Mahmoud Alagawany’s research while affiliated with Zagazig University and other places

Follistatin (FST) is a cysteine-rich monomeric protein capable of binding and neutralizing the action of several members of the transforming growth factor-beta (TGFβ) family, such as myostatin and activin, by binding to their receptors. The aim of the present study was to characterize the FST gene and its receptors in quail. Genomic sequences of the FST gene and its receptors in quail were obtained from the National Center for Biotechnology Information (NCBI) database. Analyses of evolutionary relationship, conserved domain, gene structure, and motif pattern of the FST gene family showed the evolutionary conserved nature in quail and other related avian species. Most of the FST proteins are acidic, thermostable, unstable, and hydrophilic in nature, except for FSTL2 and FSTL3, which were basic in nature. A comparative amino acid analysis showed a higher amino acid variation in quail FST genes, as a total of 102 single amino acid changes were identified in all quail FST genes. Mutation analysis showed that 15 mutations had an overall deleterious effect on the structure and functions of the proteins in quail. Molecular docking and Dynamic Simulation (MD) simulation were performed to study dynamics of more promising compounds such as isovitexin, apigetrin, and fleminchaloneto, revealing stability of ligand-protein complex. The values of Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), and results of isovitexin indicated that ligand-protein complex was more compacted than enzymes that are native. This study provides insights into the molecular structure of FST genes in avian species, while exploring the potential of single nucleotide polymorphisms (SNPs) in selective breeding of quail for better performance. Keywords: Follistatin; activin; quail; myostatin; transforming growth factor beta family; molecular docking simulation

Due to their useful nutrient availability, soybean meal and yellow maize are frequently utilized as staple components in chicken feed. However, there is a huge demand for these two feedstuffs from animals (e.g., yellow corn and soybean meal). Humanity’s numbers are expected to rise to 9.1 billion by 2050. The demand for poultry goods including meat and eggs is rising worldwide. As a result, the demand for poultry feed will rise globally. The supply of wholesome feed for chickens is getting more and scarcer today. Food security will be at risk, particularly in developing nations. Efforts are being made to replace portions of the most traditional feedstuffs, i.e., soybean meal and yellow corn, with alternate ones. The present review explores the nontraditional alternate feed ingredients which could be included in poultry diets. Moreover, the nutritional value of these alternatives and their bioavailability are explored in this review, alongside means that applied to enhance the nutritional value of these alternatives.

Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production explores the use of plant-derived compounds as innovative feed additives to enhance animal health and productivity. With growing concerns over antibiotic resistance and the ban on antibiotics as growth promoters, this book highlights phytogenic feed additives (PFAs) such as essential oils, flavonoids, and saponins as sustainable and effective alternatives. The book covers various PFAs, including thyme, turmeric, milk thistle, rosemary, bee pollen, and propolis, and their roles in improving growth rates, gut health, immunity, and product quality while mitigating environmental and health risks. The book also provides practical insights for the livestock industry and food sectors to enhance animal well-being and food safety. Key Features: - Reviews the latest research on natural PFAs. - Highlights their antioxidant, antimicrobial, and growth-promoting properties. - Provides practical applications for sustainable livestock production.

Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production explores the use of plant-derived compounds as innovative feed additives to enhance animal health and productivity. With growing concerns over antibiotic resistance and the ban on antibiotics as growth promoters, this book highlights phytogenic feed additives (PFAs) such as essential oils, flavonoids, and saponins as sustainable and effective alternatives. The book covers various PFAs, including thyme, turmeric, milk thistle, rosemary, bee pollen, and propolis, and their roles in improving growth rates, gut health, immunity, and product quality while mitigating environmental and health risks. The book also provides practical insights for the livestock industry and food sectors to enhance animal well-being and food safety. Key Features: - Reviews the latest research on natural PFAs. - Highlights their antioxidant, antimicrobial, and growth-promoting properties. - Provides practical applications for sustainable livestock production.

Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production explores the use of plant-derived compounds as innovative feed additives to enhance animal health and productivity. With growing concerns over antibiotic resistance and the ban on antibiotics as growth promoters, this book highlights phytogenic feed additives (PFAs) such as essential oils, flavonoids, and saponins as sustainable and effective alternatives. The book covers various PFAs, including thyme, turmeric, milk thistle, rosemary, bee pollen, and propolis, and their roles in improving growth rates, gut health, immunity, and product quality while mitigating environmental and health risks. The book also provides practical insights for the livestock industry and food sectors to enhance animal well-being and food safety. Key Features: - Reviews the latest research on natural PFAs. - Highlights their antioxidant, antimicrobial, and growth-promoting properties. - Provides practical applications for sustainable livestock production.

Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production explores the use of plant-derived compounds as innovative feed additives to enhance animal health and productivity. With growing concerns over antibiotic resistance and the ban on antibiotics as growth promoters, this book highlights phytogenic feed additives (PFAs) such as essential oils, flavonoids, and saponins as sustainable and effective alternatives. The book covers various PFAs, including thyme, turmeric, milk thistle, rosemary, bee pollen, and propolis, and their roles in improving growth rates, gut health, immunity, and product quality while mitigating environmental and health risks. The book also provides practical insights for the livestock industry and food sectors to enhance animal well-being and food safety. Key Features: - Reviews the latest research on natural PFAs. - Highlights their antioxidant, antimicrobial, and growth-promoting properties. - Provides practical applications for sustainable livestock production.

Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production explores the use of plant-derived compounds as innovative feed additives to enhance animal health and productivity. With growing concerns over antibiotic resistance and the ban on antibiotics as growth promoters, this book highlights phytogenic feed additives (PFAs) such as essential oils, flavonoids, and saponins as sustainable and effective alternatives. The book covers various PFAs, including thyme, turmeric, milk thistle, rosemary, bee pollen, and propolis, and their roles in improving growth rates, gut health, immunity, and product quality while mitigating environmental and health risks. The book also provides practical insights for the livestock industry and food sectors to enhance animal well-being and food safety. Key Features: - Reviews the latest research on natural PFAs. - Highlights their antioxidant, antimicrobial, and growth-promoting properties. - Provides practical applications for sustainable livestock production.

Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production explores the use of plant-derived compounds as innovative feed additives to enhance animal health and productivity. With growing concerns over antibiotic resistance and the ban on antibiotics as growth promoters, this book highlights phytogenic feed additives (PFAs) such as essential oils, flavonoids, and saponins as sustainable and effective alternatives. The book covers various PFAs, including thyme, turmeric, milk thistle, rosemary, bee pollen, and propolis, and their roles in improving growth rates, gut health, immunity, and product quality while mitigating environmental and health risks. The book also provides practical insights for the livestock industry and food sectors to enhance animal well-being and food safety. Key Features: - Reviews the latest research on natural PFAs. - Highlights their antioxidant, antimicrobial, and growth-promoting properties. - Provides practical applications for sustainable livestock production.

Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production explores the use of plant-derived compounds as innovative feed additives to enhance animal health and productivity. With growing concerns over antibiotic resistance and the ban on antibiotics as growth promoters, this book highlights phytogenic feed additives (PFAs) such as essential oils, flavonoids, and saponins as sustainable and effective alternatives. The book covers various PFAs, including thyme, turmeric, milk thistle, rosemary, bee pollen, and propolis, and their roles in improving growth rates, gut health, immunity, and product quality while mitigating environmental and health risks. The book also provides practical insights for the livestock industry and food sectors to enhance animal well-being and food safety. Key Features: - Reviews the latest research on natural PFAs. - Highlights their antioxidant, antimicrobial, and growth-promoting properties. - Provides practical applications for sustainable livestock production.

Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production explores the use of plant-derived compounds as innovative feed additives to enhance animal health and productivity. With growing concerns over antibiotic resistance and the ban on antibiotics as growth promoters, this book highlights phytogenic feed additives (PFAs) such as essential oils, flavonoids, and saponins as sustainable and effective alternatives. The book covers various PFAs, including thyme, turmeric, milk thistle, rosemary, bee pollen, and propolis, and their roles in improving growth rates, gut health, immunity, and product quality while mitigating environmental and health risks. The book also provides practical insights for the livestock industry and food sectors to enhance animal well-being and food safety. Key Features: - Reviews the latest research on natural PFAs. - Highlights their antioxidant, antimicrobial, and growth-promoting properties. - Provides practical applications for sustainable livestock production.