Marco Aurelio Rodriguez-Monroy's research while affiliated with Universidad Nacional Autónoma de México and other places

Publications (35)

Article
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The appearance of antimicrobial-resistant pathogens has highlighted the need to search for new compounds that can effectively combat infectious diseases. A potential source of these compounds are the secondary metabolites of species that have been reported as effective traditional treatments of such diseases. Prosopis laevigata is a medicinal plant...
Article
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The genus Fusarium causes many diseases in economically important plants. Synthetic agents are used to control postharvest diseases caused by Fusarium, but the use of these synthetic agents generates several problems, making it necessary to develop new alternative pesticides. Essential oils can be used as a new control strategy. The essential oils...
Article
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Mangifera indica can generate up to 60% of polluting by-products, including peels. However, it has been shown that flavonoids and mangiferin are mainly responsible for the antioxidant, anti-inflammatory, and antibacterial activities closely related to the wound-healing process. The chemical composition of MEMI (methanolic extract of M. indica) was...
Article
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Fruit and vegetable crops that are not consumed immediately, unlike other agricultural products, require economic and time investments until they reach the final consumers. Synthetic agrochemicals are used to maintain and prolong the storage life of crops and avoid losses caused by phytopathogenic microorganisms. However, the excessive use of synth...
Article
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Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around the world. Nevertheless, there is little information about the activity of propolis in...
Article
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The aim of this work was to evaluate the gastroprotective activity of a Mexican propolis on indomethacin-induced gastric ulcers in a mouse model. The following contents of the ethanolic extract of propolis of Chihuahua (EEPCh) were determined: antioxidant activity (SA50), total phenolic content (TPC), total flavonoid content (TFC), and chemical com...
Article
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Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. Recently, it was shown that the essential oil (EO) of B. morelensis has wound healing activity, accelerating cutaneous wound closure and generating scars with good tensile strength. α-pinene (PIN) and α-phellandrene (FEL) are terpenes that have been found in this EO, a...
Article
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Jatropha neopauciflora is an endemic species of Mexico. Its latex is used to treat wounds, scarring, oral infections, and loose teeth. To date, there are no studies that validate at a morphological level a wound-healing use in diabetes. The present research aimed to evaluate the wound-healing capacity of the latex of J. neopauciflora in the skin of...
Article
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Cyrtocarpa procera is a plant used in traditional Mexican medicine to treat different gastrointestinal problems. Here, we investigated the effects of a C. procera methanolic extract in DSS-induced colitis mice. Ulcerative colitis (UC) was induced by administering 4% DSS in drinking water to female BALB/c mice. Compared to untreated mice with UC, th...
Article
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Bursera morelensis is used in Mexican folk medicine to treat wounds on the skin. It is an endemic tree known as “aceitillo”, and the antibacterial and antifungal activity of its essential oil has been verified; it also acts as an anti-inflammatory. All of these reported biological activities make the essential oil of B. morelensis a candidate to ac...
Article
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Cannabinoid receptor antagonists have been suggested as a novel treatment for obesity and diabetes. We have developed a synthetic cannabinoid receptor antagonist denominated BAR-1. As the function and integrity of a β-cell cellular structure are important keys for diabetes onset, we evaluated the effects of pharmacological administration of BAR-1 o...
Article
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In the Valley of Tehuacan-Cuicatlan, Cyrtocarpa procera and Bursera morelensis are located and are used in traditional medicine. In this research, several biological properties were evaluated. The methanol extracts of C. procera (MeCp) and B. morelensis (MeBm) were obtained by maceration. The antibacterial activities of the extracts were evaluated...
Data
Table 1: mice body weight after administration of the single oral dose of propolis at different concentrations (300, 600, 1200, 24000, and 5000 mg/Kg). Table 2: mice organ weight after administration of the single oral dose of propolis at different concentrations (300, 600, 1200, 24000, and 5000 mg/Kg). Table 3: hematological evaluation and biochem...
Article
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Propolis is a bee-collected natural product that has been proven to have various bioactivities. This study tested the effects of a Mexican propolis on streptozotocin-induced diabetes mellitus in a murine model. The results showed that an ethanolic extract of propolis of Chihuahua (EEPCh) significantly inhibited increases in blood glucose and the lo...
Article
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The candidiasis caused by C. albicans is a public health problem. The abuse of antifungals has contributed to the development of resistance. B. morelensis has demonstrated antibacterial and antifungal activities. In this work the activity of the essential oil of B. morelensis was evaluated and for its two pure compounds with analysis of the differe...
Article
Ethnopharmacological relevance: Jatropha neopauciflora Pax is an endemic species to Mexico, and its latex is used in traditional medicine to treat mouth infections when there are loose teeth and to heal wounds. In this research, we evaluated the antimicrobial activity, wound healing efficacy and chemical characterization of J. neopauciflora latex...
Article
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Background Cutaneous leishmaniasis lacks effective and well-tolerated treatments. The current therapies mainly rely on antimonial drugs that are inadequate because of their poor efficacy. Traditional medicine offers a complementary alternative for the treatment of various diseases. Additionally, several plants have shown success as anti-leishmanial...
