Mai H. ElNaggar's research while affiliated with Kafrelsheikh University and other places

Publications (5)

Article
Full-text available
Salsola is an important genus in the plant kingdom with diverse traditional, industrial, and environmental applications. Salsola species are widely distributed in temperate regions and represent about 45% of desert plants. They are a rich source of diverse phytochemical classes, such as alkaloids, cardenolides, triterpenoids, coumarins, flavonoids,...
Article
Full-text available
The poor solubility and stability of 6-gingerol (6-G) could hamper its clinical applications. The aim of the current study was to develop a novel ultra-deformable cyclodextrin-functionalized transethoniosomes (CD-TENs) as a promising delivery system for 6-G. Transethoniosomes (TENs) are flexible niosomes (NVs) due to their content of ethanol and ed...
Article
Full-text available
Several natural products recovered from a marine-derived Aspergillus niger were tested for their inhibitory activity against SARS CoV-2 in vitro. Aurasperone A (3) was found to inhibit SARS CoV-2 efficiently (IC50 = 12.25 µM) with comparable activity with the positive control remdesivir (IC50 = 10.11 µM). Aurasperone A exerted minimal cytotoxicity...
Article
Through bio-guided isolation, two natural iron chelators were isolated from Mangifera indica L. leaves, identified as mangiferin (1) and iriflophenone-3-C-β-D-glucoside (2). Their iron-chelating activity was compared to that of Desferal ® using bipyridyl assay and EDTA as a standard. Mangiferin showed the highest activity with IC 50 value of 0.385...

Citations

... For poorly water-soluble drugs, adding solubilizers such as Tween-80, ethanol, and isopropanol in the release medium is recommended [57][58][59]. PBS containing 20% isopropanol at pH 7.4 was chosen as the receptor media in both the drug-release and drug-permeation studies to achieve the required sink conditions. This was because sink conditions are attained when the equilibrium solubility of drugs in the dissolving medium is at least three times the volume required for drug saturation [59]. ...
... A recent study published in 2022 found that the antimicrobial natural product aurasperone, as listed in Table 1, isolated from Aspergillus niger in the Red Sea tunicate Phallusia nigra, was highly effective against SARS-CoV-2 in vitro, with an IC 50 of 12.25 µM. The IC 50 result was comparable to the IC 50 of the positive control remdesivir, which was 10.11 µM [152]. The in silico analysis revealed that the molecule aurasperone A targets M pro in SARS-CoV-2 [152]. ...