Mahmoud M. Ghorab's research while affiliated with Cairo University and other places

Publications (23)

Article
The biodegradable polymer poly-ε-(D, l-lactide-co-caprolactone) (PLCL) can be used to produce nanoparticles with tailored release pattern. In this study; the anti-epileptic drug, lamotrigine, was loaded in PLCL nanoparticles stabilized using various molecular weights and concentrations of polyvinyl alcohol (PVA). The nanoparticles were prepared by...
Article
A promising approach has been emerging to enhance dissolution of hydrophobicdrugsby encapsulation in mesoporous silica materials. Olanzapine is a practically insoluble antipsychotic drug which is subjected to excessive first pass effect and shows inadequate oral bioavailability. Therefore, mesoporous silica was used to improve bioavailability of ol...
Article
In this research, we examined the effect of rosuvastatin calcium-loaded nanoparticles on the hair growth–promoting activity on Albino rats. Nanoparticles were prepared using 2:1 weight ratio of drug to methyl-β-cyclodextrin with 10, 20, and 30% stabilizers (phospholipid, polyvinyl pyrrolidone K30, and Compritol 888 ATO) using nanospray dryer. Subse...
Article
Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for sustained pulmonary delivery of sildenafil citrate. Spray dried hydrogel microparticles containing biodegradable sodi...
Poster
Full-text available
Skin regeneration. https://www.sciencedirect.com/science/article/pii/S0928098718304937
Article
In this study we explored the role of rosuvastatin calcium in skin regeneration as statins play important role in the field of tissue engineering. Chitosan hydrochloride was crosslinked with different weight ratios of collagen, β-glycerolphosphate and carboxymethyl cellulose to produce scaffolds by lyophilization technique. Subsequently, the fabric...
Article
The aim of the work was to improve carvedilol bioavailability through preparation of nanoparticles to be formulated as a buccoadhesive gel. Physicochemical compatibility of drug was studied. The ionic gelation technique was used for nanoparticles preparation based on 31 × 41 factorial design using Eudragit® RS100 as a complexing agent. Particle siz...
Article
Management of epilepsy requires brain delivery therapy, therefore, this study was aimed to prepare lamotrigine loaded poly-ɛ-(d,l-lactide-co-caprolactone) (PLCL) nanoparticles using spontaneous emulsification solvent diffusion method. Nanoparticles for brain delivery required to have a particle size <200 nm, polydispesity index <0.2 and a sustained...
Article
Full-text available
Nano-spray dryer is advanced instrument to produce a stable and spherical nanoparticles with high yield. In this study, econazole nitrate nanoparticles were formulated by nano-spray dryer using 1:1, 1:2 and 1:3 weight ratios of drug to hydroxypropyl-beta-cyclodextrin and stabilizer. The prepared samples were sprayed through nozzle size of 7.0 μm us...
Article
Tadalafil suffers from poor aqueous solubility that could lead to fluctuating blood levels and unreproducible effect. Thus, this work aimed at improving tadalafil dissolution utilizing the approach of surfactant-enriched tablets. The feasibility of minimizing various surfactants quantities was investigated by establishing the ratio of the surfactan...
Article
Full-text available
The purpose of this study is to screen various preformulation studies in early stages of dosage form development, in order to reach a preliminary optimized group of lamotrigine (LTG) loaded polymeric nanoparticles, with certain characteristics that would permit brain targeting through parenteral administration. Various preformulation studies were c...
Article
Full-text available
Risperidone is effective in the treatment of positive as well as negative symptoms of schizophrenia. But, there is a strong correlation between plasma levels of risperidone and its adverse effects. Objective: This study aimed to develop risperidone in floating microparticles to overcome its extrapyramidal side effects. Methods: Floating micropartic...
Article
The effect of using methyl-β-cyclodextrin and hydroxylpropyl-β-cyclodextrin as carriers for econazole nitrate nanoparticles prepared by nano-spray dryer was explored in this work. Stabilizers were also used as polyethylene oxide, polyvinylpyrrolidone k30, poloxamer 407, Tween 80 and Cremophor EL. The nano-spray dried formulations revealed almost sp...
Article
Full-text available
Fluticasone propionate is a synthetic corticosteroid drug distinguished by its potent anti-inflammatory action with low systemic side effects in comparison to other corticosteroids making it a potential drug for local buccal delivery. The aim of the present study was to design mucoadhesive buccal film containing fluticasone that is aesthetically ac...
Article
Full-text available
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Article
Full-text available
This work aimed to formulate sildenafil citrate rapidly disintegrating tablets with enhanced stability utilizing the approach of incorporating antioxidant simultaneously with pH modifier for adjusting the tablet microenvironmental pH. Studies for effect of pH on the drug saturated solutions stability revealed that the drug exhibited maximum stabili...
Article
The aim of this work was to investigate the inclusion complexation between tadalafil, a practically insoluble selective phosphodiesterase-5 inhibitor (PDE5), and two chemically modified beta-cyclodextrins: hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and heptakis-[2,6-di-O-methyl]-beta-cyclodextrin (DM-beta-CD), in comparison with the natural beta-...
Article
Abstract Complexation between danazol, a steroid used for endometriosis, and both hydroxypropyl- β-cyclodextrin (HPCD) and sulfobutyl ether-β-cyclodextrin (SBE) was studied in solution and solid state. Complexation was evaluated in solution using solubility studies and proton magnetic resonance (1H NMR) spectroscopy, and in the solid state using x-...
Article
Bioavailability of danazol-hydroxypropyl-β-cyclodextrin complex was investigated in rats and dogs using different routes of administration. The complex was administered buccally in an aqueous solution form to rats in which the esophagus had been ligated to prevent swallowing of the complex, while oral administration was by gastric gavage. In dogs,...
Article
Danazol, a steroid with very low aqueous solubility and poor bioavailability, and its coprecipitates were characterized for solubility, dissolution rate and bioavailability. Solubility diagrams of danazol in aqueous hydrox-ypropyl β-cyclodextrin (HPCD) solutions and isopropanol/water solutions were constructed with concentration of HPCD solutions r...

