September 1972
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5 Reads
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22 Citations
Thrombosis et Diathesis Haemorrhagica
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September 1972
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5 Reads
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22 Citations
Thrombosis et Diathesis Haemorrhagica
January 1972
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12 Reads
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9 Citations
Pathophysiology of Haemostasis and Thrombosis
The mechanism of blood loss-induced thrombopoiesis was studied by measuring thrombocyte and megathrombocyte (young platelet) kinetics in guinea pigs made thrombocytotic by acute or chronic blood loss. The effect of an Fe-deficient diet was also examined. Acute and chronic blood loss raised the platelet count 1.2- and 1.4-fold, respectively Simultaneous replacement of Fe loss raised the platelet count 2.1- and 2.5-fold in acute and chronic blood loss, respectively. Paradoxically, an Fe-deficient diet also raised the platelet count 1.4-fold. Megathrombocyte number increased 1.4-fold more than the increase in platelet count for both acute and chronic blood loss. Simultaneous replacement of Fe produced an increase in megathrombocyte number which was 1.8- and 1.6-fold greater than the increase in platelet count for acute and chronic blood loss, respectively. Animals on an Fe-deficient diet did not raise their megathrombocyte number above their rise in platelet count. Thus, Fe is required for megathrombocyte production. A two-compartment system is postulated for the effect of Fe on thrombocytosis. (1) Fe inhibits the rise in platelet count above steady-state levels. (2) Fe is also required for maximum platelet production above steady-state levels via the production of megathrombocytes.The increment in megathrombocyte production following acute or chronic blood loss could account for one-quarter of thrombocyte production if one megathrombocyte gives rise to one thrombocyte. Alternatively, one megathrombocyte could give rise to four thrombocytes in the peripheral circulation. It is suggested that this latter mechanism may be important physiologically.
... The mechanism of TCP in patients with IDA is not well understood. Garg et al. documented that iron-deficient animals severely reduced platelet count (Garg et al., 1972). It was demonstrated that iron has an important role in platelet protein synthesis (Freedman & Karpatkin, 1973). ...
January 1972
Pathophysiology of Haemostasis and Thrombosis