Maarten Jaspers's scientific contributions
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Publications (5)
Developing a robust roller compaction process can be challenging, due to the diversity in process parameters and material properties of the components in a formulation. A major challenge in dry granulation is the reduction of tablet strength as a result of re-compaction of the materials. The aim of this study is to investigate the impact of excipie...
Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI) formulations. Numerous inhalation therapies have been developed using lactose as a carrier material. Several theories have described the role of carriers in DPI formulations. Although these theories are valuable, each DPI formulation is unique and are not descr...
Dry granulation via roller compaction is increasingly being used as granulation method for the production of oral solid dosage forms. Advantages of roller compaction include a simplified process compared to wet granulation and the inherently continuous nature of the process. A common problem of dry granulation, however, is the loss of compactibilit...
The material properties of excipients and active pharmaceutical ingredients (API's) are important parameters that affect blend uniformity of pharmaceutical powder formulations. With the current shift from batch to continuous manufacturing in the pharmaceutical industry, blending of excipients and API is converted to a continuous process. The relati...
Stimulated by Pharma 4.0, the pharmaceutical industry is changing from batch-wise to continuous manufacturing. Therefore, individual processing steps such as blending of the active pharmaceutical ingredient (API) with excipients have to be re-designed to continuous operations. In this study, batch and continuous powder blending are directly compare...
Citations
... In order to explain how the addition of superdisintegrant prior to granulation reduces the loss of compactibility of anhydrous lactose, the proposed mechanisms for the loss of compactibility need to be considered. Granule size enlargement has been previously shown not to affect the compactibility of brittle materials such as lactose [11,29]. Also for the current study, size enlargement cannot explain the observed loss in compactibility since the size of the granules does not increase upon increasing the specific compaction force from 7 to 16 kN/cm (Fig. S1). ...
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... In this continuous blending process, the starting materials are continuously fed to the blender at a fixed rate, and the blended material exits the blender at the same mass rate. A continuous blending process has been shown to be advantageous in the blending of a variety of powdered materials, including combinations of drugs and excipient particles [172][173][174]. However, the use of continuous blending processes is not yet common in the blending of adhesive mixtures for DPIs. ...
