Maria E Bleil's research while affiliated with University of Washington Seattle and other places

Publications (53)

Article
Objective: This study examined predictors of physical performance, a key aspect of quality of life, in children with excess weight. Methods: Participants were 269 children aged 6-12 years with a body mass index above the 85th percentile. Children completed a standardized physical performance task capturing lower extremity strength, balance, and...
Article
Full-text available
Objective: Although exposure to abuse in early life predicts earlier pubertal timing, especially for girls, it is unclear if this association generalizes to non-abuse stressors. Additionally, the impact of race on the stress-maturation association remains unknown. To address these issues, we examined whether race moderates the effects of early adv...
Article
Impacts of the COVID‐19 pandemic in the United States have been exacerbated by pre‐existing inequities in resources and opportunities, leaving the most vulnerable to face a multitude of hardships. The goal of the current study was to characterise COVID‐19–related stressful life events in specific life domains and to identify the sociodemographic ch...
Article
Context: Prepubertal obesity is a well-established predictor of earlier pubertal onset, which is itself a risk factor for poor health and well-being. Identifying specific patterns of weight gain in early life may help explain differential risk for earlier pubertal onset. Objective: The objective of the study was to examine patterns of weight gai...
Article
The effectiveness of Promoting First Relationships (PFR), a 10-week home visiting program with video feedback, was tested in a randomized controlled trial involving 252 mothers and their 8- to 12-week-old infants. Mothers were eligible if they initiated treatment after mental health screening (depression, anxiety, posttraumatic stress disorder [PTS...
Article
Early life adversities (ELA), include experiences such as child maltreatment, household dysfunction, bullying, exposure to crime, discrimination, bias, and victimization, and are recognized as social determinants of cardiovascular disease (CVD). Strong evidence shows exposure to ELA directly impacts cardiometabolic risk in adulthood and emerging ev...
Article
Full-text available
Mounting evidence that early life adversity (ELA) exposures confer risk for cardiometabolic disease over the lifespan motivated this narrative review to examine parenting quality as a potential intervention target to reduce ELA exposures or mitigate their impact as a way of reducing or preventing cardiometabolic disease. We describe findings from t...
Article
Full-text available
Background The COVID-19 pandemic is a crisis unprecedented in its size and scope. Yet studies of resilience suggest most individuals will successfully negotiate this challenge and some may even experience growth and positive change. Some evidence suggests that the capacity to enact positive change in the face of adversity may be shaped by early lif...
Article
Background: Executive functions (EF) support engagement in goal-directed behaviors, including several health behaviors. Stressful and cognitively demanding events can disrupt EFs and interfere with health behavior, possibly to a greater extent in those with preexisting EF deficits. This study examined the association between preexisting EF deficit...
Article
Objective: To identify early life adversity (ELA) risk factors for earlier pubertal timing, itself a risk factor for poor cardiometabolic health, and to determine whether such ELA-related risk may be mediated by pre-pubertal body mass index (BMI). Methods: Subjects included 426 female participants in a prospective birth cohort study, the NICHD S...
Preprint
Full-text available
Increasingly, attachment representations are being assessed via secure base script knowledge - the degree to which individuals show awareness of the temporal-causal schema that summarizes the basic features of seeking and receiving effective support from caregivers during times of need. Limited research has assessed the links between secure base sc...
Preprint
Full-text available
Increasingly, attachment representations are being assessed via secure base script knowledge—the degree to which individuals show awareness of the temporal-causal schema that summarizes the basic features of seeking and receiving effective support from caregivers during times of need. Limited research has assessed the links between secure base scri...
Article
NHLBI convened an interdisciplinary panel of experts in childhood adversity, social determinants of health, and cardiovascular disease (CVD) for a collaborative workshop, entitled “Social Determinants of Health: Early Life Adversity as a Contributor to Disparities in Cardiovascular Diseases.” This manuscript reports workshop proceedings addressing...
Article
Full-text available
Background: Because the ovarian follicle pool is established in utero, adverse exposures during this period may be especially impactful on the size and health of the initial follicle endowment, potentially shaping trajectories of ovarian follicle loss and the eventual onset of menopause. Building on a robust literature linking socioeconomic status...