Article
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Background Ethnopharmacological relevance. Jatropha neopauciflora (Pax) is an endemic species of the Tehuacan- Cuicatlan Valley, Mexico. This species has long been used as a remedy to alleviate illnesses of bacterial, fungal and viral origin. Aim of the study. Experimentally test the traditional use of Jatropha neopauciflora in Mexican traditional...
Article
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Amphipterygium adstringens is an endemic species in Mexico commonly known as “cuachalalate.” Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined...
Article
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The fruit of Cyrtocarpa procera is used to treat stomach diseases by people living in San Rafael, Coxcatlan, Puebla. This work investigated the antibacterial, antioxidant, cytotoxic and anti-inflammatory activities of the fruit produced by this species. Methanol extract was obtained by maceration. After obtaining the methanol extract (MeOH1), metha...
Article
The free living amoeba Naegleria fowleri is pathogenic to humans but also to other mammalians. These amoebae may invade the nasal mucosa and migrate into the brain causing cerebral hemorrhagic necrosis, a rapidly fatal infection. Knowledge of the cytolytic mechanism involved in the destruction of brain tissues by Naegleria trophozoites is limited....
Article
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We analyzed the possible role of glycoconjugates containing α-D-mannose and α-D-glucose residues in adherence of trophozoites to mouse nasal epithelium. Trophozoites incubated with 20 μg of one of three different lectins which preferentially recognized these residues were inoculated intranasally in Balb/c mice. Mouse survival was 40 % with Pisum sa...
Article
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The bark of Ceiba aesculifolia subsp. parvifolia is used for the treatment of diabetes, kidneys maladies, tumors, gastritis, and wounds by the people of San Rafael, Coxcatlan, Puebla. The aim of this work was to investigate antimicrobial activity, general toxicity, and antioxidant activity of the bark of this species. The methanol extract was obtai...
Article
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Acalypha monostachya (Euphorbiaceae) is used by the inhabitants of San Rafael and Zapotitlan Salinas, Puebla, Mexico, to alleviate illnesses of bacterial and fungal origin. We analyzed the antimicrobial activity of A. monostachya and some of its chemical features. The extracts were obtained by percolation. The antibacterial and antifungal activitie...
Article
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We previously reported that intranasal administration of Cry1Ac protoxin alone or in combination with amoebic lysates increases protection against Naegleria fowleri meningoencephalitis in mice. Those results suggested that both antibody responses and innate immune mechanisms may be participating in the protective effects observed. The present study...
Article
Cry1Ac protoxin from Bacillus thuringiensis is a potent mucosal immunogen and adjuvant. When delivered intranasally (i.n.) Cry1Ac elicits significant antibody response and is able to improve vaccination against Naegleria fowleri infection, but the functional effects occurring in nasal lymphocytes when this protein is administered alone have not bee...
Article
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Viguiera dentata (Cav.) Sprenguel (Asteraceae) is known as “chimalacate” in several Mexican states. Infusions of the aerial part of this species are used for the treatment of baby rash by the inhabitants of San Rafael, Coxcatlan, Puebla, Mexico. We examined the antibacterial and antifungal activities through the disk-diffusion method. The compositi...
Article
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According to previous reports, intranasal administration of the Cry1Ac protein alone or with amoebic lysates increases protection against Naegleria fowleri meningoencephalitis in mice, apparently by eliciting IgA responses in the nasal mucosa. In the current study, we performed an immunohistochemical analysis of IgA in the nasal mucosa of mice immu...
Article
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Free-living ameba Naegleria fowleri produces an acute and fatal infectious disease called primary amebic meningoencephalitis (PAM), whose pathophysiological mechanism is largely unknown. The aim of this study was to investigate the role of nitric oxide (NO) in PAM. Although NO has a cytotoxic effect on various parasites, it is produced by others as...
Article
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Nasal-associated lymphoid tissue (NALT) and nasal passages (NP) are considered as inductive and effector sites, respectively. The differences among lymphocyte populations of these nasal compartments have not been clearly established. The aim of this work was to contribute to the characterization of NALT and NP lymphocytes in mice. We isolated lymph...
Article
Cry1Ac from B. thuringiensis is a potent mucosal immunogen and adjuvant. Via i.n. route Cry1Ac induces significant antibody responses and is able to improve vaccination against nasal invading pathogens, but their effects on nasal lymphocytes have not been determined. NALT and NP are considered as inductive and effector sites, respectively. We inves...
Article
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Specific anti-Acanthamoeba IgA antibodies have been detected in the serum and tears of patients and healthy individuals. However, the role of human secretory IgA antibodies in inhibiting the adherence of Acanthamoeba had not been previously investigated. Therefore, the purpose of this study was to purify secretory IgA from human colostrum and analy...
Article
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The initial stages of Naegleria fowleri meningoencephalitis in mice were immunohistochemically characterized following the first 8 h post-intranasal inoculation. The events found after 8 h were: (1) amebas in contact with the mucous layer of the olfactory epithelium, (2) numerous parasites eliminated by extensive shedding of the mucous layer, and (...