Citations

... The first is that, both were considered PEGylated lipid and solubility enhancers for the hydrophobic drug, which augments the amount of drug incorporated into the nanostructured (Houacine et al., 2020) since LORA exhibited as a model of 'very lipophilic' drug (Sarheed et al., 2020). However, the higher EE% of LORA-NLCs fabricated with Labrasol ® than Labrafil ® , might be due to various crystal defects in the solid lipid as well as imperfections in the highly ordered crystal matrix caused by Labrasol ® , this result complies with the previously reported (Ammar et al., 2021), regarding the effect of incorporation of Labrasol ® into the solid lipid matrix rendering the NLCs to become more imperfect, thus yielding, sufficient space in solid lipid matrix for a large quantity of drug to lodge effectively. Furthermore, the EE% results declared that the X3: Type of SAA had a significant (p < .0001) ...
... The low PDI values indicate the narrow particle size distribution and formation of more stable nanoparticles [73]. Moreover, high ZP values were favored due to electric repulsion and, thus, less particles aggregation [74]. The FTIR spectrum of the non-medicated formula SCM8-1 showed a characteristic peak at 1034.24 cm −1 which is related to the chemical bonding between silica and nitrogen (Si-N single bonding). ...
... Spray drying is gaining popularity as a gentle, one-step, continuous, and scalable method for drying liquids into dry powder to be used in different routes of administration (Mahmoud et al., 2018;Maged et al., 2020). It enables the drying of particles with controlled size and shape in the field of particle engineering (Schmid et al., 2011;Arpagaus, 2012). ...
... When the concentration of L-leucine in formulations (F5) was increased, the percentage yield was also improved due to the hydrophobic coating of L-leucine on the surface of spray-dried particles that were deposited as individual particles. The results of our study were in coherence with the previous study, whereby L-leucine incorporated formulations achieved a higher yield of spray-dried microparticles [36]. The higher yield of spray-dried microparticles as a function of alginate concentration could be contributed to a corresponding increase in feed solution viscosity, which has been shown to affect particle size (Table 2) [55]. ...
... Statins are a class of drugs that are well-known for their lipid-lowering effect; accordingly, they are generally given for the treatment of cardiovascular diseases [5]. Recently, research has shown their ability to manage conditions other than heart problems, such as neurological conditions [6], cancer [7] and inflammation [8], in addition to many dermatological conditions, such as urticaria [9], acne [10], psoriasis [11] and wound healing [12]. Rosuvastatin (ROS) is one of the statins that lowers low-density lipoprotein and raises high-density lipoprotein by inhibiting 3-hydroxy3-methyl glutaryl co-enzyme A (HMG-COA) reductase [13]. ...
... Release profiles of tested samples were represented by plotting the% cumulative amounts of DRN released against time (h). Similarity factor (ƒ2) was calculated to compare the release profile of the optimal niosomal dispersion and niosomal in situ gel to that of the drug-free suspension according to the following equation [36]: ...
... Carbamazepineloaded poloxamer 188-coated PLGA NPs exerted a 30-fold increase in anti-convulsive effect in the rat model of isoniazid-induced epilepsy [237]. Loading of lamotrigine to poly-ɛ-D,L-lactide-co-caprolactone significantly improves the bioavailability of the drug [238]. Furthermore, the application of lamotrigineloaded PLGA delayed seizure onset and improved drug release and bioavailability in experimental animal models [239]. ...
... Figure 10C) was also noticed with an increase of MAA contents when other constituents' concentrations remained constant. Improvement in drug release with increased concentration of HPβCD and methacrylic acid during preparation of the pH-sensitive hydrogel has already been reported in literature [29,30]. ...
... TDL is classified as a class II medication by the Biopharmaceutics Classification System (BCS), having poor solubility and high permeability characteristics [10]. Despite its good permeability, TDL bioavailability is limited by poor solubility and dissolution rate, resulting in erratic absorption, fluctuation of drug blood levels, and unreproducible effect clinical outcomes [11]. ...
... On the other hand, an endothermic broad peak at 162°C is shown for the lyophilized risperidone. Broad endothermic peak is including lower in melting points, broadening, shifting, and reducing in intensities supported the suggestion of a reduction in the crystalline state of risperidone optimized formula with a significant increment in the amorphous state that formed in lyophilization (30) . ...