Maria Buthut's research while affiliated with Charité Universitätsmedizin Berlin and other places

Publications (9)

Article
Background Radiotherapy in patients with primary brain tumors may affect hippocampal structure and cause dyscognitive side-effects. Patients and Methods Using structural MRI and comprehensive neurocognitive evaluation, we investigated associations between hippocampal structure and memory deficits in 15 patients with WHO grade 3 and grade 4 gliomas...
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Background Hallucinogen persisting perception disorder (HPPD) is characterized by spontaneous recurrence of visual hallucinations or disturbances after previous consumption of hallucinogens, such as lysergic acid diethylamide (LSD). The underlying physiological mechanisms are unknown and there is no standardized treatment strategy available.Case Pr...
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Objective Investigating retinal thickness may complement existing biological markers for dementia and other neurodegenerative diseases. Although retinal thinning is predictive for cognitive decline, it remains to be investigated if and how this feature aligns with neurodegeneration elsewhere in the brain, specifically in early disease stages. Meth...
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Background : Hippocampal thinning and carrying the ε4 allele of the apolipoprotein E (APOE) are associated with reduced cognitive performance in older people. Although cognitive impairment is also frequent during and after depressive episodes, it may occur irrespective of age, which makes it difficult to determine, whether this symptom indicates a...
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Background: Cognitive deficits are common in patients with a depressive episode although the predictors for their development and severity remain elusive. We investigated whether subjective and objective cognitive impairment in young depressed adults would be associated with cortical thinning in medial temporal subregions. Methods: High-resoluti...
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People with a first-degree family history of Alzheimer’s disease are at an increased risk of developing dementia. Subjective memory impairment among individuals with no measurable cognitive deficits may also indicate elevated dementia risk. It remains unclear whether nondemented people with a positive family history of Alzheimer’s disease are more...
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Diagnostic assessments for dementia include the evaluation of subjective memory impairment, dementia worries, or depressive symptoms. Data on the predictive value of these factors remain unclear, and varying help-seeking behavior may contribute to this finding. We investigate whether differentiating help-seeking motivation from other psychological...
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Die Bestrahlung des Gehirns ist ein wichtiges Verfahren in der Behandlung maligner und benigner Erkrankungen mit zerebraler Beteiligung. Der mögliche akute oder chronische Einfluss auf kognitive Leistungen ist für die Alltagskompetenz und Lebensqualität der Patienten wichtig und muss gemeinsam mit einer primären Kontrolle der Erkrankungsprogression...
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Buy Article Permissions and Reprints Abstract Driving ability in the elderly and cognitively impaired is of growing demographic relevance. Driving represents a complex task for which multiple central resources are needed. In mild cognitive impairment and dementia, we need to closely monitor driving ability, as it gets irrecoverably lost in the cou...

Citations

... A small number of studies have found associations between structural measurements of the brain with retinal measurements, although these studies, with the exception of the UK Biobank (Chua et al., 2021), have tended to involve older participants (≥ 65 years) or patients with diagnosed AD (Casaletto et al., 2017;den Haan et al., 2019;Donix et al., 2021;Jorge et al., 2020;Mejia-Vergara et al., 2021;Méndez-Gómez et al., 2018;Ong et al., 2015;Shi et al., 2019;Uchida et al., 2020;Ueda et al., 2022). The maximum clinical utility of retinal imaging in AD, however, is in the pre-diagnosis stages, before symptoms progress to the level where daily living is affected and irreversible neurological damage has occurred. ...
... Järnum et al. evaluated the morphological and functional brain abnormalities in limbic-cortical regions at baseline and after the 6-month follow-up in 23 patients who had had a major depressive episode and 26 healthy controls and found a significantly thinner posterior cingulate cortex in nonremitters than in remitters and a significant decrease in perfusion in the frontal lobe and anterior cingulate cortex in nonremitters compared with healthy controls at baseline (Jarnum et al., 2011). In addition, previous studies revealed that cortical thinning in parahippocampal and fusiform cortices were associated with subjective memory impairment measured by Fragebogens zur subjektiven Einschätzung der geistigen Leistungsfähigkeit (Questionnaire for Complaints of Cognitive Disturbances) among young patients with major depressive disorder (Donix et al., 2018). Saleh et al. reported a significant relationship between reduced cortical thickness in the bilateral insula and frontal cortex and cognitive deficits in working memory and processing speed (Saleh et al., 2017). ...
... The results of Wolfsgruber et al. (2022) are consistent with ours, which found that the first-degree family history of AD revealed higher SCD-plus scores than healthy controls. Another prospective cohort study has found that greater subjective memory impairment is associated with a first-degree family history of AD in healthy older adults (Haussmann et al., 2018). As we all know, the uncontrollable and common risk factors of dementia include aging, a first-degree family history of dementia, carrying APOE ε4 allele, and being a female, especially after the age of 80 years; among these, the strongest risk factors are advanced age and APOE ε4 allele carrier (Scheltens et al., 2021). ...
... Assessing help-seeking motivation should complement cognitive evaluation. 15 Since knowledge of Alzheimer's disease and the perception of one's own cognitive performance contribute to dementia worries, 16 we also hypothesized that cognitive reserve is associated with greater help-seeking motivation among MCI patients. ...
... For instance, neither Alzheimer's nor Parkinson's disease has specific time frames or markers that clearly indicate when an individual is no longer safe to drive (Hebert, Martin-Cook, Svetlik, & Weiner, 2003;Turner, Liddle, & Pachana, 2017). Accordingly, the literature on driving cessation is dominated by efforts to develop and evaluate measures of driving ability (Bennett, Chekaluk, & Batchelor, 2016;Brown & Ott, 2004;Cameron et al., 2017;Haussmann, Buthut, & Donix, 2017;Piersma et al., 2018). Off-road tests, such as the Clinical Dementia Rating Scale or the Mini-Mental State Examination, have not been found to be sufficient measures of driving performance or risk level to determine when an individual is unsafe to drive (Bennett et al., 2016;Davis & Ohman, 2017). ...