Mai H. ElNaggar's research while affiliated with Kafrelsheikh University and other places

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Publications (5)

Figure 3. Structures of cardenolides and steroids (2.1-2.12) reported...
Figure 4. Structures of coumarins and coumarinolignans (3.1-3.12)...
Figure 5. Structures of fatty acids and their derivatives (4.1-4.17)...
Figure 13. Miscellaneous compounds (12.1-12.2) reported in the genus...
+2 Current taxonomic status and synonyms of Salsola plants mentioned in...
The old world salsola as a source of valuable secondary metabolites endowed with diverse pharmacological activities: a review
Article
Full-text available
  • Dec 2022
Salsola is an important genus in the plant kingdom with diverse traditional, industrial, and environmental applications. Salsola species are widely distributed in temperate regions and represent about 45% of desert plants. They are a rich source of diverse phytochemical classes, such as alkaloids, cardenolides, triterpenoids, coumarins, flavonoids,...
Figure 2. Three-dimensional molecular model stick representation of 6-G...
Figure 3. Phase solubility diagram of 6-G in the presence of increasing...
Figure 8. The in vitro release profile of 6-G-loaded ENs, 6-G/HPβCD...
Figure 9. Scanning electron micrograph of the optimized 6-G-loaded...
+4 Figure 13. Cyclooxygenase inhibition activity, represented by IC50,...
Development of Cyclodextrin-Functionalized Transethoniosomes of 6-Gingerol: Statistical Optimization, In Vitro Characterization and Assessment of Cytotoxic and Anti-Inflammatory Effects
Article
Full-text available
  • May 2022
The poor solubility and stability of 6-gingerol (6-G) could hamper its clinical applications. The aim of the current study was to develop a novel ultra-deformable cyclodextrin-functionalized transethoniosomes (CD-TENs) as a promising delivery system for 6-G. Transethoniosomes (TENs) are flexible niosomes (NVs) due to their content of ethanol and ed...
Figure 3. 3D molecular model representation of the most active compound...
Figure 4. RMSDs of dimeric M pro (A) and aurasperone A inside the M pro...
Figure 5. M pro -aurasperone A contacts over two independent 150 ns MDS...
Aurasperone A Inhibits SARS CoV-2 In Vitro: An Integrated In Vitro and In Silico Study
Article
Full-text available
  • Feb 2022
Several natural products recovered from a marine-derived Aspergillus niger were tested for their inhibitory activity against SARS CoV-2 in vitro. Aurasperone A (3) was found to inhibit SARS CoV-2 efficiently (IC50 = 12.25 µM) with comparable activity with the positive control remdesivir (IC50 = 10.11 µM). Aurasperone A exerted minimal cytotoxicity...
Bio-guided Isolation of Natural Iron Chelators from Mangifera indica Leaves and their Comparative Study to Desferal ®
Article
  • Jan 2021
Through bio-guided isolation, two natural iron chelators were isolated from Mangifera indica L. leaves, identified as mangiferin (1) and iriflophenone-3-C-β-D-glucoside (2). Their iron-chelating activity was compared to that of Desferal ® using bipyridyl assay and EDTA as a standard. Mangiferin showed the highest activity with IC 50 value of 0.385...

Citations

... Separations 2023, 10, 72 ...
Reference: Anti-Inflammatory, Anti-Oxidant, GC-MS Profiling and Molecular Docking Analyses of Non-Polar Extracts from Five Salsola Species
... For poorly water-soluble drugs, adding solubilizers such as Tween-80, ethanol, and isopropanol in the release medium is recommended [57][58][59]. PBS containing 20% isopropanol at pH 7.4 was chosen as the receptor media in both the drug-release and drug-permeation studies to achieve the required sink conditions. This was because sink conditions are attained when the equilibrium solubility of drugs in the dissolving medium is at least three times the volume required for drug saturation [59]. ...
Reference: Preparation and Characterization of Patch Loaded with Clarithromycin Nanovesicles for Transdermal Drug Delivery
... A recent study published in 2022 found that the antimicrobial natural product aurasperone, as listed in Table 1, isolated from Aspergillus niger in the Red Sea tunicate Phallusia nigra, was highly effective against SARS-CoV-2 in vitro, with an IC 50 of 12.25 µM. The IC 50 result was comparable to the IC 50 of the positive control remdesivir, which was 10.11 µM [152]. The in silico analysis revealed that the molecule aurasperone A targets M pro in SARS-CoV-2 [152]. ...
Reference: Microbial Natural Products with Antiviral Activities, Including Anti-SARS-CoV-2: A Review