Manuel Graña’s research while affiliated with University of the Basque Country and other places

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Publications (503)


Fig. 1. Macular areas of the ganglion cell layer (GCL), inner plexiform layer (IPL), retinal nerve fiber layer (RNFL) and peripapillary areas of the Retinal Nerve Fiber Layer (pRNFL) that showed significant thinning in patients with bipolar disorder vs healthy participants after Random Forest analysis. AUC > 0.8 F1 > 0.7 Test Accuracy > 0.7.
Fig. 2. Upper panel Fig. 2a: Significant thinning areas of the macular ganglion cell layer (GCL), inner plexiform layer (IPL), retinal nerve fiber layer (RNFL), and apillary retinal nerve fiber layer (pRNFL) associated with lower Stroop test performance by BD group identified by Random Forest. Test Accuracy AUC and F1 > 0.7. Lower panel Fig. 2b: Significant thinning areas of the macular ganglion cell layer (GCL), inner plexiform layer (IPL), retinal nerve fiber layer (RNFL), and peripapillary retinal nerve fiber layer (pRNFL) associated with lower Wisconsin test performance by BD group identified by Random Forest. Test Accuracy > 0.7 AUC > 0.8 and F1 > 0.7.
Sociodemographic outcomes of the sample.
Retinal thickness: A window into cognitive impairment in bipolar disorder
  • Article
  • Full-text available

March 2025

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1 Citation

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Manuel Graña

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https://www.sciencedirect.com/science/article/pii/S2950285325000043?dgcid=coauthor

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Comment on Uzun Ozsahin et al. COVID-19 Prediction Using Black-Box Based Pearson Correlation Approach. Diagnostics 2023, 13, 1264

November 2024

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15 Reads

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1 Citation

The declaration of the COVID-19 pandemic by the World Health Organization (WHO) in March 2020 has triggered the publication of thousands of papers covering a plethora of aspects of the pandemic, from epidemiology models [...]


Older Adult Fall Risk Prediction with Deep Learning and Timed Up and Go (TUG) Test Data

October 2024

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121 Reads

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1 Citation

Falls are a major health hazard for older adults; therefore, in the context of an aging population, predicting the risk of a patient suffering falls in the near future is of great impact for health care systems. Currently, the standard prospective fall risk assessment instrument relies on a set of clinical and functional mobility assessment tools, one of them being the Timed Up and Go (TUG) test. Recently, wearable inertial measurement units (IMUs) have been proposed to capture motion data that would allow for the building of estimates of fall risk. The hypothesis of this study is that the data gathered from IMU readings while the patient is performing the TUG test can be used to build a predictive model that would provide an estimate of the probability of suffering a fall in the near future, i.e., assessing prospective fall risk. This study applies deep learning convolutional neural networks (CNN) and recurrent neural networks (RNN) to build such predictive models based on features extracted from IMU data acquired during TUG test realizations. Data were obtained from a cohort of 106 older adults wearing wireless IMU sensors with sampling frequencies of 100 Hz while performing the TUG test. The dependent variable is a binary variable that is true if the patient suffered a fall in the six-month follow-up period. This variable was used as the output variable for the supervised training and validations of the deep learning architectures and competing machine learning approaches. A hold-out validation process using 75 subjects for training and 31 subjects for testing was repeated one hundred times to obtain robust estimations of model performances At each repetition, 5-fold cross-validation was carried out to select the best model over the training subset. Best results were achieved by a bidirectional long short-term memory (BLSTM), obtaining an accuracy of 0.83 and AUC of 0.73 with good sensitivity and specificity values.


Figure 6. ROC curve with Point-wise Confidence Bounds of an instance of the 5-fold cross-validation of the BILSTM architecture. The dashed lines represent the chance ROC.
Descriptive statistics of the spatiotemporal measurements of the TUG test realizations corresponding to standing phase, sitting phase and rotations body trunk kinematics (flexion and/or
Average test performance results after 100 repetitions of hold-out cross-validation of different classifiers for sets of features extracted from the TUG test phases enumerated in Table 1.
Average test performance results after 100 repetitions of hold-out cross-validation for the 1D CNN architectures.
Average test performance results after 100 repetitions of hold-out cross validation for the LSTM architectures.
Older Adult Fall Risk Prediction with Deep Learning and Timed Up and Go (TUG) Test Data

September 2024

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25 Reads

Falls are a major public health problem among older adults, therefore predicting the risk of having falls in the near future is of great importance for health and social systems worldwide. Nowadays, prospective fall risk assessment relies on clinical and functional mobility assessment tools, such as the Timed Up and Go (TUG) test. Recently, wearable inertial measurement unit (IMU) sensors measurements have been proposed for fall detection. We hypothesize that the IMU readings captured during TUG test realizations can provide prospective fall risk prediction. In this study, analysis by deep learning convolutional neural networks (CNN) and recurrent neural networks (RNN) were used for fall prediction based on features extracted from IMU data acquired during TUG test realizations. Data is obtained from a cohort of 106 older adults wear-ing a wireless inertial sensor with a sampling frequency of 100 Hz while performing the TUG test. Prospective fall incidence was obtained in a six-month follow-up period and used as the ground truth for the supervised training and validations of the deep learning and competing machine learning approaches. Further data collection could lead to potential fall risk biomarker. A repeated hold out cross-validation process using 75 subjects for training and 31 subjects for testing was carried out. Best results were achieved by a bidirectional long short-term memory (BLSTM), obtaining an accuracy of 0.83 and AUC of 0.73 with good sensitivity and specificity values.



