Majid Ghaffarpour's research while affiliated with Tehran University of Medical Sciences and other places

Publications (56)

Article
Background Fatigue is one of the most common symptoms in patients with multiple sclerosis (MS). Currently, there is no approved medication for MS-related fatigue. Objective In this study, we aim to evaluate the safety and efficacy of memantine for improving fatigue in patients with MS. Methods This was a pilot randomized, double-blind, placebo-co...
Article
Full-text available
Background: Epidemiological evidence suggests a role of Epstein-Barr virus (EBV) in triggering the pathogenesis of Multiple Sclerosis (MS). The aim of this study was to assess the EBV-specific antibodies in MS patients with various clinical patterns and their association with the production of IFN-γ, IL-12, and IL-4 cytokines compared with healthy...
Article
Full-text available
Background and aim Vascular dementia (VaD) is the second most common cause of dementia and currently there is scarcity of therapies for VaD. We aimed to investigate the efficacy and safety of MLC601 in the treatment of VaD. Methods In this multicenter, pilot, randomized, double-blind trial, 82 patients with VaD according to DSM-5 criteria received...
Article
Full-text available
Background: To date, magnesium sulphate (MgSO4) is the treatment of choice for prevention of seizure in eclampsia and preeclampsia. However, there are some limitations in the administration of MgSO4 due to its tocolytic effects. The aim of this study was to compare the anticonvulsant and tocolytic effects of MgSO4 and another drug, phenytoin, in pa...
Article
Context Fatigue is one of the most common and disabling symptoms in Multiple Sclerosis (MS). Aims We aimed to evaluate the effects of low dose Aspirin (80 mg) in primary fatigue in MS patients. Settings and design This is a single-center, randomized, double-blind and parallel trial with 1:1 ratio allocation of two treatment groups of low dose Asp...
Article
The purpose of this study was to compare the specific activity of proteinase A in Candida albicans (C. albicans) between multiple sclerosis (MS) patients and controls. A total of 135 and 100 C. albicans strains were isolated from superficial surfaces of MS patients and healthy controls. Analytical models (regression and neural network) were applied...
Article
Background: Uncontrolled studies in human have suggested that memantine might be a suitable option for migraine prophylaxis. Objective: To assess the efficacy and tolerability of memantine for migraine prophylaxis. Methods: This was a 12-week randomized double-blind placebo-controlled parallel-group study. Sixty patients with migraine without...
Article
Full-text available
Objective: Multiple sclerosis (MS) is one of the leading neurodegenerative causes of physical disability world-wide. Genetic aberrations of autoimmunity pathway components have been demonstrated to significantly influence MS development. Cluster of Differentiation 58 (CD58) is pertained to a group of genes which had been assayed in several recent...
Article
Background Posterior reversible encephalopathy syndrome (PRES) is a well-recognized complication of hypertensive encephalopathy. Recently, pre-eclampsia, connective tissue disorders, and immunosuppressive drugs have been reported to be the etiologies of this rare syndrome. Methods We evaluated 9 cases of PRES whose diagnosis were confirmed based on...
Article
Full-text available
Background and Purpose The aim of this study was to determine the efficacy and tolerability of granulocyte colony-stimulating factor (G-CSF) in subjects with amyotrophic lateral sclerosis (ALS). Methods Forty subjects with ALS were randomly assigned to two groups, which received either subcutaneous G-CSF (5 µg/kg/q12h) or placebo for 5 days. The su...
Article
Cerebral hyperperfusion syndrome, known as dark side of carotid recanalization, happens in about 0-3% of patients. Unfortunately, physicians involving in carotid recanalization generally aren’t aware of diagnostic and therapeutic aspects of this unusual but potentially life-threatening disorder. Severe bilateral carotid stenosis is suggested to pre...
