Marcus Shaker’s research while affiliated with Dartmouth–Hitchcock Medical Center and other places

... Food allergies are immune system disorders triggered by protein antigens in food, resulting in a range of clinical symptoms that can affect the gastrointestinal tract, respiratory system, skin, and central nervous system (1). Currently, there is no complete cure for food allergies. ...

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Uncovering the mechanisms underlying the efficacy of probiotic strains in mitigating food allergies: an emphasis on gut microbiota and indoleacrylic acid

... Shared decision-making is an important paradigm of care that touches many aspects of allergy immunology. [42][43][44][45][46][47] This approach to practice engages patients as experts in their own preferences and values, leveraging patient insights with clinician expertise provided by their health-care professional. 42 Importantly, shared decision-making is appropriate under conditions of equipoise. ...

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Anaphylaxis: Definition and criteria

... Given that many of the studies for the role of BM and BE are observational and there are methodological concerns with prospective studies, a recent systematic review concluded there is very low certainty of evidence supporting the safety and efficacy of using milk and egg ladders, or baked and lesser-cooked forms as OIT to promote tolerance to the uncooked form [62]. ...

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Effects of Food Processing on Allergenicity

... The infection control practices questionnaire was adapted from a validated tool (Tahoun et al., 2019) and utilized a 5-point Likert scale ranging from 1 (strongly disagree) to 5 (strongly agree). The questionnaire included items related to hygiene practices such as handwashing, cleaning, food safety, and diaper-changing techniques (11,12). ...

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Assessment of Infection Control Practices Among Caregivers of Daycare Centers

... Early OIT studies have shown more favorable results regarding the development of sustained unresponsiveness in children younger than 4 years [35], and this is confirmed also in studies of epicutaneous immunotherapy (EPIT) [36,37]. Immune system immaturity and plasticity during infancy may be the reason. ...

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New approaches in childhood IgE-mediated food allergy treatment

... 14 clinicians need to be aware of the heterogeneous clinical manifestations of ieis so that early diagnosis and prompt treatment can be engaged, resulting in a better outcome. 15 the potential for discoveries in the field of IEIs is vast, and as our knowledge expands, so will do the possibilities for developing new treatments and management options, eventually improving the Quality of Life for individuals affected by iei but also for patients suffering from highly prevalent polygenic diseases which share the same pathogenetic mechanisms. ...

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Studying inborn errors of immunity to understand the pathogenic mechanisms underlying highly prevalent immune-mediated diseases

... 42 Importantly, shared decision-making is appropriate under conditions of equipoise. 48,49 This fact acknowledges that there are often circumstances in which a strong medical recommendation directs a course of action that is highly likely to result in best health (and sometimes health economic) outcomes. 47 Fortunately, contemporary guidelines provide clear navigational signals for when shared decision-making may be appropriate (i.e., conditional "suggestions") and when clinical circumstances are not preference sensitive (i.e., strong recommendations). ...

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Anaphylaxis: Definition and criteria

... Additionally, the lack of significant variation in patients with prior VZV infection or reactivation or a history of neoplasms is somewhat unexpected. These conditions are generally considered contraindications or complicating factors for initiating treatment with JAK inhibitors [76]. Reactivations of VZV have been solidly documented in RCTs of JAK inhibitors, underscoring the immunosuppressive effects of these therapies [77][78][79]. ...

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Comparative Real-World Analysis of Baseline Demographic Characteristics and Comorbidities in Atopic Dermatitis Patients Initiating Biologics Versus JAK Inhibitors

... Introducing diverse complementary foods during infancy not only supports optimal growth and development but also serves a critical role in immune system maturation [1]. Consequently, the AAP later revised its guidelines, advising against food restrictions and advocating for the early introduction of assorted foods [6,7]. ...

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National Trends and Disparities in Complementary Food Diversity Among Infants: A 12-Year Cross-Sectional Birth Cohort Study

... 8 However, additional real-world clinical data are needed to demonstrate if these desirable outcomes are truly achievable with early age peanut oral immunotherapy (epOIT). 9 This study examines both the effectiveness and safety of peanut OIT in children less than 3 years old at epOIT start in a real-world academic clinical setting and was approved under University of Virginia School of Medicine Approved Protocol (IRB #24604). ...

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Early age peanut oral immunotherapy is safe and effective at achieving desensitization in 27 pediatric patients with peanut allergy