Article
Full-text available
Compared to white girls, sexual maturation is accelerated in African American girls as measured by indicators of pubertal development, including age at first menses. Increasing epidemiological evidence suggests that the timing of pubertal development may have strong implications for cardio-metabolic health in adolescence and adulthood. In fact, you...
Article
The purpose of this study was to characterize reproductive concerns among female cancer survivors, and determine the role of targeted counseling in improving overall reproductive quality of life (QOL). A survey was administered to women from the California Cancer Registry, ages 18-40, with non-gynecologic cancers diagnosed from 1993-2007 who receiv...
Article
Objective: To determine the extent to which fertility patients and partners received mental health services (MHS) and were provided with information about MHS by their fertility clinics, and whether the use of MHS, or the provision of information about MHS by fertility clinics, was targeted to the most distressed individuals. Design: Prospective...
Article
Introduction: Major depressive disorder (MDD) is often precipitated by life stress and growing evidence suggests that stress-induced alterations in reward processing may contribute to such risk. However, no human imaging studies have examined how recent life stress exposure modulates the neural systems that underlie reward processing in depressed...
Article
Socioeconomic adversity in early life is related to cardiovascular risk in adulthood; however, no studies have examined whether such adversity may be related to endogenous sex hormones, which are themselves associated with cardiovascular outcomes, or whether the timing of adversity exposures (childhood vs. puberty) matters. The goal of the current...
Article
To examine the prevalence and predictors of major depressive disorder (MDD) for women and their partners during the course of fertility treatment. Prospective cohort study during an 18-month period. Participants completed interviews and questionnaires at baseline and at 4, 10, and 18 months of follow-up. Five community and academic fertility practi...
Article
To determine whether reproductive age, as indexed by a validated marker of ovarian reserve (antimüllerian hormone [AMH]), varies among women of different race/ethnic backgrounds. Cross-sectional study. Community-based sample. Multiethnic sample of 947 (277 white, 237 African American, 220 Latina, and 213 Chinese) healthy and regularly cycling preme...
Article
Caloric beverages may promote obesity by yielding energy without producing satiety, but prior laboratory and intervention studies are inconclusive. This study examined whether the diets of free-living overweight and obese women show evidence that calories from beverages are offset by reductions in solid food within individual eating occasions and a...
Article
Objective: The aim of this study was to evaluate the extent to which mild disruptions in ovarian function, indexed by changes in menstrual cycle length, may relate to cardiometabolic and psychological health in premenopausal women. Methods: Among 804 healthy, regularly cycling women (aged 25-45 y; mean [SD] age, 35.5 [5.5] y), patterns of any ch...
Article
Objective: The menopausal transition is associated with an increase in risk for cardiovascular disease; however, whether variability in reproductive aging relates to cardiovascular risk factors in the premenopausal period has not been studied. Methods: In a multiethnic sample of 951 healthy, regularly cycling women aged 25 to 45 years (mean [SD]...
Article
Objective: To determine whether greater childhood adversity relates to younger menarcheal age; whether younger menarcheal age relates to increased CVD risk; and whether greater childhood adversity relates to increased CVD risk, directly or indirectly (mediated by menarcheal age). Methods: Among 650 pre-menopausal women (ages 25-45; M=34.9[5.6]),...
Article
Context: Individuals with metabolically healthy or benign obesity vs. unhealthy or at risk obesity have been distinguished; however, the predisposing factors for developing these phenotypes are poorly understood. Objective: Our objective was to examine pubertal timing marked by menarcheal age in relation to at-risk obese, benign obese, and healthy...
Article
Full-text available
BACKGROUND Life history models suggest that biological preparation for current versus longer term reproduction is favored in environments of adversity. In this context, we present a model of reproductive aging in which environmental adversity is proposed to increase the number of growing follicles at the cost of hastening the depletion of the ovari...
Article
Objective: The aim of this study was to examine psychological factors in relation to antral follicle count (AFC), a marker of ovarian reserve, in a multiethnic sample of 683 premenopausal women in the Ovarian Aging (OVA) Study. Methods: In cross-sectional analyses, linear regression was performed to determine whether AFC decline across women var...