Artificial Intelligence Applied to Drone Control: A State of the Art

July 2024

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1,820 Reads

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31 Citations

The integration of Artificial Intelligence (AI) tools and techniques has provided a significant advance in drone technology. Besides the military applications, drones are being increasingly used for logistics and cargo transportation, agriculture, construction, security and surveillance, exploration, and mobile wireless communication. The synergy between drones and AI has led to notable progress in the autonomy of drones, which have become capable of completing complex missions without direct human supervision. This study of the state of the art examines the impact of AI on improving drone autonomous behavior, covering from automation to complex real-time decision making. The paper provides detailed examples of the latest developments and applications. Ethical and regulatory challenges are also considered for the future evolution of this field of research, because drones with AI have the potential to greatly change our socioeconomic landscape.





Citations (48)


... Psychiatric disorders, particularly MDD, are often associated with increased risk of cardiovascular disease, and endothelial dysfunction is a common finding in these patients. Systemic inflammation, a key feature of psychiatric disorders, can contribute to this widespread endothelial dysfunction, affecting both the cerebral and retinal microvasculature.[16][17][18][19][20] ...

Reference:

The Eye as a Window to Neuroinflammation in Psychiatric Disorders?: A Meta-Analysis of Retinal Structural and Vascular Biomarkers
Retinal thickness: A window into cognitive impairment in bipolar disorder

... The Timed Up and Go (TUG) test analyzed functional mobility parameters. This test quantifies, in seconds, the time it takes for an individual to perform a task consisting of standing up from a standardized chair without armrests, walking three meters, turning around, walking back toward the chair, and sitting down again (Maiora et al. 2024). Subjects were instructed to perform the test at a self-selected, safe pace to avoid the risk of falling. ...

Older Adult Fall Risk Prediction with Deep Learning and Timed Up and Go (TUG) Test Data

... It is expected that continued advancements in these technology fields will improve drone operations even more in the near future. (Caballero-Martin et al.,2024) Obstacle avoidance is emphasized as a critical component of autonomous quadrotor navigation, especially in dynamic environments where there is a chance of collisions because of moving obstacles or meteorological conditions. The study outlines the development of three main classes of algorithms relevant to self-governing behavior: perception, planning, and control. ...

Artificial Intelligence Applied to Drone Control: A State of the Art

... QR codes can be integrated into data processing apps across various sectors: 1. Healthcare: QR codes can facilitate patient data management, appointment scheduling, and medication tracking (Badiola-Zabala et al., 2024). An app designed for healthcare professionals could streamline these processes by allowing quick access to patient records via QR code scanning. ...

Machine Learning First Response to COVID-19: A Systematic Literature Review of Clinical Decision Assistance Approaches during Pandemic Years from 2020 to 2022

... Graph Neural Networks (GNNs) are particularly intriguing for EEG data as they can model the connectivity between different brain regions. By considering the graph structure of the brain, GNNs may reveal how emotional information is processed across the brain network [19]. Autoencoders also demonstrate great potential in dimensionality reduction and feature extraction. ...

A review of Graph Neural Networks for Electroencephalography data analysis
  • Citing Article
  • October 2023

Neurocomputing

... Conventional techniques are susceptible to human error, labor intensive, and typically offer limited scalability. Compared with DL, it can process vast quantities of data obtained from advanced sensors and vision systems in real-time, facilitating the identification of subtle behavioral patterns that may otherwise be overlooked by human observers Aguilar-Moreno and Graña, 2023). Nevertheless, traditional methods possess certain advantages in terms of interpretability and do not require the same degree of computational infrastructure. ...

Computational Ethology: Short Review of Current Sensors and Artificial Intelligence Based Methods
  • Citing Chapter
  • June 2023

Communications in Computer and Information Science

... B. Fernandez-Gauna, N. Rojo, M. Graña studied the process of evaluating team coding tasks based on DevOps technologies [1]. They developed a system for automating the evaluation of team tasks and a methodology for its use. ...

Automatic feedback and assessment of team-coding assignments in a DevOps context

International Journal of Educational Technology in Higher Education

... The purpose of this restriction is allowing the model to function in a municipality driven telemonitoring setup, that might not have access to further patient data. One study used a similar approach but augmented daily biometric measurements with patient reported Table 2 Characteristics of the included patients health outcomes, the study achieved a ROC-AUC of 0.694 [43], which is slightly higher than our best model -indicating that daily measurements or patient reported outcomes, might increase predictive performance. We found that more complex models showed worse performance than the Lasso regression, indicating that the traditional tradeoff of interpretability versus performance, might be of less relevance in the context of chronic heart failure patients. ...

Prediction and Analysis of Heart Failure Decompensation Events Based on Telemonitored Data and Artificial Intelligence Methods

... One particularly promising avenue for RAG in finance lies in tasks that require synthesizing multiple data sources to generate accurate and timely insights. Credit evaluation and risk management heavily rely on diverse and evolving information, including borrower transaction histories, macroeconomic indicators, alternative credit scoring data, and regulatory filings (Bhattacharya et al., 2023;Kedia & Mishra, 2024;Muñoz-Cancino et al., 2023;Feng et al., 2023a). Traditional models often struggle to incorporate and interpret such heterogeneous data in real time (Kalapodas & Thomson, 2006;Faheem, 2021;Bello, 2023), but RAG can dynamically retrieve relevant external documents and integrate them with proprietary financial records to improve decision-making accuracy. ...

On the dynamics of credit history and social interaction features, and their impact on creditworthiness assessment performance
  • Citing Article
  • May 2023

Expert Systems with Applications