Marina Merkel's research while affiliated with Charité Universitätsmedizin Berlin and other places

Publications (3)

Article
Background Few studies have thoroughly investigated the causes of kidney graft loss (GL), despite its importance. Methods A novel approach assigns each persistent and relevant decline in renal function over the lifetime of a renal allograft to a standardized category, hypothesizing that singular or multiple events finally lead to GL. An adjudicati...
Article
Full-text available
Background: The number of patients returning to dialysis after graft failure increases. Surprisingly, little is known about the clinical and immunological outcomes of this cohort. Methods: We retrospectively analyzed 254 patients after kidney allograft loss between 1997-2017 and report clinical outcomes such as mortality, relisting, retransplant...

Citations

... Table 1. Traditional immunologic and non-immunologic risk factors for allograft loss (Adapted from ref. [8,9]). Recent efforts have focused on better characterization of allograft loss and described a more complex picture of the multifactorial pathogenic processes. ...
... The Spanish health system guarantees to chronic kidney disease population universal evaluation for KT feasibility as demonstrated by the fact that almost 60% of patients are relisted for second transplantation in our cohort. Similar [13] or lower [14] overall relisting in patients with allograft failure are depicted in other studies. Despite this fact, after the first kidney graft failure, we observed that the probability to receive a second KT is similar to dying. ...
... Among European and US patients who experienced death-censored graft failure, 48% were waitlisted (median time 7.7 months) and 61% had HLA antibodies; most of the sensitized patients were not relisted for transplantation and remained on dialysis until death (20). A publication from Charité Hospital in Berlin found that between 1997 and 2017, 267 graft losses occurred in 254 patients, resulting in 117 (43.8%) relistings (21), of whom only 42 (35.9%) patients received a second transplant. ...