Article
Full-text available
Sarcoidosis is a multisystem noncaseating granulomatous disease with a propensity for lung, eye, and skin which recently have been proposed that mycobacterium tuberculosis may contribute in its pathogenesis, and rarely involves central nervous system (CNS). Despite CD4+ lymphocytopenia, sarcoidosis by itself does not increase risk of opportunist...
Article
Full-text available
Month-long daytime Ramadan fasting pose s major challenges to multiple sclerosis (MS) patients in Muslim countries. Physicians should have practical knowledge on the implications of fasting on MS. We present a summary of database searches (Cochrane Database of Systematic Reviews, PubMed) and a mini-symposium on Ramadan fasting and MS. In this sympo...
Article
Full-text available
Context: Seizure is a transient neurologic dysfunction caused by sudden abnormal firing of cerebral neurons. Epileptic syndrome is a complex of symptoms and signs that is characterized by not only the etiology but also the age at onset, seizure type, pattern of electroencephalography and prognosis. Evidence Acquisition: Treatment of the first seizu...
Article
Full-text available
We aimed to compare the association of high-sensitivity C-reactive protein (CRP) and National Institutes of Health Stroke Scale (NIHSS) score with mortality risk and to determine the optimal threshold of CRP for prediction of mortality in ischemic-stroke patients. A series of 162 patients with first-ever ischemic-stroke admitted within 24 h after o...
Article
Full-text available
Background: N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are frequently elevated in patients with acute ischemic stroke. This study investigated whether the baseline NT-proBNP level on admission can predict short-term mortality after ischemic stroke. Methods: One hundred patients with acute ischemic stroke underwent thorough clinical...
Article
Full-text available
The new-AEDs, whose developments were motivated following the discovery of the valproate and its marketing in the U.S in 1978, have presented more therapeutic options. There are approximately twenty four FDA-approved antiepileptic drugs for use in patients with epilepsy, five of which were identified and have come on to the market between 2009 and...
Article
Objectives: The aim of the current study was to design a new simpler form of National Institutes of Health Stroke Scale (NIHSS) for use in emergency settings, and compare its predictive ability with original NIHSS score for mortality. Methods: A total of 152 consecutive patients with first ever ischemic stroke admitted to a university affiliated...
Article
Conditioned place preference (CPP) has been associated with orexinergic (hypocrtinergic) system activation in naïve mice; however, the distinct role of different receptors of orexin in this paradigm has not been characterized yet. Moreover, the relationship between orexins and morphine in dependent mice may not be equal to naïve mice and seems note...
Article
Full-text available
High sensitive C-reactive protein (hs-CRP) is a systemic inflammatory marker that is produced in a large amount by hepatocytes in response to interleukin-1 (IL-1), IL-6 and tumor necrosis factor after ischemic stroke. Measurement of hs-CRP in the first 24 hours of onset in 162 patients suffering from ischemic stroke was done. Relation of CRP with t...
Article
Full-text available
Numerous etiologies are responsible for cases of stroke in young adults. This study reviews the causes of two types of stroke (ischemic and intracerebral hemorrhage) in young adults aged 15 to 40 years, admitted to our center (a tertiary care center) from 1997 to 2002. The purpose of this study is to determine the relative frequency of causes of st...
Article
Full-text available
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system. Evidences linking apolipoprotein E (APOE) to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggest that it may be relevant in MS. The main goal of this study was to determine whether the APOE genotypes and alleles are as...
Article
Background: we evaluated the diagnostic value of Electroencephalography (EEG), video-EEG monitoring (VEM) and Magnetic resonance imaging (MRI) of the brain with epilepsy protocol in patients with complex partial epilepsy.Methods: Forty-two consecutive patients underwent complete neurological examination, EEG, and MRI with a modified epilepsy protoc...
Article
Full-text available
The underlying structure of National Institutes of Health Stroke Scale (NIHSS) as the most widely used scale in clinical trials has been the focus of little attention. The aim of the current study was to elucidate the clustering pattern of NIHSS items in ischemic stroke patients. A series of 152 consecutive patients with first-ever ischemic strokes...
