Marcele Lorentz Mattos de Souza's research while affiliated with Universidade Federal do Espírito Santo and other places
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Publications (3)
Introduction: Psychiatric disorders have become a global problem that leads millions of people to use psychotropic medications, especially benzodiazepines. The effects of these substances are widely known regarding tolerance and chemical dependence, however, from epigenetics perspective, there are still little known. Objective: To evaluate the asso...
This study aimed to investigate BDNF gene methylation in individuals with depression based on tobacco use. Therefore, 384 adults from southeastern Brazil were recruited to assess depression, socioeconomic status, lifestyle, and methylation by pyrosequencing exon IV promoter region of the BDNF gene. The Generalized Linear Model (GzLM) was used to ch...
Aims
the present study aimed to investigate how glucose and insulin levels may be associated with changes in NR3C1 gene methylation levels in adults.
Main methods
375 volunteers users of the Brazilian Public Unified Health System (SUS) were recruited to assess socioeconomic status, lifestyle, anthropometric data, blood glucose and serum cortisol l...
Citations
... Regarding the clinical investigations, most of them utilised valproic acid/sodium valproate (VPA), which is an HDACi. Most of these studies reported that VPA has anxiolytic effects in ADs patients, and thus, it can be used in the treatment of patients suffering from ADs. VPA may affect chromatin shape and epigenetic markers [122][123][124][125][126]. In particular, class I HDACs, which encourage histone acetylation, are inhibited by lysine 9 of histone H3 and lysine 8 of histone H4. ...
Reference: The role of epigenetics in anxiety disorders
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... Notably, the same brain region contains a vast range of neuronal types that are classified by morphological, anatomical, and physiological features. [26,27] The function underlying depressive function in mouse model [28][29][30] Response to antidepressants [20,[31][32][33][34] Anxiety-like behaviors [28,29] Cocaine reward-seeking behavior [17] Relations with nicotine addiction in human beings [35,36] Circadian rhythm [22] Sleep regulation and NREM sleep [37] VI Spatial memory reversal and Contextual memory extinction [38] Dendrites localization and Distal dendritic development [24] Relations with schizophrenia patients [21] Schizophrenia-like phenotypes in mice [11] To investigate the function of specific Bdnf promoters, our group (Dr. Bai Lu and colleagues) generated mouse lines, named Bdnf -e1 −/− , e2 −/− , e4 −/− , and e6 −/− mice, in which Bdnf Promoters I, II, IV, and VI were selectively disrupted. ...
... However, there were no methylation differences between the buffy coats of individuals with and without MetS in the CpGs evaluated for the 1F region, even though the expression of these genes is similar in blood and hypothalamus. Although no association studies of MetS with NR3C1 differential methylation were found in the literature, variations in its methylation patterns have been observed for related comorbidities, such as cardiovascular diseases [22], subclinical arteriosclerosis (hypermethylation of the 1F promoter, in a study with monozygotic twins) [66], overweight (hypomethylation of the 1F region, CpGs 40 to 47) [51], unfavorable prognosis for coronary acute syndrome in individuals with depression (hypermethylation of exon 1F) [67], blood pressure (hypermethylation of 1F and 1H promoters associated with lower blood pressure) [68], and a positive association between methylation and glucose levels as well as insulin resistance [69]. Considering the multiple alternative first exons and their variability in tissue-specific expression, and that each of these exons has its own active promoter, DNA methylation and other epigenetic mechanisms should be evaluated in other regions. ...
