Maria Iacovidou's research while affiliated with City University of New York - Hunter College and other places

Publications (4)

Article
Juzen-taiho-to (JTT) is an immune-boosting formulation of ten medicinal herbs. It is used clinically in East Asia to boost the human immune functions. The active factors in JTT have not been clarified. But, existing evidence suggests that lipopolysaccharide (LPS)-like factors contribute to the activity. To examine this possibility, JTT was subjecte...
Article
Juzen-taiho-to is an immunostimulatory herbal formulation that is clinically used in East Asia for cancer patients undergoing chemotherapy and radiation. The formulation stimulates various leukocytes, including T, B, and NK cells and macrophages. Although Juzen-taiho-to is known to contain numerous compounds with various pharmacological activities,...
Article
A new diterpene with a fused 5-8-5 ring system was isolated from the fermentation broth of a soil actinomycete. The stereochemistry at C-15 was determined in an unusual manner using a decomposition product.
Article
From Toki-shakuyaku-san, an herbal formulation for 'cleansing stagnated blood,' a key gene regulatory compound was purified and identified through a screening based on DNA microarray and real-time PCR.

Citations

... However, while vegetable leaves are well populated with bacteria including potential probiotic acting Lactobacillus strains [34][35][36][37], so far, plant-derived produce has only been considered as vehicles of probiotic cultures [38,39]. A detailed understanding of how probiotic bacteria colonize leafy vegetables or herbs would enable future approaches to enrich these tissues with the respective bacterial strains to elevate vegetable leaves beyond their basic nutritional values. ...
... Liu et al. reported that JTT promoted the differentiation of transplanted bone marrow cells into microglia in the injured mouse brain [9]. Takaoka et al. reported that glycolipids of JTT stimulated macrophages [27]. Furthermore, Onishi et al. reported that JTT activated macrophages and T cells and prevented the metastasis of colon cancer cells to the liver in mice [13]. ...
... They were first isolated as glycosides from the phytopathogenic fungus Fusicoccum amygdali, in 1964 [81]. Substances exhibiting this structural motif have been isolated from a variety of sources including fungi such as Talaromyces purpureogenus, Alternaria brassicicola XXC, and Trichoderma citrinoviride cf-27 ( Figure 3), and rarely from liverworts, algae, ferns, streptomycetes, and higher plants, some of which showed remarkable biological effects relevant for drug discovery, such as antibacterial, antitumor, anti-inflammatory, and antifungal activities [82][83][84][85][86][87][88][89]. A new diterpenoid roussoellol C 26 that exhibited moderate antiproliferative activities against human breast adenocarcinoma (MCF-7) cell line with an IC50 value of 6.5 μM has been isolated from an extract of laboratory cultures of the marine-derived fungus Talaromyces purpurogenus [90]. ...
... Previous studies have indicated that TSS improves iron deficiency anemia [6][7][8] and leukorrhagia [9]. Moreover, it had been reported that TSS may increase cerebral blood flow [10,11], reduce oxidative stress in the central nervous system [12], inhibit platelet aggregation [13], regulate thrombosis in endothelial cells [14], and relax vascular smooth muscle [15]. Table 1 shows the comparative clinical symptoms and signs between Flammer syndrome and the indications for use of TSS. ...