the low-carbohydrate diets. The GI is an approximation of the blood glucose changes that occur after an individual ingests 50 g of available carbohydrate from an individual bev...
Article
It is obvious that herbal dietary supplements have enjoyed a great deal of popularity and sales throughout the past decade and, in the area of prostate cancer prevention, this is especially the case. However, the lack of currently available evidence to indicate their effectiveness truly is a potential problem. In addition, the quality control, safe...
Article
The time is ripe to abandon free PSA screenings and replace them with free comprehensive health screenings. For example, cardiovascular disease (CVD) risk screening (cholesterol, blood pressure) that could also include PSA, weight measurement, and a variety of other tests and educational assessments just make more sense in terms of the larger pictu...
Article
The first three parts of this series of articles covered the basics of some of the more popular low-carbohydrate diets, and the theories behind them. In the fourth and final part of this series, some of the more popular low-fat and low-calorie diets, such as the Ornish diet and Weight Watchers, are covered briefly. Recently, several clinical trials...
Article
The correction of a subtle nutritional deficiency that may reduce the risk of a future chronic disease is indeed a challenge. However, some specific examples in the past, such as the addition of folic acid to prevent neural tube defects and calcium and vitamin D to prevent osteoporosis, should provide some encouragement that some conditions can be...
Article
Androgen deprivation for prostate cancer use to be applied only in the latter stage of the disease process, thus, the issue of promoting general health during this time was not a concern because the subject of life and death was more paramount. However, thanks to earlier detection of prostate cancer, there has been a general stage migration in this...
Article
The correction of a subtle nutritional deficiency that may reduce the risk of a future chronic disease is indeed a challenge. However, some specific examples in the past, such as the addition of folic acid to prevent neural tube defects and calcium and vitamin D to prevent osteoporosis, should provide some encouragement that some conditions can be...
Article
The pleiotropic effects of statins continue to garner attention. One area of interest that requires more attention is their potential, or that of another heart healthy agent, to impact favorably or inhibit the progression of numerous cancers, especially prostate cancer. Statins have accumulated a plethora of data in the area of general cancer cell...
Article
Several important observations should be kept in mind by cancer researchers: cardiovascular disease (CVD) is the number one cause of death; CVD is the number one cause of death in the largest cancer chemoprevention trials; CVD is the number one or two cause of death in prostate cancer patients; and some of the mechanisms that increase the risk of C...

Citations

... Vaccination has both overt benefits and less well known potential ancillary advantages for AS patients. Healthy lifestyle changes have positive benefits on general health outcomes [4,5]. Lifestyle changes, including diet and exercise and other interventions, are synergistic with vaccine compliance and efficacy. ...
... These compounds are chemically and metabolically stable, and this increased the concern in the rational design of novel organoselenium agents [21,22]. The latter was confirmed by animal model and intervention studies and pre-clinical trials (e.g., NPC, SELEBLAT, and SELECT) [23]. Subsequently, this fact served as an impetus for the rational design of organic selenide-based chemoprotective and antioxidant agents [24,25]. ...
... Therefore, the need for well-designed trials to expand the existing knowledge, replicate the findings, and aggregate the results is necessitated [231]. Moreover, the efficacy of supplements and, in particular, antioxidants, in tampering down PSA concentrations is questionable and a "first do not harm" concept must prevail before the formulation of any recommendations [232]. Given that the majority of evidence outlined in the present review revealed little or no effect, it can be assumed that nutrition-wise, PSA is not as sensitive as we might think, whereas the role of nutrition in down-regulating PSA concentrations appears to be minimal. ...
... Furthermore, increasing age, time since diagnosis and comorbidities amplify physical morbidity, poor symptom control, high perceived fatigue and in general a poor health-related quality of life (QoL), as well as psychosocial concerns (e.g., mood changes, distress) [8,9]. Nutritional status is pivotal to manage not only fatigue and quality of life (QoL) [10,11], but also to reduce PCa-specific mortality [12,13]. ...
... Surgery, radiation and systemic therapies (chemotherapy, hormonal and target) are some of the current breast cancer treatment modalities available, depending on the extent and type of cancer [3]. Some of these treatments may present some limitations since, besides affecting the tumor, they also affect the surrounding healthy environment, and may present some side effects [3,4]. For these reasons, the use of natural substances is an interesting alternative due to their low toxicity and biological and chemical similarities to native tissue compositions. ...
... Many people with CP/CPPS, BPH and kidney stone disease are not satisfied with conventional treatment options and they try alternative therapies: diet and lifestyle modifications, phytotherapy, acupuncture, myofascial physical therapy, and psychosocial factors (15)(16)(17). The symptoms CP/CPPS can worsen from spicy food, coffee, alcoholic beverages, while other nutrients, such as psyllium, water, herbal teas, and polycarbophil, can improve condition of patients with this disorder (18). ...
... It is biosynthesized by almost all organisms except humans. It is widely known as the vitamin whose deficiency causes scurvy in humans (Li, Byers, and Walvekan 2008; Velandia et al. 2008; Moyad and Combs 2007). Biotin, also known as vitamin H or B 7 (coenzyme R, Biopeiderm;Fig. ...
... 20 Caloric reduction in overweight and obese patients with or without hypertension may also provide similar benefits. 1,21 MULTIVITAMINS/DIETARY SUPPLEMENTS Some of the largest past prospective epidemiologic studies are suggesting a greater rate of aggressive and fatal prostate cancer when consuming more than 1 multivitamin a day, and a potential further increasing risk when other high-dose individual supplements are also utilized (selenium, Vitamin E and zinc). 22 Men with a family history of prostate cancer appeared to experience the largest and most significant elevated risks of this condition. ...
... In the 2-week, 3-month, or 2-year gavage studies, no significant safety issues were reported. Therefore, researchers concluded that even when ginseng was administered at a dose of 5000 mg/kg, it was neither tumorigenic nor toxic [69]. No safety issues of concern have been noted in the past laboratory studies exploring the effect of Panax ginseng on sexual function. ...
... The insistence that lifestyle can improve health and be helpful to treat diseases has been posited by many authors [30][31][32][33][34]. Some articles targeted specific groups on the basis of age [35,36]. ...