Article
To examine whether psychological distress predicts IVF treatment outcome as well as whether IVF treatment outcome predicts subsequent psychological distress. Prospective cohort study over an 18-month period. Five community and academic fertility practices. Two hundred two women who initiated their first IVF cycle. Women completed interviews and que...
Article
To evaluate the prospective relation between dispositional traits of optimism and pessimism and in vitro fertilization (IVF) treatment failure among women seeking medical intervention for infertility. Among 198 women (aged 24-45 years, mean [standard deviation] = 35.1 [4.1] years; white, 77%), the outcome of each participant's first IVF treatment c...
Article
The objective of the study was to characterize the backgrounds of women who have repeat abortions. In a cross-sectional study of 259 women (mean age, 35.2 ± 5.6 years), the relation between adverse experiences in childhood and risk of having 2 or more abortions vs 0 or 1 abortion was examined. Self-reported adverse events occurring between the ages...
Article
This study documents psychological problems in obese adolescents seeking bariatric surgery with laparoscopic adjustable gastric band. Depression, self-harm, suicidal ideation, anxiety, and bullying were reported frequently. Professionals will need to carefully assess adolescents for high-risk behaviors and provide appropriate follow-up care if thes...
Article
To assess depression, anxiety, and anger as well as the variance that these emotions share (conceptualized as negative affect) in relationship to high-frequency heart rate variability (HF-HRV), a specific indicator of parasympathetic cardiac autonomic function related to premature cardiovascular morbidity and mortality. Although individual trait ne...
Article
Individuals of low socioeconomic status (SES) are at increased risk for cardiovascular disease relative to persons of more advantaged social position. Recent evidence suggests that community SES (variation in the material and social resources of communities) also predicts incident cardiovascular disease, and may do so independently of individual le...
Article
The apolipoprotein E (apoE) polymorphism was evaluated alone, and in interaction with smoking status, in predicting carotid intima-medial thickness and plaque among 182 untreated, hypertensive, white men (mean age 56+/-8.9 years). After covariate adjustment (age, education, smoking, body mass index, systolic and diastolic blood pressure, glucose, t...
Article
We reported previously that the socio-economic status (SES) of individuals predicts variation in brain serotonergic responsivity, as assessed by neuropharmacological challenge in an adult community sample, and that this association is qualified by allelic variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR). Here we exam...
Article
To determine whether anger-related personality traits are associated with carotid artery atherosclerosis in untreated hypertensive patients. Study participants were 237 men with elevated blood pressure (systolic 140-180 mm Hg and/or diastolic 90-110 mm Hg) but untreated for hypertension. Average age was 56 years; 80% of subjects were white. Eighty-...
Article
To examine the effect of length variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) on individual differences in cardiovascular response to psychological challenge. Heart rate (HR) and systolic and diastolic blood pressure (SBP, DBP) responses to computerized versions of two psychological challenges, the Stroop Color-Wo...
Article
Exaggerated cardiovascular reactivity to behavioral challenges among otherwise healthy individuals has been associated with carotid atherosclerosis. We evaluated whether a similar relationship exists among hypertensives, who are at a heightened atherosclerotic risk. Untreated, hypertensive men (n=251; age range, 40 to 70 years; 197 white, 54 black)...

Citations

... The EPII, because it was developed to specifically assess the effects of COVID-19, has also not yet been fully validated. It has been used, however, in a number of recent publications to assess the toll that the pandemic has had on healthcare workers [29,30]. This study will add to the body of literature in this regard. ...
... Cardiovascular disease (CVD), including ischemic heart disease (IHD) and stroke, is the leading cause of mortality, accounting for about 27% of global deaths. 1 Emerging evidence has consistently recognized early life traumas (e.g., physical abuse and emotional neglect) as potent contributors to CVD, [2][3][4][5] with limited emphasis given to life course (both childhood and adulthood) traumatic experiences. 6 A life course approach addresses how life course exposures affect health inequalities using critical periods, 7 accumulative risk, 7 and chains of risk models. ...