Article
Full-text available
Abstract: Primary angiitis of the central nervous system (PACNS) is an idiopathic disorder (vasculitis) restricted to the central nervous system (CNS). It often presents with focal neurological deficits suggesting stroke or a combination of confusion and headache. We herein report three cases with various combinations of fever, partial seizure, en...
Article
To compare the sympathetic skin responses (SSRs) in patients with multiple sclerosis (MS), clinically isolated syndrome (CIS), and healthy controls. SSR was recorded on both hands and feet in 30 patients and 20 healthy controls. SSR results (latency measurements) were compared in patients with normal or abnormal brainstem auditory evoked potentials...
Article
Fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-A (PDGF-AA) are potent modulators of oligodendrocytes, the main responsible cells for myelin regeneration. We measured FGF-2 and PDGF-AA in the sera and cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (RR-MS) and compared these values with contro...
Article
Full-text available
This study determines the value of linkage analysis using six RFLP markers for carrier detection and prenatal diagnosis in familial DMD/BMD cases and their family members for the first time in the Iranian population. We studied the dystrophin gene in 33 unrelated patients with clinical diagnosis of DMD or BMD. Subsequently, we determined the rate o...
Article
Full-text available
We evaluated the diagnostic value of Electroencephalography (EEG), video-EEG monitoring (VEM) and Magnetic resonance imaging (MRI) of the brain with epilepsy protocol in patients with complex partial epilepsy. Forty-two consecutive patients underwent complete neurological examination, EEG, and MRI with a modified epilepsy protocol. A subset of thes...
Article
Full-text available
Background:Multiple sclerosis(MS) is the most common autoimmune disease of central nervous system with destruction of myelin sheath mediated by auto reactive CD4+ T Lymphocytes. Because of the possible role of Epstein-Barr virus in etiology of MS and T cells immune response, the aim of this study was to evaluate anti-Epstein Barr virus antibodies a...
Article
Background: Recent studies present a high prevalence of multiple sclerosis (MS) in Iran. Treatment with interferon is now the first choice in management of MS. CinnoVex™ (an interferon beta 1-a) is available in Iran, with achievement of the technology of producing beta interferon. The aim of the present study is to evaluate the efficacy and safety...
Article
Full-text available
Oxidative stress through the changes in the levels of reactive oxygen species and antioxidative parameters can cause various neurological disorders. The aim of the present study was to show antioxidant activity (AOA) and malondialdehyde (MDA) levels in affected people with Guillain-Barre syndrome (GBS) and multiple sclerosis (MS). A total of 15 GBS...
Article
There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e.g. by SSRIs) has been reported to be anticonvulsant. This study was performed to determine the effect of selective 5-HT(3) channel/receptor antagonist granisetron and a...
Article
Full-text available
Caveolin 1 (CAV1) is a component of the myelin sheath and the expression of the gene encoding this protein is increased during myelination in Schwann cells and oligodendrocytes. We sought to investigate the homozygote haplotype compartment in a recently identified polymorphic purine complex at the upstream region of the human CAV1 gene in multiple...
Article
Caveolin 1 (CAV1) is a component of the myelin sheath and the expression of the gene encoding this protein is increased during myelination in Schwann cells and oligodendrocytes. We sought to investigate the homozygote haplotype compartment in a recently identified polymorphic purine complex at the upstream region of the human CAV1 gene in multiple...
Article
Full-text available
Among the causes of headache, cerebral venous and/or dural sinus thrombosis (CVT) is an important challenge because of its variable clinical presentation, having negative brain CT in up to 30% of cases and unavailability of MRI in some situations. On the other hand as D-Dimer (DD) test has been reported to be a sensitive test for the exclusion of v...
Article
Full-text available
Acute idiopathic peripheral facial paralysis (Bell's palsy) is the most common disorder of the facial nerve. Most patients recover completely, although some have permanent disfiguring facial weakness. Many studies have attempted to identify an infectious etiology for this disease. Although the cause of Bell's palsy remains unknown, recent studies s...
