Manav Vadhera’s scientific contributions

Background: Over decades, increased demand of platelet transfusions for patients with various medical and surgical diagnoses led to accelerated usage of technologically advanced "Apheresis" for platelet concentrates which is conducted under the transfusion medicine specialist's supervision in special dedicated areas. Hence; the present study was conducted with the aim of assessing adverse events associated with apheresis procedures. Materials & methods: A total of 500 apheresis procedures were analysed in the present study. Complete demographic details of all the patients were obtained. A Performa was designed and complete details were recorded in it. All adverse events were recorded by the staff. The adverse events occurring during or after the procedures were classified as vascular injuries (VIs), citrate reaction (CR), presyncopal/syncopal (PS/S), and PS + CR both. All the results were recorded and analysed using SPSS software. Results: Overall, vascular injuries were seen in 4 patients while citrate reaction was seen in 3 patients. Among vascular injuries, 2 adverse reactions were seen during procedure while the remaining 2 cases were seen after procedure. Conclusion: Apheresis donations have very less fraction of acute reaction rates which are relatively mild and easily treated.

Background: Transfusion reactions are defined as adverse events associated with the transfusion of whole blood or one of its components. Hence; the present study was conducted for evaluating adverse transfusion reactions following blood product transfusion. Materials & methods: The present study was conducted for evaluating adverse transfusion reactions following blood product transfusion. A retrospective survey was carried out. All the demographic and clinical details of all the patients were obtained. A Performa was made and type of blood products transfused was recorded separately. Follow-up records of all the patients were evaluated and occurrence of transfusion reaction was noted on excel sheet. Results: A total of 890 blood products were transfused. Among these, red blood cells, platelet rich plasma and fresh frozen plasma were transfused in 423, 325 and 142 cases respectively. Febrile non-haemolytic transfusion reaction, Non-immune haemolysis, Allergic reactions and anaphylactic reactions were seen in 25, 3, 17 and 2 cases respectively. Conclusion: Febrile non-haemolytic transfusion reaction and Allergic reactions were the most common adverse events seen in patients receiving blood transfusion.

Background: Anaemic patients frequently proceed to surgery without considered assessment and management of this risk factor for adverse outcome. Hence; the present study was conducted with the aim of assessing the effect of Anaemia on recovery in surgical patients. Materials & methods: 100 anaemic patients were randomly enrolled in the present study. Complete demographic and clinical details of all the patients were obtained. Thorough history of all the patients was recorded. The line of treatment was also recorded. Haemoglobin estimation was done by Acid haematin method and according to haemoglobin patients were divided in mild, moderate and severe. Recovery profile of all the patients was assessed. Results: Mean hospital stay among patients with haemoglobin levels of Less the 6 gm% was 29.4 days while among patients with haemoglobin levels between 6 to 8.99 gm%, mean hospital stay was 21.8 days. Mean hospital stay among patients with haemoglobin levels between 9 to 10.99 gm% and between 11 to 12.5 gm% was 12.3 days and 8.5 days respectively. Significantly longer hospital stay days were associated with patients with more severe degree of anaemia. Conclusion: Severity of Anaemia affects the recovery profile in surgical patients.