Article
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Cry1Ac protoxin has potent mucosal and systemic adjuvant effects on antibody responses to proteins or polysaccharides. In this work, we examined whether Cry1Ac increased protective immunity against fatal Naegleria fowleri infection in mice, which resembles human primary amoebic meningoencephalitis. Higher immunoglobulin G (IgG) than IgA anti-N. fow...

Citations

... and g-eudesmol (VIP=1.15). This identification of chemical markers exhibited a wide range of antimicrobial properties and applications in various commercial preparations, such as plant pathogens, food spoilage bacteria, and foodborne pathogens, which have been examined by many researchers (Haznedaroglu et al., 2001;Benali et al., 2020;Medina-Romero et al., 2022). ...
... Extracts rich in phenolic compounds from Diospyros mespiliformis, Haplophyllum tuberculatum, and Mangifera indica showed important antioxidant, anti-inflammatory, and antimicrobial activities when evaluated in different models of wound healing [106][107][108]. Rocha et al. [109] evaluated the antioxidant, anti-inflammatory, and healing activities of Artemisia campestris L. hydrodistillation residual water and its essential oil, finding that the residual hydrodistillation water showed promising antioxidant and anti-inflammatory activities without causing toxicity in the macrophages and fibroblasts. ...
... There are numerous abiotic conditions that cause essential oils to degrade quickly (making their handling easy since there are no residue problems). They offer a broad spectrum of activity are simple to process and utilize as they are less persistent, making them safe for people and the environment [64]. The application of EOs in more environmentally sustainable agronomic techniques has been the subject of numerous research investigations. ...
... Propolis is a complex bee product with diverse biological activities that are determined by its variable chemical composition [17,23,36,[47][48][49][50][51]. This, in turn, depends on different factors such as the geographical region in which it is collected, the surrounding flora, and the bee species that produces it [50,52,53]. ...
... Nowadays, α-phellandrene has been characterized by a broad spectrum of pharmacological activities, including antimicrobial, anti-inflammatory, antitumoral, analgesic, and insecticidal activities (Figure 4) [60][61][62][63]. Alpha-phellandrene accelerated wound closure due to collagen deposition and demonstrated good wound-healing properties [64][65][66]. In addition, α-phellandrene is associated with enhancement of the proliferation of vascular endothelial growth factor in dermal papilla cells, which indicates that α-phellandrene has a strong potential to prevent hair loss [67]. ...
... Many members of the genus were used medicinally in their indigenous countries such as J. gossypifolia, J. curcas, J. chevalieri, and J. multifida [3]. Leaves and latex from Jatropha plants are especially useful in treating skin conditions such as ulcers, blisters, eczema and also to accelerate wound healing [4][5][6]. The genus is rich in bioactive secondary metabolites especially diterpenoids of tigliane, lathyrane, and jatrophane skeletons which exist mainly as esters [7,8]. ...
... The observed activities might be associated with the presence of diverse phytoconstituents, among them phenolic acids (Protocatechuic acid glucoside, (neo)chlorogenic acid, 4hydroxybenzoic acid glucoside, chlorogenic acid, and vanillic acid glucoside), coumarins (Aesculetin and its glucoside derivative), dihydrochalcones glucosides (Phloretin glucoside, phloretin pentosylglucoside, and phlorizin) and flavonoids (Kaempferol, quercetin and their mono and dimer glycosides). These results are in agreement with those reported from other extracts containing polyphenolics such as Syzygium samarangense [10], apple [35,36], Chihuahua propolis [37] and Euphorbia umbellata (Pax) Bruyns [38]. Several individual components furnished similar activities as well. ...
... For example, in a murine model of chronic colitis, the administration of the methanolic extract of Cyrtocarpa procera (C. procera), a plant used in traditional Mexican medicine, decreased the clinical symptoms associated with colitis as well as the levels of chronic inflammation [63]. In addition to C. procera, several traditionally used plants have shown cytotoxic activity in human CRC cell lines in vitro (Figure 3b) [61]. ...
... The migration of fibroblasts into the wound bed and the formation of an extracellular matrix of granulation tissue is another feature of wound healing [109]. The essential oil of Bursera morelensis promoted fibroblast migration to the wound site and initiated collagen synthesis [110]. α-pinene and α-PHE treatments showed wound-healing activity, with improved scar tissue and collagen deposition [34]. ...
... 66,67 In the last decades two different CB1 receptor antagonists have been synthetized, BAR-1 and Ibipinabant. 42,[68][69][70] In isolated pancreatic islets from rats, BAR-1 increased insulin, glucokinase, PDX-1 and CB1r gene expression, and basal insulin secretion was modified, in opposition to AEA effect. 42 BAR-1 treatment of prediabetic and diabetic mice reduced oral glucose tolerance without effect on HbA1c and triglycerides; glucosestimulated insulin secretion was enhanced, but gene expression for insulin, glucagon, PDX-1 and some elements of ECS showed significant decrease. ...