Article
Full-text available
There are conflicting reports about EEG findings of the migraineurs. In this study we report the ictal and interictal EEGs of 100 migraineurs in comparison with control group. The age range for patient and control groups were 9-48 and 10-46 years, respectively; 32% of the patients were less than 14 years old and the remaining 68% were more than 14...
Article
Full-text available
Cognitive impairment may be a common even at the onset of multiple sclerosis (MS). In this case-control study, we tried to find out the probable relationship between homocysteine levels and cerebral atrophy or cognitive impairment in patients with multiple sclerosis. One hundred fifty six patients who had MS according to McDonald diagnostic criteri...
Article
Full-text available
Brucellosis is an endemic infectious disease in our country. Neurobrucellosis occurs in 5 to 10% of cases, and can present at any stage of acute or chronic phases of the disease. This study was undertaken to evaluate clinical, epidemiological and paraclinical aspects of brucellosis with and without neurological manifestations. Data of 30 patients,...
Article
Full-text available
Human infection with echinococcus granulosis is a common disease throughout south America, The Mediterranean littoral, The Middle East, Central Asia and East Africa, which usually occur in children and young adults. Formation of avascular cystic lesions in the liver, kidney, pancreas, bones, vitreus and brain can cause protean of signs and symptoms...
Article
Full-text available
Adverse effects of antiepileptic drugs including cutaneous reactions may not only affect the result of treatment and quality of life, but can also be fatal if severe. Skin rash is more likely to occur during the first few months of treatment. The objective of this study was description of skin rashes in users of four antiepileptic drugs. We identif...
Article
Full-text available
Oligoclonal bands (OCB) can be detected in a significant percentage (90%) of patients with multiple sclerosis (MS), however, a much lower percentage has been reported in some studies, mainly from oriental countries. On the other hand, OCB have been detected in other neurological disorders (OND), even in diseases without any definite evidence for in...
Article
Full-text available
Lamotrigine has been used widely in the treatment of partial and secondary generalized seizures. In this study use of lamotrigine as monotherapy for the newly diagnosed primary generalized tonic-clonic seizure has been investigated and compared with carbamazepine. After dose escalation (3 weeks for carbamazepine and 6 weeks for lamotrigin), patient...
Article
Full-text available
Primary hypokalemic periodic paralysis is a familial channelopathy inherited as an autosomal dominant trait. The first attack of paralysis may be evolved at any age, but has been reported to be most common in the second decade, so that some authorities believe that an episodic weakness beginning after age 25 is almost never due to primary periodic...
Article
Full-text available
Footdrop is a relatively common deficit among the neurological disorders, which has different causes with various levels of involvement in neuromuscular system, including central nervous system (brain cortex, spinal cord), fifth lumbar root, peripheral nerves and muscles. Peroneal nerve injury at the fibular head has been reported to be the most co...
Article
Full-text available
This case series reports 100 patients with lung cancer and their presenting neurologic symptoms and signs. 78% of patients were male and 22% were female. Mean age was 62± 1.04 years with a peak age between 65 and 75 years. Most patients presented with pulmonary problems (58%) and neurologic deficits as the presenting manifestations were found to be...
Article
Full-text available
Introduction: Homocysteimemia has been associated with increased risk for cerebralvasuclar disease and recurrent stroke. Homocysteinmia has primary atherogenic and prothrombotic properties. It can lead to both venous and arterial thrombosis by several mechanisms. We present a 45 years old female patient with hyperhomocysteinemia and past medical hi...

Citations

... To date, clinical trials have failed to demonstrate any significant effect of memantine on patients with MS whatever the parameter investigated: fatigue, cognitive performance, or spasticity [247][248][249][250][251] (Table 6). Worse still, adverse events have been reported in several studies. ...