... Although Varagiannis and collaborators recently proposed the "4 your family" program targeting 8-12-year-old children with overweight or obesity, families in their "home-based" intervention arm only followed an online program at home [13]. In 2016, Appelhans and colleagues also conducted a meta-analysis based on 15 interventions qualified as "home-based" family programs targeting pediatric obesity [14]. However, according to their analysis, only some clinical evaluations were performed at home, and the main intervention mainly consisted of phone calls with a maximum of one physical visit at the families' accommodation. ...
... Another developmental period of interest is puberty during which time the occurrence of ELA exposures may also confer excess cardiovascular risk (Bleil et al., 2015). Furthermore, the pathway of pubertal development itself is of interest as ELA exposures appear to accelerate the onset of puberty (Belsky et al., 1991;Moffitt et al., 1992;Ellis, 2004;Bleil et al., 2013Bleil et al., , 2021 and earlier pubertal timing, in turn, predicts post-pubertal weight gain, worsening CVD risk factor profiles, and incident cardiometabolic disease, and early mortality (Cooper et al., 1999;Frontini et al., 2003;Feng et al., 2008;Jacobsen et al., 2009;Lakshman et al., 2009). ...
... Over the life course, SES and CAs have been shown to be interrelated, yet few studies have attempted to disentangle the relation between child SES, CA and adult SES. Clarifying the relation between SES and CA could have implications for how we intervene to prevent CA and its associated negative health outcomes (Shaefer et al., 2018;Suglia et al., 2020). First, childhood SES is associated with CA exposure. ...
... This implies that at adolescence there is variability of body composition, confirming the influence of puberty on the linear growth pattern. Moreover, epidemiological reports have suggested that the timing of pubertal onset may be a key determinant of cardio-metabolic health in adolescence and adulthood, and there may exist racial and ethnic disparities of puberty onset timing [49]. Considering that puberty onset commences at adolescence, the disparity of pBMI cut-off obtained in this study to that of CDC cut-off may be accounted for by puberty, genetic and ethnic differences. ...
... 22 However, if survivors received in-depth reproductive counseling prior to treatment, they had lower levels of reproductive concerns. 23 In addition, reproductive concerns fully mediated the relationship between the importance of parenting and quality of life, and was reported to have association with depression. 24,25,30,39 ...
... A substantial body of research demonstrates that infertility is associated with psychological distress, with much of the extant literature finding that, within couples with infertility, women experience even greater distress than men. For example, Pasch et al. (2016) recruited 352 women and 274 men with infertility to examine the extent to which they experienced clinical levels of anxiety and depression. Findings demonstrated that 56.5% of women and 32.1% of men endorsed symptoms in the clinical range for depression, and 75.9% of women and 60.6% of men endorsed symptoms in the clinical range for anxiety. ...
... Heart rate variability (HRV) is a physiological phenomenon that describes the variation of the distance (time) between consecutive R waves (R-R Interval) in an ECG signal and reflects the balance between the sympathetic and parasympathetic systems (Malliani et al., 1991). HRV reduction has been associated with various disorders (Agelink et al., 2002; Bleil et al., 2008; Lavoie et al., 2004; Malpas and Maling, 1990; Martens et al., 2008). Several studies have been performed in MSA patients to investigate cardiac autonomic dysfunction describing HRV as a potential biomarker for distinguishing MSA from PD, progressive autonomic failure (PAF) and sporadic adult onset ataxias (SAOAs) (Abele et al., 2004; Diedrich et al., 2002; Furushima et al., 2012; Kitae et al., 2001; Kiyono et al., 2012; Toshihide et al., 2006 ). ...
... Among healthy participants, Treadway et al. (2013) found that greater perceived stress within the past month was associated with lower mPFC activation to reward outcome but not reward anticipation. In a sample of patients with major depression and control participants, Kumar et al. (2015) reported that participants with greater perceived life stress exhibited higher mPFC activation to reward outcome during an acute lab stress condition (negative performance feedback) than a nostress condition, and this effect was primarily attributable to the depressed participants. ...