Mariette Barbier's research while affiliated with West Virginia University and other places

Publications (3)

Article
Full-text available
Background Lung airway epithelial cells are part of innate immunity and the frontline of defense against bacterial infections. During infection, airway epithelial cells secrete proinflammatory mediators that participate in the recruitment of immune cells. Virulence factors expressed by bacterial pathogens can alter epithelial cell gene expression a...
Article
Full-text available
Despite high vaccine coverage in many parts of the world, pertussis is resurging in a number of areas in which acellular vaccines are the primary vaccine administered to infants and young children. This is attributed in part to the suboptimal and short-lived immunity elicited by acellular pertussis vaccines and to their inability to prevent nasal c...
Article
Full-text available
Well-adapted pathogens must evade clearance by the host immune system and the study of how they do this has revealed myriad complex strategies and mechanisms. Classical bordetellae are very closely related subspecies that are known to modulate adaptive immunity in a variety of ways, permitting them to either persist for life or repeatedly infect th...

Citations

... As a result, there has been an increased effort to develop next generation vaccines that can provide a longer duration of protection. In the past decade, the field has accumulated a large amount of evidence which demonstrates that aP vaccines (DTaP and Tdap) are effective at preventing death in infants but that the immunity they provide is short-lived and does not prevent transmission [5][6][7][8]. ...
... are respiratory pathogens that can cause disease in humans (Bordetella pertussis, B. parapertussis) or a broad variety of mammals, including humans (B. bronchiseptica) (1)(2)(3). They are the causative agents of whooping cough or whooping cough-like disease, and, despite the international vaccination efforts to eradicate this disease, incidence has increased since the move to acellular vaccines (4)(5)(6). ...