... Most deaths are avoidable and occur in low-and middle-income countries (LMIC), due to a lack or a delay in identifying women at high-risk, and in their treatment [2][3][4][5]. HDP screening is an essential element of antenatal care (ANC) that allows the identification of women at high risk of developing HDP or HDP-related complications, and the implementation of preventive interventions for improving perinatal outcomes [6][7][8][9][10][11][12]. Screening for HDP at the first antenatal visit includes blood pressure measurement, urine testing for proteinuria, and identification of maternal risk factors [13][14][15][16][17]. ...
... Therapeutic advantages of MLC901 have already been depicted in patients suffering from stroke, Alzheimer's disease, mild cognitive impairment and vascular dementia [4][5][6]. Consistent with findings of clinical reports in efficacy and safety of MLC901, animal studies 258 have also established that MLC901 prevents the death of neuronal tissues, decreases cognitive dysfunction and also improves functional neurological outcome by restoring neuronal circuits in models of ischemia. MLC901has also shown neuroprotective and neurorestorative actions, which could potentially lead to the enhanced recovery of cognitive functions in animal models of TBI. ...
... Studies demonstrated, for example, the presence of high levels of anti-Candida antibodies and Candida antigens (proteins) in the blood and cerebrospinal fluid of MS patients [23][24][25][26]. In addition, the oral colonization of Candida spp. in MS patients was higher than in healthy individuals [27], and C. albicans isolated from MS patients presented a higher specific enzyme activity compared to C. albicans isolated from healthy individuals and had a positive correlation with the severity of MS [28]. Using the experimental autoimmune encephalomyelitis (EAE) model, which is extensively employed to study the immunopathogenesis of MS [29][30][31], our research group previously demonstrated that C. albicans spreads to the CNS and aggravates the development of EAE due to the increased production of encephalitogenic cytokines [32]. ...
... Cinnovex is an alternative medicine that has been produced in Iran in recent years and has shown satisfactory results. Studies have shown that the drug inhibits the progression of disability in patients with MS and controls its relapse and recurrence [16]. Due to the injectable use of all previous MS drugs, including Cinnovex and the difficulty of repeated injections and the short-term and long-term side effects resulting from the injections, patients tend to take oral Fingolimod. ...
... Increased quinolinic acid can lead to higher glutamate and upregulation of NMDA receptors. Glutamate is reported to be involved in migraine pathophysiology and at present treatments to block the NMDA receptor, such as memantine, are used in migraine prevention [66]. ...
... MS is a genetically complicated autoimmune disease in the CNS. Many published studies have illustrated that CD58 SNPs such as rs12044852 and rs2300747 are tightly related to MS risk in different populations, including European Caucasian, Iranian, Russians (168)(169)(170)(171)(172). A recent study found that carriers of the MS risk allele rs1414273 exhibited decreased CD58 mRNA levels but elevated miR-548ac levels through analyzing diverse datasets from global populations (173). ...
... There are some arguments that can explain the higher percentage of cases with nonreversible disease course (42 %) in our study. First, poor outcome of PRES seems related to a delayed diagnosis, thus supporting a previously report on delay in the elimination of the causes as an important predictor of poor outcome [11]. In addition, overrepresentation of critically ill patients (80 % of our patients required intensive care treatment) may be a potential indication of an irreversible course of PRES. ...
... Efficacy was measured using the ALSFRS-R, which ranged from 48 (normal) to 0 (fully impaired). Included studies used the following routes of administration: subcutaneous (13)(14)(15), combined intrathecal and intramuscular approach (18), intravenous followed by intralumbar injections (16), and intrathecal approach (17). Out of the six studies, three used Granulocyte colony-stimulating factor (G-CSF) (13)(14)(15), and the remaining used bone marrow mesenchymal stem cells (BM-MSC) (16)(17)(18). ...
... Chi-square analysis was used for comparison of categorical variables, and independent sample t-test and one-way ANOVA for quantitative variables (14,24). Logistic regression was used to analyse the effects of variables on bimodal outcome variables (16,26,30,31). ...